Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Nov 29, 2018; 8(3): 17-36
Published online Nov 29, 2018. doi: 10.5662/wjm.v8.i3.17
Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules
Florin-Dan Popescu, Mariana Vieru
Florin-Dan Popescu, Mariana Vieru, Department of Allergology, “Carol Davila” University of Medicine and Pharmacy, Bucharest 022441, Romania
Florin-Dan Popescu, Mariana Vieru, Department of Allergology and Clinical Immunology, “Nicolae Malaxa” Clinical Hospital, Bucharest 022441, Romania
Author contributions: Popescu FD and Vieru M conceived the editorial and drafted the manuscript; both authors approved the final version of the article.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author to: Florin-Dan Popescu, MD, PhD, Associate Professor, Chief Doctor, Department of Allergology and Clinical Immunology, “Nicolae Malaxa” Clinical Hospital, Sos Vergului 12, Sector 2, Bucharest 022441, Romania. florindanpopescu@ymail.com
Telephone: +40-212-555405 Fax: + 40-212-555275
Received: July 9, 2018
Peer-review started: July 9, 2018
First decision: August 2, 2018
Revised: August 9, 2018
Accepted: October 9, 2018
Article in press: October 9, 2018
Published online: November 29, 2018
Core Tip

Core tip: Allergic respiratory diseases affect many people of all ages worldwide, showing increased prevalence, severity and complexity. New generation immunoassays using allergenic molecules represent a great precision medicine approach in research and clinical practice, allowing in vitro assessment of the immunoglobulin E (IgE) sensitization pattern at the molecular level, with favorable impact on allergy diagnosis and treatment, especially in selected patients with multiple aeroallergen sensitizations. The choice for a specific IgE immunoassay (singleplex, multiparameter or multiplex) for the allergenic extracts and molecular specificities, and the correct interpretation of the results, require optimal knowledge of the tests’ methodologies and characteristics, and good clinical judgments.