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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Conflicts of interest in nutritional sciences: The forgotten bias in meta-analysis  
Michel Lucas 
World J Methodol 5(4):175-178. Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.175
2
Helicobacter pylori and allergy: Update of research  
Ilva Daugule, Jelizaveta Zavoronkova, Daiga Santare 
World J Methodol 5(4):203-211. Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.203
3
Predictive power of statistical significance  
Thomas F Heston, Jackson M King 
World J Methodol 7(4):112-116. Published online Dec 26, 2017. doi: 10.5662/wjm.v7.i4.112
4
Methods for the extraction and RNA profiling of exosomes  
Emily Zeringer, Mu Li, Tim Barta, Jeoffrey Schageman, Ketil Winther Pedersen, Axl Neurauter, Susan Magdaleno, Robert Setterquist, Alexander V Vlassov 
World J Methodol 3(1):11-18. Published online Mar 26, 2013. doi: 10.5662/wjm.v3.i1.11
5
Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology  
Bram Smarius, Charlotte Loozen, Wendy Manten, Mireille Bekker, Lou Pistorius, Corstiaan Breugem 
World J Methodol 7(3):93-100. Published online Sep 26, 2017. doi: 10.5662/wjm.v7.i3.93
6
Prevalence of antibiotic resistance in Helicobacter pylori: A recent literature review  
Reza Ghotaslou, Hamed Ebrahimzadeh Leylabadlo, Yalda Mohammadzadeh Asl 
World J Methodol 5(3):164-174. Published online Sep 26, 2015. doi: 10.5662/wjm.v5.i3.164
7
Patch testing and cross sensitivity study of adverse cutaneous drug reactions due to anticonvulsants: A preliminary report  
T N Shiny, Vikram K Mahajan, Karaninder S Mehta, Pushpinder S Chauhan, Ritu Rawat, Rajni Sharma 
World J Methodol 7(1):25-32. Published online Mar 26, 2017. doi: 10.5662/wjm.v7.i1.25
8
New developments and controversies in iron metabolism and iron chelation therapy  
Christina N Kontoghiorghe, George J Kontoghiorghes 
World J Methodol 6(1):1-19. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.1
9
Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms  
Frank NM Twisk 
World J Methodol 5(2):68-87. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.68
10
Clinical development of reovirus for cancer therapy: An oncolytic virus with immune-mediated antitumor activity  
Jun Gong, Esha Sachdev, Alain C Mita, Monica M Mita 
World J Methodol 6(1):25-42. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.25
11
Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases  
Annita Kolnagou, Christina N Kontoghiorghe, George J Kontoghiorghes 
World J Methodol 4(4):197-218. Published online Dec 26, 2014. doi: 10.5662/wjm.v4.i4.197
12
Cross-reactivity between aeroallergens and food allergens  
Florin-Dan Popescu 
World J Methodol 5(2):31-50. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.31
13
Targeted temperature management in neurological intensive care unit  
Sombat Muengtaweepongsa, Winchana Srivilaithon 
World J Methodol 7(2):55-67. Published online Jun 26, 2017. doi: 10.5662/wjm.v7.i2.55
14
Role of metabolic stress for enhancing muscle adaptations: Practical applications  
Marcelo Conrado de Freitas, Jose Gerosa-Neto, Nelo Eidy Zanchi, Fabio Santos Lira, Fabrício Eduardo Rossi 
World J Methodol 7(2):46-54. Published online Jun 26, 2017. doi: 10.5662/wjm.v7.i2.46
15
Effects of physical activity in Parkinson's disease: A new tool for rehabilitation  
Paolo Borrione, Eliana Tranchita, Pierpaolo Sansone, Attilio Parisi 
World J Methodol 4(3):133-143. Published online Sep 26, 2014. doi: 10.5662/wjm.v4.i3.133
16
Footwear modification following hallux valgus surgery: The all-or-none phenomenon  
Cal Robinson, Abhijit Bhosale, Anand Pillai 
World J Methodol 6(2):171-180. Published online Jun 26, 2016. doi: 10.5662/wjm.v6.i2.171
17
Profile and determinants of unsuccessful tuberculosis outcome in rural Nigeria: Implications for tuberculosis control  
Kingsley N Ukwaja, Sarah N Oshi, Isaac Alobu, Daniel C Oshi 
World J Methodol 6(1):118-125. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.118
18
Dissolution mechanism of calcium apatites in acids: A review of literature  
Sergey V Dorozhkin 
World J Methodol 2(1):1-17. Published online Feb 26, 2012. doi: 10.5662/wjm.v2.i1.1
19
World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients  
Christina N Kontoghiorghe, Nicholas Andreou, Katerina Constantinou, George J Kontoghiorghes 
World J Methodol 4(3):163-188. Published online Sep 26, 2014. doi: 10.5662/wjm.v4.i3.163
20
Cation-exchange high-performance liquid chromatography for variant hemoglobins and HbF/A2: What must hematopathologists know about methodology?  
