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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Inhibitors of glucose transport and glycolysis as novel anticancer therapeutics  
Yanrong Qian, Xuan Wang, Xiaozhuo Chen 
World J Transl Med 3(2):37-57. Published online Aug 12, 2014. doi: 10.5528/wjtm.v3.i2.37
2
Arsenic-induced abnormalities in glucose metabolism: Biochemical basis and potential therapeutic and nutritional interventions  
Archana Kulshrestha, Urmila Jarouliya, GBKS Prasad, SJS Flora, Prakash S Bisen 
World J Transl Med 3(2):96-111. Published online Aug 12, 2014. doi: 10.5528/wjtm.v3.i2.96
3
New categorization of human vascular endothelial cells by pro- vs anti-proliferative phenotypes  
Miwako Nishio, Masako Nakahara, Chikako Sato, Koichi Saeki, Hidenori Akutsu, Akihiro Umezawa, Kazuyuki Tobe, Kazuki Yasuda, Akira Yuo, Kumiko Saeki 
World J Transl Med 4(3):88-100. Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.88
4
Epigenetics and DNA methylation in cancer  
Laura Lattanzio, Cristiana Lo Nigro 
World J Transl Med 4(1):11-24. Published online Apr 12, 2015. doi: 10.5528/wjtm.v4.i1.11
5
Gene editing for corneal disease management  
Sudhanshu P Raikwar, Apoorva S Raikwar, Shyam S Chaurasia, Rajiv R Mohan 
World J Transl Med 5(1):1-13. Published online Apr 12, 2016. doi: 10.5528/wjtm.v5.i1.1
6
Scope of translational medicine in developing boron-containing compounds for therapeutics  
Ana Karen García-Ávila, Eunice Dalet Farfán-García, Juan Alberto Guevara-Salazar, José Guadalupe Trujillo-Ferrara, Marvin Antonio Soriano-Ursúa 
World J Transl Med 6(1):1-9. Published online Apr 12, 2017. doi: 10.5528/wjtm.v6.i1.1
7
Obesity research: Status quo and future outlooks  
Alexander T El Gammal, Anna Dupree, Stefan Wolter, Jens Aberle, Jakob R Izbicki, Cenap Güngör, Oliver Mann 
World J Transl Med 3(3):119-132. Published online Dec 12, 2014. doi: 10.5528/wjtm.v3.i3.119
8
Concepts of body constitution, health and sub-health from traditional Chinese medicine perspective  
Rose YP Chan, Wai Tong Chien 
World J Transl Med 2(3):56-66. Published online Dec 12, 2013. doi: 10.5528/wjtm.v2.i3.56
9
Pharmacogenetics of type 2 diabetes mellitus: An example of success in clinical and translational medicine  
Antonio Brunetti, Francesco S Brunetti, Eusebio Chiefari 
World J Transl Med 3(3):141-149. Published online Dec 12, 2014. doi: 10.5528/wjtm.v3.i3.141
10
Neurological and behavioral manifestations of cerebral malaria: An update  
Marta Chagas Monteiro, Fabio Rodrigues Oliveira, Gedeao Batista Oliveira, Pedro Roosevelt Torres Romao, Cristiane Socorro Ferraz Maia 
World J Transl Med 3(1):9-16. Published online Apr 12, 2014. doi: 10.5528/wjtm.v3.i1.9
11
Assessment of platelet function: Laboratory and point-of-care methods  
Rita Paniccia, Raffaella Priora, Agatina Alessandrello Liotta, Niccolò Maggini, Rosanna Abbate 
World J Transl Med 3(2):69-83. Published online Aug 12, 2014. doi: 10.5528/wjtm.v3.i2.69
12
New insights in sperm biology: How benchside results in the search for molecular markers may help understand male infertility  
Sara Marchiani, Lara Tamburrino, Monica Muratori, Elisabetta Baldi 
World J Transl Med 5(1):26-36. Published online Apr 12, 2016. doi: 10.5528/wjtm.v5.i1.26
13
Pro- vs anti-stenotic capacities of type-I vs type-II human induced pluripotent-derived endothelial cells  
Miwako Nishio, Masako Nakahara, Koichi Saeki, Katsuhito Fujiu, Hiroshi Iwata, Ichiro Manabe, Akira Yuo, Kumiko Saeki 
World J Transl Med 4(3):113-122. Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.113
14
Cognitive, behavioural and psychiatric phenotypes associated with steroid sulfatase deficiency  
Simon Trent, William Davies 
World J Transl Med 2(1):1-12. Published online Apr 12, 2013. doi: 10.5528/wjtm.v2.i1.1
15
Contributions of neutrophils to the adaptive immune response in autoimmune disease  
Kathryn M Pietrosimone, Peng Liu 
