Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2015; 21(43): 12410-12420
Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12410
Comparison of selected inflammation-based prognostic markers in relapsed or refractory metastatic colorectal cancer patients
Anna Song, Wankyu Eo, Sookyung Lee
Anna Song, Sookyung Lee, Department of Clinical Oncology, College of Korean Medicine, Kyung Hee University, Seoul 134-727, South Korea
Wankyu Eo, Department of Medical Oncology, College of Medicine, Kyung Hee University, Seoul 134-727, South Korea
Author contributions: Song A analyzed the data and wrote the draft of manuscript; Eo W suggested the research hypothesis and advised on statistical analyses; Lee S performed the research setup and critically revised the manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Kyung Hee University Hospital at Gangdong (KHNMC-OH-IRB 2013-010).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment before initiation of treatment.
Conflict-of-interest statement: We have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sookyung Lee, KMD, PhD, Associate Professor, Department of Clinical Oncology, College of Korean Medicine, Kyung Hee University, 892 Dongnam-ro, Gangdong-gu, Seoul 134-727, South Korea. sookyung@khu.ac.kr
Telephone: +82-2-4406229 Fax: +82-2-4407267
Received: March 21, 2015
Peer-review started: March 23, 2015
First decision: June 19, 2015
Revised: June 30, 2015
Accepted: September 2, 2015
Article in press: September 2, 2015
Published online: November 21, 2015
Core Tip

Core tip: This is a retrospective study to compare the systemic inflammation based prognostic markers in relapsed or refractory metastatic colorectal cancer (mCRC) patients. We reviewed the medical records of 177 mCRC patients and analyzed the impact of systemic inflammation markers including modified Glasgow prognostic score (mGPS), neutrophil lymphocyte ratio, platelet lymphocyte ratio, lymphocyte monocyte ratio (LMR), and prognostic nutritional index on survival time. The mGPS and LMR were the best inflammatory markers for predicting overall survival time in relapsed or refractory mCRC patients.