- Artificial Intelligence in Cancer
- Artificial Intelligence in Gastroenterology
- Artificial Intelligence in Gastrointestinal Endoscopy
- Artificial Intelligence in Medical Imaging
- World Journal of Anesthesiology
- World Journal of Biological Chemistry
- World Journal of Cardiology
- World Journal of Clinical Cases
- World Journal of Clinical Infectious Diseases
- World Journal of Clinical Oncology
- World Journal of Clinical Pediatrics
- World Journal of Clinical Urology
- World Journal of Critical Care Medicine
- World Journal of Dermatology
- World Journal of Diabetes
- World Journal of Experimental Medicine
- World Journal of Gastroenterology
- World Journal of Gastrointestinal Endoscopy
- World Journal of Gastrointestinal Oncology
- World Journal of Gastrointestinal Pathophysiology
- World Journal of Gastrointestinal Pharmacology and Therapeutics
- World Journal of Gastrointestinal Surgery
- World Journal of Hematology
- World Journal of Hepatology
- World Journal of Hypertension
- World Journal of Immunology
- World Journal of Medical Genetics
- World Journal of Meta-Analysis
- World Journal of Methodology
- World Journal of Nephrology
- World Journal of Neurology
- World Journal of Obstetrics and Gynecology
- World Journal of Ophthalmology
- World Journal of Orthopedics
- World Journal of Otorhinolaryngology
- World Journal of Pharmacology
- World Journal of Psychiatry
- World Journal of Radiology
- World Journal of Respirology
- World Journal of Rheumatology
- World Journal of Stem Cells
- World Journal of Stomatology
- World Journal of Surgical Procedures
- World Journal of Translational Medicine
- World Journal of Transplantation
- World Journal of Virology
- 世界华人消化杂志
Editorial
Motohiko Kato
World J Gastroenterol
21(44):12513-12518.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12513
Abstract (1082)
|
Core Tip (915)
|
Full Article (HTML) (3543)
|
Figures (1-2) (148)
|
Tables (1-3) (312)
|
Full Article (PDF)-1314K (602)
|
Peer-Review Report-79K (230)
|
Answering Reviewers-56K (182)
|
Received: 04/28/2015
|
Revised: 07/23/2015
|
Accepted: 09/30/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (13)
|
Total Visits (12701)
|
Similar Articles (279)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Frontier
Emilio G Quetglas, Zlatan Mujagic, Simone Wigge, Daniel Keszthelyi, Sebastian Wachten, Ad Masclee, Walter Reinisch
World J Gastroenterol
21(44):12519-12543.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12519
Abstract (1126)
|
Core Tip (890)
|
Full Article (HTML) (7960)
|
Figures (1-8) (278)
|
Full Article (PDF)-1658K (831)
|
Peer-Review Report-89K (188)
|
Answering Reviewers-102K (207)
|
Received: 02/06/2015
|
Accepted: 09/14/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (23)
|
Total Visits (17826)
|
Similar Articles (79)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Review
Indu Srinivasan, Shou-Jiang Tang, Andreas S Vilmann, John Menachery, Peter Vilmann
World J Gastroenterol
21(44):12544-12557.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12544
Abstract (1066)
|
Core Tip (915)
|
Full Article (HTML) (7348)
|
Figures (1-5) (532)
|
Tables (1-1) (291)
|
Full Article (PDF)-1556K (547)
|
Peer-Review Report-146K (149)
|
Answering Reviewers-67K (270)
|
Received: 05/08/2015
|
Revised: 09/28/2015
|
Accepted: 10/13/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (12)
|
Total Visits (16352)
|
Similar Articles (170)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Sobia Manzoor, Muhammad Saalim, Muhammad Imran, Saleha Resham, Javed Ashraf
World J Gastroenterol
21(44):12558-12575.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12558
Abstract (1468)
|
Core Tip (1312)
|
Full Article (HTML) (12998)
|
Figures (1-1) (284)
|
Tables (1-5) (185)
|
Full Article (PDF)-1451K (1447)
|
Peer-Review Report-71K (361)
|
Answering Reviewers-66K (586)
|
Received: 04/21/2015
|
Revised: 07/24/2015
|
Accepted: 10/20/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (35)
|
Total Visits (36897)
|
Similar Articles (0)
|
