Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis
Samira M Sadowski, Axel Andres, Philippe Morel, Leo Bühler, Department of Visceral and Transplantation Surgery, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
Eduardo Schiffer, Department of Anesthesiology, University Hospital Geneva, 1211 Geneva 14, Switzerland
Jean-Louis Frossard, Department of Gastroenterology, University Hospital Geneva, 1211 Geneva 14, Switzerland
Alexandra Platon, Pierre-Alexandre Poletti, Department of Radiology, University Hospital Geneva, 1211 Geneva 14, Switzerland
Author contributions: Bühler L, Morel P, Poletti PA, Schiffer E and Frossard JL designed the research; Sadowski SM, Andres A, Schiffer E, Platon A and Poletti PA performed the research; Sadowski SM, Andres A, Schiffer E, Platon A, Poletti PA and Frossard JL analyzed the data; Sadowski SM, Bühler L, Platon A and Poletti PA wrote the paper.
Supported by a research grant of the University Hospitals of Geneva (to Bühler L).
Institutional review board statement: The Ethics Board of Geneva’s University Hospital approved the study in 2004 (HUG 02-0555).
Clinical trial registration statement: This study is registered at http://www.clinicaltrials.gov. The registration identification number is NCT01607996.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: This study was funded by a research grant from the University Hospitals of Geneva to Bühler Leo. JL Frossard received payment from the University Hospitals of Geneva for lectures. The other authors have nothing to disclose.
Data sharing statement: Consent was not obtained, but the presented data are anonymized and the risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Leo Bühler, Professor, Department of Visceral and Transplantation Surgery, University Hospitals of Geneva, Rue Gabrielle Perret-Gentil 4, 1211 Geneva 14. Switzerland. firstname.lastname@example.org
Telephone: +41-22-3727698 Fax: +41-22-3727689
Received: May 2, 2015
Peer-review started: May 8, 2015
First decision: June 2, 2015
Revised: June 19, 2015
Accepted: September 14, 2015
Article in press: September 15, 2015
Published online: November 21, 2015