Published online Jan 31, 2019. doi: 10.5528/wjtm.v8.i1.1
Peer-review started: August 6, 2018
First decision: October 10, 2018
Revised: January 9, 2019
Accepted: January 28, 2019
Article in press: January 28, 2019
Published online: January 31, 2019
Core tip: The association of inflammation with cardiovascular disease (CVD) has two aspects. The first is whether inflammation plays a pathogenic role in traditional risk factors-mediated CVD or it is just an epiphenomenon. The second is whether chronic inflammation caused by an inflammatory disease has any impact on CVD. Chronic inflammation exemplified by elevated high sensitivity C-reactive protein has been added for risk factors for CVD. How inflammation contributes to CVD is a topic of continuous research. A trial showing that anti-IL1b monoclonal-antibody reduced cardiovascular events is the best proof of the pathogenic contribution of inflammation in atherosclerosis and CVD.