Timeline of Article Publication (1)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Basic Study
Gozde Dervis Hakim, Mujde Soyturk, Mehtat Unlu, Pinar Ataca, Meral Karaman, Ozgul Sagol, Elif Borekci, Osman Yilmaz
World J Gastroenterol
21(44):12576-12585.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12576
Abstract (970)
|
Core Tip (886)
|
Full Article (HTML) (3302)
|
Figures (1-6) (186)
|
Tables (1-1) (164)
|
Full Article (PDF)-1086K (422)
|
Peer-Review Report-104K (178)
|
Answering Reviewers-115K (207)
|
Received: 03/26/2015
|
Revised: 06/05/2015
|
Accepted: 09/14/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (2)
|
Total Visits (11926)
|
Similar Articles (26)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Yuan-Ying Shen, Wei Hou, Zhan-Qiu Yang, Wen Xiao
World J Gastroenterol
21(44):12586-12592.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12586
Abstract (858)
|
Core Tip (872)
|
Full Article (HTML) (2727)
|
Tables (1-4) (259)
|
Full Article (PDF)-974K (373)
|
Peer-Review Report-124K (229)
|
Answering Reviewers-93K (159)
|
Received: 02/24/2015
|
Revised: 04/12/2015
|
Accepted: 08/25/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (9)
|
Total Visits (10182)
|
Similar Articles (372)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Potential effect of chronic Helicobacter pylori infection on glucose metabolism of Mongolian gerbils 
Zhen Yang, Wei Li, Cong He, Chuan Xie, Yin Zhu, Nong-Hua Lu
World J Gastroenterol
21(44):12593-12604.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12593
Abstract (925)
|
Core Tip (849)
|
Full Article (HTML) (3278)
|
Figures (1-6) (167)
|
Full Article (PDF)-1493K (416)
|
Peer-Review Report-103K (197)
|
Answering Reviewers-154K (201)
|
Received: 04/16/2015
|
Revised: 06/19/2015
|
Accepted: 09/14/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (6)
|
Total Visits (10586)
|
Similar Articles (339)
|
Timeline of Article Publication (1)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Case Control Study
Studied microRNA gene expression in human hepatocellular carcinoma by microRNA microarray techniques
Jian-Xiang Niu, Xing-Kai Meng, Jian-Jun Ren
World J Gastroenterol
21(44):12605-12611.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12605
Abstract (925)
|
Core Tip (807)
|
Full Article (HTML) (3686)
|
Figures (1-4) (194)
|
Full Article (PDF)-1217K (483)
|
Peer-Review Report-94K (173)
|
Answering Reviewers-567K (240)
|
Received: 05/24/2015
|
Revised: 07/26/2015
|
Accepted: 10/13/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (8)
|
Total Visits (10562)
|
Similar Articles (1630)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Retrospective Cohort Study
Ji Yeon Park, Yong Jin Kim
World J Gastroenterol
21(44):12612-12619.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12612
Abstract (950)
|
Core Tip (954)
|
Full Article (HTML) (4214)
|
Figures (1-2) (164)
|
Tables (1-4) (155)
|
Full Article (PDF)-1131K (600)
|
Peer-Review Report-88K (195)
|
Answering Reviewers-140K (176)
|
Received: 03/16/2015
|
Revised: 05/26/2015
|
Accepted: 08/31/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (19)
|
Total Visits (10983)
|
Similar Articles (20)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
I Che Feng, Szu Jen Wang, Ming Jen Sheu, Lok-Beng Koay, Ching Yih Lin, Chung Han Ho, Chi Shu Sun, Hsing Tao Kuo
World J Gastroenterol
21(44):12620-12627.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12620
Abstract (1069)
|
Core Tip (903)
|
Full Article (HTML) (2767)
|
Figures (1-2) (149)
|
Tables (1-3) (161)
|
Full Article (PDF)-1034K (344)
|
Peer-Review Report-82K (181)
|
Answering Reviewers-89K (339)
|
Received: 04/05/2015
|
Revised: 07/07/2015
|
Accepted: 09/02/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (1)
|
Total Visits (9150)
|
Similar Articles (1)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Retrospective Study
Hiroaki Shimizu, Atsushi Kato, Tsukasa Takayashiki, Satoshi Kuboki, Masayuki Ohtsuka, Hideyuki Yoshitomi, Katsunori Furukawa, Masaru Miyazaki
World J Gastroenterol
