Systematic Reviews
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2015; 21(43): 12482-12497
Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12482
Cooperative laparoscopic endoscopic and hybrid laparoscopic surgery for upper gastrointestinal tumors: Current status
Dimitrios Ntourakis, Georgios Mavrogenis
Dimitrios Ntourakis, Third Department of Surgery, University of Athens Faculty of Medicine, Attikon University Hospital, Rimini 1, 12463 Chaidari, Athens, Greece
Georgios Mavrogenis, Service de Gastroentérologie, Site Notre Dame, Grand Hôpital de Charleroi, 3 Grande Rue, 6000 Charleroi, Belgium
Georgios Mavrogenis, Gastroenterology and Endoscopy Center of Mytilene, Kavetsou 10, 81100 Mytilene, Greece
Author contributions: Ntourakis D designed the study and performed the research; Mavrogenis G analyzed data; Ntourakis D drew the figures; Ntourakis D and Mavrogenis G wrote the paper; all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: The paper dataset and literature search results are available from the corresponding author at
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dimitrios Ntourakis, MD, PhD, Third Department of Surgery, University of Athens Faculty of Medicine, Attikon University Hospital, Rimini 1, T.K. 12463 Chaidari, Athens, Greece.
Telephone: +30-210-9822952 Fax: +30-210-5326411
Received: April 29, 2015
Peer-review started: May 12, 2015
First decision: August 25, 2015
Revised: September 15, 2015
Accepted: October 17, 2015
Article in press: October 20, 2015
Published online: November 21, 2015
Processing time: 203 Days and 9 Hours
Core Tip

Core tip: Cooperative laparoscopic and endoscopic surgery for the resection of upper gastrointestinal tumors combines the advantages of intraluminal and extraluminal approach: precise lesion localization, safe excision and reconstruction. It has been used for the resection of benign submucosal tumors and Gastrointestinal stromal tumors. Novel techniques like inverted laparoscopic endoscopic cooperative surgery, laparoscopic assisted endoscopic full thickness resection, clean non exposure technique and non-exposed endoscopic wall-inversion surgery have emerged for the minimally invasive treatment of early gastric cancer. Their oncologic principles are sound and the first results encouraging. Soon, the close collaboration of laparoscopic and endoscopic teams will be “conditio sine qua non” for the institutions that seek excellence in the treatment of upper gastrointestinal neoplasias.