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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
Predictive power of statistical significance  
Thomas F Heston, Jackson M King 
World J Methodol 7(4):112-116. Published online Dec 26, 2017. doi: 10.5662/wjm.v7.i4.112
Helicobacter pylori and allergy: Update of research  
Ilva Daugule, Jelizaveta Zavoronkova, Daiga Santare 
World J Methodol 5(4):203-211. Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.203
Conflicts of interest in nutritional sciences: The forgotten bias in meta-analysis  
Michel Lucas 
World J Methodol 5(4):175-178. Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.175
Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology  
Bram Smarius, Charlotte Loozen, Wendy Manten, Mireille Bekker, Lou Pistorius, Corstiaan Breugem 
World J Methodol 7(3):93-100. Published online Sep 26, 2017. doi: 10.5662/wjm.v7.i3.93
Cross-reactivity between aeroallergens and food allergens  
Florin-Dan Popescu 
World J Methodol 5(2):31-50. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.31
Targeted temperature management in neurological intensive care unit  
Sombat Muengtaweepongsa, Winchana Srivilaithon 
World J Methodol 7(2):55-67. Published online Jun 26, 2017. doi: 10.5662/wjm.v7.i2.55
Role of metabolic stress for enhancing muscle adaptations: Practical applications  
Marcelo Conrado de Freitas, Jose Gerosa-Neto, Nelo Eidy Zanchi, Fabio Santos Lira, Fabrício Eduardo Rossi 
World J Methodol 7(2):46-54. Published online Jun 26, 2017. doi: 10.5662/wjm.v7.i2.46
Prevalence of antibiotic resistance in Helicobacter pylori: A recent literature review  
Reza Ghotaslou, Hamed Ebrahimzadeh Leylabadlo, Yalda Mohammadzadeh Asl 
World J Methodol 5(3):164-174. Published online Sep 26, 2015. doi: 10.5662/wjm.v5.i3.164
Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms  
Frank NM Twisk 
World J Methodol 5(2):68-87. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.68
Methods for the extraction and RNA profiling of exosomes  
Emily Zeringer, Mu Li, Tim Barta, Jeoffrey Schageman, Ketil Winther Pedersen, Axl Neurauter, Susan Magdaleno, Robert Setterquist, Alexander V Vlassov 
World J Methodol 3(1):11-18. Published online Mar 26, 2013. doi: 10.5662/wjm.v3.i1.11
Clinical development of reovirus for cancer therapy: An oncolytic virus with immune-mediated antitumor activity  
Jun Gong, Esha Sachdev, Alain C Mita, Monica M Mita 
World J Methodol 6(1):25-42. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.25
Patch testing and cross sensitivity study of adverse cutaneous drug reactions due to anticonvulsants: A preliminary report  
T N Shiny, Vikram K Mahajan, Karaninder S Mehta, Pushpinder S Chauhan, Ritu Rawat, Rajni Sharma 
World J Methodol 7(1):25-32. Published online Mar 26, 2017. doi: 10.5662/wjm.v7.i1.25
Dissolution mechanism of calcium apatites in acids: A review of literature  
Sergey V Dorozhkin 
World J Methodol 2(1):1-17. Published online Feb 26, 2012. doi: 10.5662/wjm.v2.i1.1
Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder  
Marlein Miranda Cona, Yewei Liu, Ting Yin, Yuanbo Feng, Feng Chen, Stefaan Mulier, Yue Li, Jian Zhang, Raymond Oyen, Yicheng Ni 
World J Methodol 6(2):154-162. Published online Jun 26, 2016. doi: 10.5662/wjm.v6.i2.154
New developments and controversies in iron metabolism and iron chelation therapy  
Christina N Kontoghiorghe, George J Kontoghiorghes 
World J Methodol 6(1):1-19. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.1
Profile and determinants of unsuccessful tuberculosis outcome in rural Nigeria: Implications for tuberculosis control  
Kingsley N Ukwaja, Sarah N Oshi, Isaac Alobu, Daniel C Oshi 
World J Methodol 6(1):118-125. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.118
Risk stratification for coronary artery disease in multi-ethnic populations: Are there broader considerations for cost efficiency?  
