Published online Nov 29, 2018. doi: 10.5662/wjm.v8.i3.17
Peer-review started: July 9, 2018
First decision: August 2, 2018
Revised: August 9, 2018
Accepted: October 9, 2018
Article in press: October 9, 2018
Published online: November 29, 2018
Core tip: Allergic respiratory diseases affect many people of all ages worldwide, showing increased prevalence, severity and complexity. New generation immunoassays using allergenic molecules represent a great precision medicine approach in research and clinical practice, allowing in vitro assessment of the immunoglobulin E (IgE) sensitization pattern at the molecular level, with favorable impact on allergy diagnosis and treatment, especially in selected patients with multiple aeroallergen sensitizations. The choice for a specific IgE immunoassay (singleplex, multiparameter or multiplex) for the allergenic extracts and molecular specificities, and the correct interpretation of the results, require optimal knowledge of the tests’ methodologies and characteristics, and good clinical judgments.