Prashant Sharma, Reena Das 
World J Methodol 6(1):20-24. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.20
21
Chromogranin A as a valid marker in oncology: Clinical application or false hopes?  
Stavros Gkolfinopoulos, Konstantinos Tsapakidis, Konstantinos Papadimitriou, Demetris Papamichael, Panteleimon Kountourakis 
World J Methodol 7(1):9-15. Published online Mar 26, 2017. doi: 10.5662/wjm.v7.i1.9
22
Past, present and future of cyanide antagonism research: From the early remedies to the current therapies  
Ilona Petrikovics, Marianna Budai, Kristof Kovacs, David E Thompson 
World J Methodol 5(2):88-100. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.88
23
Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder  
Marlein Miranda Cona, Yewei Liu, Ting Yin, Yuanbo Feng, Feng Chen, Stefaan Mulier, Yue Li, Jian Zhang, Raymond Oyen, Yicheng Ni 
World J Methodol 6(2):154-162. Published online Jun 26, 2016. doi: 10.5662/wjm.v6.i2.154
24
25
“How many times must a man look up before he can really see the sky?” Rheumatic cardiovascular disease in the era of multimodality imaging  
Sophie I Mavrogeni, George Markousis-Mavrogenis, David Hautemann, Kees van Wijk, Hans J Reiber, Genovefa Kolovou 
World J Methodol 5(3):136-143. Published online Sep 26, 2015. doi: 10.5662/wjm.v5.i3.136
26
Lamb’s head: The model for novice education in endoscopic sinus surgery  
Neven Skitarelić, Ranko Mladina 
World J Methodol 5(3):144-148. Published online Sep 26, 2015. doi: 10.5662/wjm.v5.i3.144
27
Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy  
Laura Petrarca, Raffaella Nenna, Gerarda Mastrogiorgio, Matteo Florio, Manuela Brighi, Stefano Pontone 
World J Methodol 4(3):189-196. Published online Sep 26, 2014. doi: 10.5662/wjm.v4.i3.189
28
Towards automated calculation of evidence-based clinical scores  
Christopher A Aakre, Mikhail A Dziadzko, Vitaly Herasevich 
World J Methodol 7(1):16-24. Published online Mar 26, 2017. doi: 10.5662/wjm.v7.i1.16
29
Biomarkers of oxidative stress in erythrocytes as a function of human age  
Pawan Kumar Maurya, Prabhanshu Kumar, Pranjal Chandra 
World J Methodol 5(4):216-222. Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.216
30
Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer  
Crystal C Lipsey, Adriana Harbuzariu, Danielle Daley-Brown, Ruben R Gonzalez-Perez 
World J Methodol 6(1):43-55. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.43
31
Methodical and pre-analytical characteristics of a multiplex cancer biomarker immunoassay  
Natalie Hermann, Katja Dreßen, Frank A Schildberg, Christopher Jakobs, Stefan Holdenrieder 
World J Methodol 4(4):219-231. Published online Dec 26, 2014. doi: 10.5662/wjm.v4.i4.219
32
Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?  