Pupalan Iyngkaran, William Chan, Danny Liew, Jalal Zamani, John D Horowitz, Michael Jelinek, David L Hare, James A Shaw 
World J Methodol 9(1):1-19. Published online Jan 18, 2019. doi: 10.5662/wjm.v9.i1.1
Chromogranin A as a valid marker in oncology: Clinical application or false hopes?  
Stavros Gkolfinopoulos, Konstantinos Tsapakidis, Konstantinos Papadimitriou, Demetris Papamichael, Panteleimon Kountourakis 
World J Methodol 7(1):9-15. Published online Mar 26, 2017. doi: 10.5662/wjm.v7.i1.9
World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients  
Christina N Kontoghiorghe, Nicholas Andreou, Katerina Constantinou, George J Kontoghiorghes 
World J Methodol 4(3):163-188. Published online Sep 26, 2014. doi: 10.5662/wjm.v4.i3.163
Footwear modification following hallux valgus surgery: The all-or-none phenomenon  
Cal Robinson, Abhijit Bhosale, Anand Pillai 
World J Methodol 6(2):171-180. Published online Jun 26, 2016. doi: 10.5662/wjm.v6.i2.171
Effects of physical activity in Parkinson's disease: A new tool for rehabilitation  
Paolo Borrione, Eliana Tranchita, Pierpaolo Sansone, Attilio Parisi 
World J Methodol 4(3):133-143. Published online Sep 26, 2014. doi: 10.5662/wjm.v4.i3.133
Study design in evidence-based surgery: What is the role of case-control studies?  
Amy M Cao, Michael R Cox, Guy D Eslick 
World J Methodol 6(1):101-104. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.101
Cation-exchange high-performance liquid chromatography for variant hemoglobins and HbF/A2: What must hematopathologists know about methodology?  
Prashant Sharma, Reena Das 
World J Methodol 6(1):20-24. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.20
Non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management  
Dimitri Poddighe, Matteo Gelardi, Amelia Licari, Michele Miraglia del Giudice, Gian Luigi Marseglia 
World J Methodol 6(4):200-213. Published online Dec 26, 2016. doi: 10.5662/wjm.v6.i4.200
Towards automated calculation of evidence-based clinical scores  
Christopher A Aakre, Mikhail A Dziadzko, Vitaly Herasevich 
World J Methodol 7(1):16-24. Published online Mar 26, 2017. doi: 10.5662/wjm.v7.i1.16
Is forced oscillation technique the next respiratory function test of choice in childhood asthma  
Afaf Alblooshi, Alia Alkalbani, Ghaya Albadi, Hassib Narchi, Graham Hall 
World J Methodol 7(4):129-138. Published online Dec 26, 2017. doi: 10.5662/wjm.v7.i4.129
Biomarkers of oxidative stress in erythrocytes as a function of human age  
Pawan Kumar Maurya, Prabhanshu Kumar, Pranjal Chandra 
World J Methodol 5(4):216-222. Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.216
Laparoscopic surgery: A qualified systematic review  
Alexander Buia, Florian Stockhausen, Ernst Hanisch 
World J Methodol 5(4):238-254. Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.238
Potential effects of curcumin on peroxisome proliferator-activated receptor-γ in vitro and in vivo  
Mohsen Mazidi, Ehsan Karimi, Mohsen Meydani, Majid Ghayour-Mobarhan, Gordon A Ferns 
World J Methodol 6(1):112-117. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.112
Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases  
Annita Kolnagou, Christina N Kontoghiorghe, George J Kontoghiorghes 
World J Methodol 4(4):197-218. Published online Dec 26, 2014. doi: 10.5662/wjm.v4.i4.197
Past, present and future of cyanide antagonism research: From the early remedies to the current therapies  
Ilona Petrikovics, Marianna Budai, Kristof Kovacs, David E Thompson 
World J Methodol 5(2):88-100. Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.88
Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer  
Crystal C Lipsey, Adriana Harbuzariu, Danielle Daley-Brown, Ruben R Gonzalez-Perez 
World J Methodol 6(1):43-55. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.43
Radiological clinical trials: Proposal of a problem-finding questionnaire to improve study success  
Francesca Valdora, Bianca Bignotti, Massimo Calabrese, Nehmat Houssami, Alberto Tagliafico 
World J Methodol 6(4):214-219. Published online Dec 26, 2016. doi: 10.5662/wjm.v6.i4.214
Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate  
Ahmed Alaini, Deepak Malhotra, Helbert Rondon-Berrios, Christos P Argyropoulos, Zeid J Khitan, Dominic S C Raj, Mark Rohrscheib, Joseph I Shapiro, Antonios H Tzamaloukas 
World J Methodol 7(3):73-92. Published online Sep 26, 2017. doi: 10.5662/wjm.v7.i3.73
Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?  