World J Transl Med 4(3):60-68. Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.60
16
Prednisolone inhibits SaOS2 osteosarcoma cell proliferation by activating inducible nitric oxide synthase  
Alessandra Cazzaniga, Jeanette A M Maier, Sara Castiglioni 
World J Transl Med 5(1):53-58. Published online Apr 12, 2016. doi: 10.5528/wjtm.v5.i1.53
17
Beyond the bedside: A review of translational medicine in global health  
Richard S Hoehn, Daniel E Abbott 
World J Transl Med 4(1):1-10. Published online Apr 12, 2015. doi: 10.5528/wjtm.v4.i1.1
18
Nanotechnological approaches in diabetes treatment: A new horizon  
Asmita Samadder, Anisur Rahman Khuda-Bukhsh 
World J Transl Med 3(2):84-95. Published online Aug 12, 2014. doi: 10.5528/wjtm.v3.i2.84
19
Therapeutic targets in gastrointestinal stromal tumors  
Jia-Qing Zhu, Wen-Bin Ou 
World J Transl Med 4(1):25-37. Published online Apr 12, 2015. doi: 10.5528/wjtm.v4.i1.25
20
Translating laboratory anti-aging biotechnology into applied clinical practice: Problems and obstacles  
Marios Kyriazis 
World J Transl Med 4(2):51-54. Published online Aug 12, 2015. doi: 10.5528/wjtm.v4.i2.51
21
Liver transplantation with grafts obtained after cardiac death-current advances in mastering the challenge  
Fateh Bazerbachi, Nazia Selzner, John B Seal, Markus Selzner 
World J Transl Med 3(2):58-68. Published online Aug 12, 2014. doi: 10.5528/wjtm.v3.i2.58
22
Modern advances in reducing anxiety and pain associated with cystoscopy: Systematic review  
Hossein S Mirheydar, Omer A Raheem, Fuad F Elkhoury, Ramzi Jabaji, Kerrin L Palazzi, Nishant Patel, Rogelio Du, Scott Maroney, Kyoko Sakamoto 
World J Transl Med 4(1):38-43. Published online Apr 12, 2015. doi: 10.5528/wjtm.v4.i1.38
23
Psychotherapy in anorexia nervosa: What does the absence of evidence mean?  
Emilio Gutiérrez, Olaia Carrera 
World J Transl Med 3(3):150-157. Published online Dec 12, 2014. doi: 10.5528/wjtm.v3.i3.150
24
Naked DNA in cells: An inducer of major histocompatibility complex molecules to evoke autoimmune responses?  
Yuqian Luo, Aya Yoshihara, Kenzaburo Oda, Yuko Ishido, Naoki Hiroi, Koichi Suzuki 
World J Transl Med 5(1):46-52. Published online Apr 12, 2016. doi: 10.5528/wjtm.v5.i1.46
25
p38 mitogen-activated protein kinase regulates type-I vs type-II phenotyping of human vascular endothelial cells  
Masako Nakahara, Miwako Nishio, Koichi Saeki, Akira Yuo, Kumiko Saeki 
World J Transl Med 4(3):101-112. Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.101
26
Targeting apoptosis is the major battle field for killing cancers  
Xiao-Chun Liu, Jiang-Ming Gao, Shan Liu, Li Liu, Jing-Rui Wang, Xian-Jun Qu, Bing Cai, Shu-Lin Wang 
World J Transl Med 4(3):69-77. Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.69
27
Potential therapeutic targets from genetic and epigenetic approaches for asthma  
Youming Zhang 
World J Transl Med 5(1):14-25. Published online Apr 12, 2016. doi: 10.5528/wjtm.v5.i1.14
28
Nutritional determinants of anemia among adults in Eastern China  
Zumin Shi, Anne W Taylor 
World J Transl Med 4(2):55-59. Published online Aug 12, 2015. doi: 10.5528/wjtm.v4.i2.55
29
Sphingolipid metabolism affects the anticancer effect of cisplatin  
Yu-Lan Li, Ming-Lin Lin, Song-Qing He, Jun-Fei Jin 
World J Transl Med 5(1):37-45. Published online Apr 12, 2016. doi: 10.5528/wjtm.v5.i1.37
30
“Diabegon”, a safe and effective polyherbal therapy for type 2 diabetes mellitus  
Sunil Mahajan, Nita Singh, Senthil K Subramanian, Pratibha Chauhan, Sonali Saxena, HM Goswamy, GBKS Prasad, Prakash S Bisen 
World J Transl Med 2(3):75-82. Published online Dec 12, 2013. doi: 10.5528/wjtm.v2.i3.75
31
Role of nestin in glioma invasion  
Alex Lin, Luigi Marchionni, Jeffrey Sosnowski, David Berman, Charles G Eberhart, Eli E Bar 
World J Transl Med 4(3):78-87. Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.78
32
High-potency sucralfate prevents and rapidly reverses chemo-radiation mucositis in a patient with stage 4b head and neck cancer  