George Vaos, Nick Zavras 
World J Methodol 7(2):37-45. Published online Jun 26, 2017. doi: 10.5662/wjm.v7.i2.37
33
Potential effects of curcumin on peroxisome proliferator-activated receptor-γ in vitro and in vivo  
Mohsen Mazidi, Ehsan Karimi, Mohsen Meydani, Majid Ghayour-Mobarhan, Gordon A Ferns 
World J Methodol 6(1):112-117. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.112
34
35
Study design in evidence-based surgery: What is the role of case-control studies?  
Amy M Cao, Michael R Cox, Guy D Eslick 
World J Methodol 6(1):101-104. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.101
36
Vascular targeted photochemotherapy using padoporfin and padeliporfin as a method of the focal treatment of localised prostate cancer - clinician’s insight  
Andrzej M Bugaj 
World J Methodol 6(1):65-76. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.65
37
38
Metabolic bone disease in the preterm infant: Current state and future directions  
Moghis Ur Rehman, Hassib Narchi 
World J Methodol 5(3):115-121. Published online Sep 26, 2015. doi: 10.5662/wjm.v5.i3.115
39
Laparoscopic surgery: A qualified systematic review  
Alexander Buia, Florian Stockhausen, Ernst Hanisch 
World J Methodol 5(4):238-254. Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.238
40
41
Recurrent urinary tract infections in children: Preventive interventions other than prophylactic antibiotics  
Kishor Tewary, Hassib Narchi 
World J Methodol 5(2):13-19. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.13
42
Non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management  
Dimitri Poddighe, Matteo Gelardi, Amelia Licari, Michele Miraglia del Giudice, Gian Luigi Marseglia 
World J Methodol 6(4):200-213. Published online Dec 26, 2016. doi: 10.5662/wjm.v6.i4.200
43
Methods, units and quality requirements for the analysis of haemoglobin A1c in diabetes mellitus  
Ilkka Penttilä, Karri Penttilä, Päivi Holm, Harri Laitinen, Päivi Ranta, Jukka Törrönen, Rainer Rauramaa 
World J Methodol 6(2):133-142. Published online Jun 26, 2016. doi: 10.5662/wjm.v6.i2.133
44
45
Efficient management and maintenance of ultrasonic nebulizers to prevent microbial contamination  
Yoko Ida, Hiroaki Ohnishi, Kouji Araki, Ryoichi Saito, Shin Kawai, Takashi Watanabe 
World J Methodol 6(1):126-132. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.126
46
Radiological clinical trials: Proposal of a problem-finding questionnaire to improve study success  
Francesca Valdora, Bianca Bignotti, Massimo Calabrese, Nehmat Houssami, Alberto Tagliafico 
World J Methodol 6(4):214-219. Published online Dec 26, 2016. doi: 10.5662/wjm.v6.i4.214
47
CD4-positive diffuse large B-cell lymphoma: A variant with aggressive clinical potential  
Mohammad O Hussaini, Friederike H Kreisel, Anjum Hassan, TuDung T Nguyen, John L Frater 
World J Methodol 6(3):181-186. Published online Sep 26, 2016. doi: 10.5662/wjm.v6.i3.181
48
Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate  
Ahmed Alaini, Deepak Malhotra, Helbert Rondon-Berrios, Christos P Argyropoulos, Zeid J Khitan, Dominic S C Raj, Mark Rohrscheib, Joseph I Shapiro, Antonios H Tzamaloukas 
World J Methodol 7(3):73-92. Published online Sep 26, 2017. doi: 10.5662/wjm.v7.i3.73
49
Bartter and Gitelman syndromes: Spectrum of clinical manifestations caused by different mutations  
Amar Al Shibli, Hassib Narchi 
World J Methodol 5(2):55-61. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.55
50
Clinical neurological examination vs electrophysiological studies: Reflections from experiences in occupational medicine  
Jørgen Riis Jepsen 
World J Methodol 5(2):26-30. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.26