George Vaos, Nick Zavras 
World J Methodol 7(2):37-45. Published online Jun 26, 2017. doi: 10.5662/wjm.v7.i2.37
Statistical models for meta-analysis: A brief tutorial  
George A Kelley, Kristi S Kelley 
World J Methodol 2(4):27-32. Published online Aug 26, 2012. doi: 10.5662/wjm.v2.i4.27
Vascular targeted photochemotherapy using padoporfin and padeliporfin as a method of the focal treatment of localised prostate cancer - clinician’s insight  
Andrzej M Bugaj 
World J Methodol 6(1):65-76. Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.65
Assessment of quality control system by sigma metrics and quality goal index ratio: A roadmap towards preparation for NABL  
Monica Verma, Kiran Dahiya, Veena Singh Ghalaut, Vasudha Dhupper 
World J Methodol 8(3):44-50. Published online Nov 29, 2018. doi: 10.5662/wjm.v8.i3.44
Microembolic signal detection by transcranial Doppler: Old method with a new indication  
Sombat Muengtaweepongsa, Charturong Tantibundhit 
World J Methodol 8(3):40-43. Published online Nov 29, 2018. doi: 10.5662/wjm.v8.i3.40
“How many times must a man look up before he can really see the sky?” Rheumatic cardiovascular disease in the era of multimodality imaging  
Sophie I Mavrogeni, George Markousis-Mavrogenis, David Hautemann, Kees van Wijk, Hans J Reiber, Genovefa Kolovou 
World J Methodol 5(3):136-143. Published online Sep 26, 2015. doi: 10.5662/wjm.v5.i3.136
Metabolic bone disease in the preterm infant: Current state and future directions  
Moghis Ur Rehman, Hassib Narchi 
World J Methodol 5(3):115-121. Published online Sep 26, 2015. doi: 10.5662/wjm.v5.i3.115
Lamb’s head: The model for novice education in endoscopic sinus surgery  
Neven Skitarelić, Ranko Mladina 
World J Methodol 5(3):144-148. Published online Sep 26, 2015. doi: 10.5662/wjm.v5.i3.144
Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules  
Florin-Dan Popescu, Mariana Vieru 
World J Methodol 8(3):17-36. Published online Nov 29, 2018. doi: 10.5662/wjm.v8.i3.17
Methodical and pre-analytical characteristics of a multiplex cancer biomarker immunoassay  
Natalie Hermann, Katja Dreßen, Frank A Schildberg, Christopher Jakobs, Stefan Holdenrieder 
World J Methodol 4(4):219-231. Published online Dec 26, 2014. doi: 10.5662/wjm.v4.i4.219
Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy  
Laura Petrarca, Raffaella Nenna, Gerarda Mastrogiorgio, Matteo Florio, Manuela Brighi, Stefano Pontone 
World J Methodol 4(3):189-196. Published online Sep 26, 2014. doi: 10.5662/wjm.v4.i3.189