Sarkari B, Rezaei Z. Immunodiagnosis of human hydatid disease: Where do we stand? World J Methodol 2015; 5(4): 185-195 [PMID: 26713278 DOI: 10.5662/wjm.v5.i4.185]
Corresponding Author of This Article
Bahador Sarkari, PhD, Professor of Immunoparasitology, Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Zand Street, Building No. 3, Shiraz 71345-1735, Iran. sarkarib@sums.ac.ir
Research Domain of This Article
Parasitology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Methodol. Dec 26, 2015; 5(4): 185-195 Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.185
Immunodiagnosis of human hydatid disease: Where do we stand?
Bahador Sarkari, Zahra Rezaei
Bahador Sarkari, Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz 71345-1735, Iran
Zahra Rezaei, Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71345-1735, Iran
Author contributions: Sarkari B performed the literature search, wrote the first draft of the manuscript, edited and approved the final version; Rezaei Z performed the literature and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bahador Sarkari, PhD, Professor of Immunoparasitology, Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Zand Street, Building No. 3, Shiraz 71345-1735, Iran. sarkarib@sums.ac.ir
Telephone: +98-71-32305291 Fax: +98-71-32305291
Received: August 4, 2015 Peer-review started: August 6, 2015 First decision: September 22, 2015 Revised: October 26, 2015 Accepted: November 13, 2015 Article in press: November 17, 2015 Published online: December 26, 2015
Core Tip
Core tip: Cystic echinococcosis (CE) (hydatid cyst) is one of the most important parasitic diseases, causing tremendous morbidity and mortality for the human patients. Diagnosis of CE mainly relies on ultrasound images of the cyst along with serological testing. So far, there is no highly specific and sensitive immunodiagnostic test for diagnosis of CE and performances of the currently available tests are not satisfactory. Different antigenic sources including hydatid cyst fluid, antigen B and 5, excretory-secretory antigens of larval stage or adult worm have widely been used for development of serological assays for diagnosis of CE. Utilizing of antigen B subunits in immunodiagnostic tests and detection of IgG subclasses, as a good marker, opened a promising perspective in diagnosis of this debilitating disease.