21(44):12628-12634.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12628
Abstract (1136)
|
Core Tip (988)
|
Full Article (HTML) (5251)
|
Figures (1-3) (212)
|
Tables (1-2) (147)
|
Full Article (PDF)-1683K (562)
|
Peer-Review Report-123K (191)
|
Answering Reviewers-163K (209)
|
Received: 04/10/2015
|
Revised: 07/31/2015
|
Accepted: 09/30/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (16)
|
Total Visits (12134)
|
Similar Articles (0)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Haruhisa Suzuki, Ichiro Oda, Masau Sekiguchi, Seiichiro Abe, Satoru Nonaka, Shigetaka Yoshinaga, Takeshi Nakajima, Yutaka Saito
World J Gastroenterol
21(44):12635-12643.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12635
Abstract (958)
|
Core Tip (802)
|
Full Article (HTML) (3268)
|
Figures (1-5) (187)
|
Tables (1-4) (151)
|
Full Article (PDF)-1255K (605)
|
Peer-Review Report-158K (219)
|
Answering Reviewers-229K (282)
|
Received: 05/25/2015
|
Revised: 07/15/2015
|
Accepted: 09/30/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (29)
|
Total Visits (10912)
|
Similar Articles (198)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Chun-Lu Tan, Hao Zhang, Ke-Zhou Li
World J Gastroenterol
21(44):12644-12652.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12644
Abstract (884)
|
Core Tip (862)
|
Full Article (HTML) (2971)
|
Figures (1-7) (178)
|
Tables (1-4) (148)
|
Full Article (PDF)-1454K (513)
|
Peer-Review Report-109K (209)
|
Answering Reviewers-101K (181)
|
Received: 02/02/2015
|
Revised: 05/14/2015
|
Accepted: 08/31/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (16)
|
Total Visits (9911)
|
Similar Articles (89)
|
Timeline of Article Publication (1)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Yi-Lei Deng, Nan-Sheng Cheng, Shui-Jun Zhang, Wen-Jie Ma, Anuj Shrestha, Fu-Yu Li, Fei-Long Xu, Long-Shuan Zhao
World J Gastroenterol
21(44):12653-12659.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12653
Abstract (923)
|
Core Tip (897)
|
Full Article (HTML) (4767)
|
Figures (1-2) (410)
|
Tables (1-6) (140)
|
Full Article (PDF)-1088K (665)
|
Peer-Review Report-80K (195)
|
Answering Reviewers-118K (278)
|
Received: 01/02/2015
|
Revised: 08/26/2015
|
Accepted: 09/14/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (36)
|
Total Visits (11441)
|
Similar Articles (32)
|
Timeline of Article Publication (2)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Observational Study
João Santos-Antunes, Hélder Cardoso, Susana Lopes, Margarida Marques, Amadeu CR Nunes, Guilherme Macedo
World J Gastroenterol
21(44):12660-12666.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12660
Abstract (809)
|
Core Tip (794)
|
Full Article (HTML) (2677)
|
Figures (1-3) (152)
|
Tables (1-2) (144)
|
Full Article (PDF)-973K (490)
|
Peer-Review Report-82K (228)
|
Answering Reviewers-77K (185)
|
Received: 04/24/2015
|
Revised: 06/30/2015
|
Accepted: 08/31/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (11)
|
Total Visits (9564)
|
Similar Articles (183)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Prospective Study
Saifun Nahar, Atsushi Iraha, Akira Hokama, Ayako Uehara, Gretchen Parrott, Tetsuya Ohira, Masatoshi Kaida, Tetsu Kinjo, Takeshi Kinjo, Tetsuo Hirata, Nagisa Kinjo, Jiro Fujita
World J Gastroenterol
21(44):12667-12675.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12667
Abstract (854)
|
Core Tip (819)
|
Full Article (HTML) (3674)
|
Figures (1-8) (168)
|
Tables (1-1) (133)
|
Full Article (PDF)-1084K (546)
|
Peer-Review Report-107K (169)
|
Answering Reviewers-123K (203)
|
Received: 06/01/2015
|
Revised: 08/03/2015
|
Accepted: 09/30/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (15)
|
Total Visits (11037)
|
Similar Articles (387)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Padmavathy Amma Jayalekshmi, Soroush Hassani, Athira Nandakumar, Chihaya Koriyama, Paul Sebastian, Suminori Akiba
World J Gastroenterol
21(44):12676-12685.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12676
Abstract (1187)
|
Core Tip (991)
|
Full Article (HTML) (4120)
|
Tables (1-5) (155)
