Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder
Marlein Miranda Cona, Yewei Liu, Ting Yin, Yuanbo Feng, Feng Chen, Stefaan Mulier, Yue Li, Jian Zhang, Raymond Oyen, Yicheng Ni
Marlein Miranda Cona, Yewei Liu, Ting Yin, Yuanbo Feng, Feng Chen, Stefaan Mulier, Raymond Oyen, Yicheng Ni, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, 3000 Leuven, Belgium
Stefaan Mulier, Department of Surgery, Leopold Park Clinic, CHIREC Cancer Institute, 1040 Brussels, Belgium
Yue Li, Jian Zhang, Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, China
Author contributions: Miranda Cona M, Liu Y, Yin T, Feng Y, Chen F, Li Y, Zhang J and Ni Y carried out all the experiments, did data analysis and manuscript writing; Mulier S contributed to collecting gallstones from patients, concept designing and manuscript writing; Oyen R contributed to concept designing, technical and financial support, and final approval for submission.
Supported by Flanders Research Foundation (FWO-42865); the KU Leuven Molecular Small Animal Imaging Center MoSAIC (KUL EF/05/08); the center of excellence in vivo molecular imaging research (IMIR); KU Leuven projects IOF-HB/08/009 and IOF-HB/12/018; the European Union (Asia-Link CfP 2006-EuropeAid/123738/C/ACT/Multi-Proposal No. 128-498/111); the National Natural Science Foundation of China No. 81071828; and Jiangsu Province Natural Science Foundation No. BK2010594. The corresponding author is currently a Bayer Lecture Chair holder.
Institutional review board statement: This experimental research was approved by the Ethical Committee of Medical School, KU Leuven, Belgium.
Conflict-of-interest statement: None of the authors have any conflict of interest.
Data sharing statement: No additional data available for this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Yicheng Ni, MD, PhD, Professor, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. yicheng.ni@med.kuleuven.be
Telephone: +32-16-322752 Fax: +32-16-343765
Received: March 22, 2016
Peer-review started: March 22, 2016
First decision: April 15, 2016
Revised: April 20, 2016
Accepted: May 31, 2016
Article in press: June 2, 2016
Published online: June 26, 2016