Ricky W McCullough 
World J Transl Med 2(2):13-21. Published online Aug 12, 2013. doi: 10.5528/wjtm.v2.i2.13
33
Physics and mathematics of magnetic resonance imaging for nanomedicine: An overview  
Odey Samuel Onwu, Oluwaseun Michael Dada, Omotayo Bamidele Awojoyogbe 
World J Transl Med 3(1):17-30. Published online Apr 12, 2014. doi: 10.5528/wjtm.v3.i1.17
34
Impact of viral and bacterial infections in coronary artery disease patients  
Hem Chandra Jha, Aruna Mittal 
World J Transl Med 2(3):49-55. Published online Dec 12, 2013. doi: 10.5528/wjtm.v2.i3.49
35
Translational medical mycology guides clinical and laboratory practice on fungal diseases  
Jebina Lama, Xin Ran, Yu-Ping Ran 
World J Transl Med 3(1):31-36. Published online Apr 12, 2014. doi: 10.5528/wjtm.v3.i1.31
36
Epithelial ovarian cancer: An overview  
Arpita Desai, Jingyao Xu, Kartik Aysola, Yunlong Qin, Chika Okoli, Ravipati Hariprasad, Ugorji Chinemerem, Candace Gates, Avinash Reddy, Omar Danner, Geary Franklin, Anachebe Ngozi, Guilherme Cantuaria, Karan Singh, William Grizzle, Charles Landen, Edward E Partridge, Valerie Montgomery Rice, E Shyam P Reddy, Veena N Rao 
World J Transl Med 3(1):1-8. Published online Apr 12, 2014. doi: 10.5528/wjtm.v3.i1.1
37
Pathophysiological responses from human gut microbiome  
Anindya Roy Chowdhury, Utpal Bakshi 
World J Transl Med 3(3):133-140. Published online Dec 12, 2014. doi: 10.5528/wjtm.v3.i3.133
38
Hypo-activity induced skeletal muscle atrophy and potential nutritional interventions: A review  
Emma L Bostock, Christopher I Morse, Keith Winwood, Islay McEwan, Gladys L Onambélé-Pearson 
World J Transl Med 2(3):36-48. Published online Dec 12, 2013. doi: 10.5528/wjtm.v2.i3.36
39
Molecular recognition of live methicillin-resistant staphylococcus aureus cells using DNA aptamers  
Diane Turek, Dimitri Van Simaeys, Judith Johnson, Ismail Ocsoy, Weihong Tan 
World J Transl Med 2(3):67-74. Published online Dec 12, 2013. doi: 10.5528/wjtm.v2.i3.67
40
Component-resolved allergen testing: The new frontier  
Matthew T Tallar, Mitchell H Grayson 
World J Transl Med 4(2):44-50. Published online Aug 12, 2015. doi: 10.5528/wjtm.v4.i2.44
41
Examining the relationship between physical fitness and spiritual fitness in cancer patients: A pilot study  
Karen Y Wonders, Hallie Loy, Brian Holt, Kelsey Bohachek, Robert Wise 
World J Transl Med 2(2):22-26. Published online Aug 12, 2013. doi: 10.5528/wjtm.v2.i2.22
42
Effects of USPSTF guidelines on patterns of screening and treatment outcomes for prostate cancer  
Vindya Gunawardena, Jeanny B Aragon-Ching 
World J Transl Med 3(2):112-118. Published online Aug 12, 2014. doi: 10.5528/wjtm.v3.i2.112
43
Recent advances and perspectives on tropical diseases: Malaria  
Nicola Micale 
World J Transl Med 1(2):4-19. Published online Aug 12, 2012. doi: 10.5528/wjtm.v1.i2.4
44
More than boric acid: Increasing relevance of boron in medicine  
Eunice D Farfán-García, Emily L Castillo-García, Marvin A Soriano-Ursúa 
World J Transl Med 7(1):1-4. Published online Sep 20, 2018. doi: 10.5528/wjtm.v7.i1.1
45
Inflammation and cardiovascular disease  
Christina G Katsiari, Dimitrios P Bogdanos, Lazaros I Sakkas 
World J Transl Med 8(1):1-8. Published online Jan 31, 2019. doi: 10.5528/wjtm.v8.i1.1
46
Peptide-based boronates: How to achieve tissue specificity in anticancer therapy  
Nicola Micale 
World J Transl Med 2(3):32-35. Published online Dec 12, 2013. doi: 10.5528/wjtm.v2.i3.32
47
Evaluation of three methods for detection of methicillin-resistant Staphylococcus aureus  
Asli Gamze Sener, Sevin Kirdar, Ilhan Afsar, Mustafa Demirci 
World J Transl Med 2(2):27-31. Published online Aug 12, 2013. doi: 10.5528/wjtm.v2.i2.27
48
What is the purpose of launching the World Journal of Translational Medicine?  
Alfonso Dueñas-González 
World J Transl Med 1(1):1-3. Published online Jun 12, 2012. doi: 10.5528/wjtm.v1.i1.1