|
Full Article (PDF)-1003K (593)
|
Peer-Review Report-82K (188)
|
Answering Reviewers-213K (241)
|
Received: 04/20/2015
|
Revised: 07/13/2015
|
Accepted: 09/02/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (16)
|
Total Visits (12155)
|
Similar Articles (1056)
|
Timeline of Article Publication (1)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Systematic Reviews
Albert M Wolthuis, Gabriele Bislenghi, Anthony de Buck van Overstraeten, André D’Hoore
World J Gastroenterol
21(44):12686-12695.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12686
Abstract (1020)
|
Core Tip (1004)
|
Full Article (HTML) (3934)
|
Figures (1-1) (297)
|
Tables (1-3) (196)
|
Full Article (PDF)-972K (725)
|
Peer-Review Report-79K (211)
|
Answering Reviewers-93K (198)
|
Received: 05/16/2015
|
Revised: 08/01/2015
|
Accepted: 10/26/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (28)
|
Total Visits (11940)
|
Similar Articles (22)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Majid A Almadi, Helmut Neumann
World J Gastroenterol
21(44):12696-12708.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12696
Abstract (1003)
|
Core Tip (840)
|
Full Article (HTML) (4649)
|
Figures (1-4) (180)
|
Tables (1-2) (184)
|
Full Article (PDF)-1606K (511)
|
Peer-Review Report-98K (192)
|
Answering Reviewers-54K (179)
|
Received: 03/28/2015
|
Revised: 07/08/2015
|
Accepted: 09/14/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (5)
|
Total Visits (11297)
|
Similar Articles (4)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Case Report
Kevin M Riggle, Ghassan Wahbeh, Elizabeth M Williams, Kimberly J Riehle
World J Gastroenterol
21(44):12709-12712.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12709
Abstract (984)
|
Core Tip (837)
|
Full Article (HTML) (3117)
|
Figures (1-3) (349)
|
Full Article (PDF)-956K (501)
|
Peer-Review Report-78K (201)
|
Answering Reviewers-172K (211)
|
Received: 03/26/2015
|
Revised: 06/04/2015
|
Accepted: 09/02/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (8)
|
Total Visits (10361)
|
Similar Articles (31)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Mihajlo Gjeorgjievski, Mitual B Amin, Mitchell S Cappell
World J Gastroenterol
21(44):12713-12721.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12713
Abstract (867)
|
Core Tip (791)
|
Full Article (HTML) (3405)
|
Figures (1-2) (224)
|
Tables (1-2) (165)
|
Full Article (PDF)-1312K (460)
|
Peer-Review Report-70K (231)
|
Answering Reviewers-198K (145)
|
Received: 06/01/2015
|
Revised: 07/13/2015
|
Accepted: 08/31/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (5)
|
Total Visits (10312)
|
Similar Articles (29)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Nobuyoshi Takeshita, Toru Fukunaga, Masayuki Kimura, Yuji Sugamoto, Kentaro Tasaki, Isamu Hoshino, Takumi Ota, Tetsuro Maruyama, Tomohide Tamachi, Takashi Hosokawa, Yo Asai, Hisahiro Matsubara
World J Gastroenterol
21(44):12722-12728.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12722
Abstract (927)
|
Core Tip (858)
|
Full Article (HTML) (4365)
|
Figures (1-5) (372)
|
Full Article (PDF)-1345K (455)
|
Peer-Review Report-91K (146)
|
Answering Reviewers-90K (161)
|
Received: 03/19/2015
|
Revised: 08/17/2015
|
Accepted: 09/14/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (3)
|
Total Visits (11525)
|
Similar Articles (176)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Chih-Yang Hsiao, Cheng-Maw Ho, Yao-Ming Wu, Ming-Chih Ho, Rey-Heng Hu, Po-Huang Lee
World J Gastroenterol
21(44):12729-12734.
Published online Nov 28, 2015.
doi: 10.3748/wjg.v21.i44.12729
Abstract (803)
|
Core Tip (842)
|
Full Article (HTML) (5266)
|
Figures (1-3) (197)
|
Tables (1-1) (151)
|
Full Article (PDF)-1041K (543)
|
Peer-Review Report-86K (179)
|
Answering Reviewers-116K (239)
|
Received: 05/20/2015
|
Revised: 06/23/2015
|
Accepted: 08/31/2015
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (9)
|
Total Visits (12979)
|
Similar Articles (461)
|
Timeline of Article Publication (0)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open