Magnesium isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function
Guang-Hua Tang, Hua-Yu Yang, Jin-Chun Zhang, Jin-Jun Ren, Xin-Ting Sang, Xin Lu, Shou-Xian Zhong, Yi-Lei Mao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing 100730, China
Author contributions: Mao YL and Yang HY designed the research; Tang GH, Yang HY, Ren JJ and Zhang JC performed the research; Sang XT, Zhong SX and Lu X contributed new reagents or analytic tools; Tang GH analyzed the data and wrote the paper.
Supported by a grant from the State Science and Technology Ministry, No. 2012BAI06B01.
Institutional review board statement: The study protocol was approved by the Ethics Committee of the Peking Union Medical College Hospital.
Institutional animal care and use committee statement: All animal experiments were reviewed and approved by the Ethics Committee of the Peking Union Medical College Hospital.
Conflict-of-interest statement: The authors have none to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi-Lei Mao, MD, PhD, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and PUMC, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. firstname.lastname@example.org
Telephone: +86-10-69156042 Fax: +86-10-69156043
Received: May 4, 2015
Peer-review started: May 5, 2015
First decision: June 3, 2015
Revised: June 18, 2015
Accepted: September 14, 2015
Article in press: September 15, 2015
Published online: November 21, 2015