Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12211
Peer-review started: July 4, 2015
First decision: August 26, 2015
Revised: September 20, 2015
Accepted: October 17, 2015
Article in press: October 20, 2015
Published online: November 21, 2015
Core tip: The outcome of gallbladder carcinoma is poor. In patients with early-stage disease, a 5-year survival rate of 75% is possible. Stage-adjusted therapy is key for improving survival. Despite the theoretical risk factors of gallbladder malignancies, only a third of gallbladder carcinomas are recognized preoperatively, and radical re-resection in cases of incidental discoveries of incidental or occult gallbladder carcinomas is often crucial to complete a so called radical cholecystectomy. Unfortunately, there are diverse interpretations and practices regarding stage-adjusted therapy for gallbladder carcinoma patients. The current data suggest that more radical therapy is warranted.