Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transl Med. Aug 26, 2022; 10(3): 29-42
Published online Aug 26, 2022. doi: 10.5528/wjtm.v10.i3.29
Photobiomodulation therapy for osteoarthritis: Mechanisms of action
Fábio Pericinoto Giolo, Gabriel Silva Santos, Victor Fontes Pacheco, Stephany Cares Huber, Kaue Franco Malange, Bruno Lima Rodrigues, Fernanda Bassora, Tomas Mosaner, Gabriel Azzini, Lucas Leite Ribeiro, Carlos Amilcar Parada, José Fábio Santos Duarte Lana
Fábio Pericinoto Giolo, Department of Physical Therapy, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil
Gabriel Silva Santos, Stephany Cares Huber, Bruno Lima Rodrigues, Biomedical Science, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil
Victor Fontes Pacheco, Tomas Mosaner, Gabriel Azzini, Lucas Leite Ribeiro, José Fábio Santos Duarte Lana, Department of Orthopedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil
Kaue Franco Malange, Carlos Amilcar Parada, Neurobiology of Pain and Regenerative Medicine, The University of Campinas, Campinas 13083-862, Brazil
Fernanda Bassora, Department of Hematology, The University of Campinas, Campinas 13083-878, Brazil
Author contributions: Santos GS and Giolo FP wrote the manuscript; Pacheco VF and Huber SC proposed the research subtopics; Rodrigues BL, Malange KF and Bassora F were responsible for navigating the literature and sharing the relevant studies included in this review. Mosaner T formatted the citations and compiled the references; Parada CA revised and formatted the body of the manuscript, correcting spelling, punctuation and grammatical errors. Azzini G and Ribeiro LL created the figures and tables. As the leader, Lana JFSD was responsible for reviewing and approving all the modifications made to the manuscript, from draft to final version.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Gabriel Silva Santos, BSc, Academic Research, Instructor, Lecturer, Research Scientist, Technician, Biomedical Science, Brazilian Institute of Regenerative Medicine, 1386 Presidente Kennedy Avenue, Indaiatuba 13334-170, Brazil.
Received: March 24, 2022
Peer-review started: March 24, 2022
First decision: May 12, 2022
Revised: May 23, 2022
Accepted: August 6, 2022
Article in press: August 6, 2022
Published online: August 26, 2022
Core Tip

Core Tip: Photobiomodulation (PBM) is a non-invasive therapeutic modality with demonstrated effects in regenerative medicine. In the field of orthopedics, in particular, PBM at various wavelengths has demonstrated the capacity to trigger multiple biological effects associated with protective mechanisms in musculoskeletal tissues. These responses include proliferation, differentiation and expression of proteins associated with stable cell cycles. Additionally, PBM can also modulate oxidative stress, inflammation and pain by exerting regulatory effects on immune cells and blocking the transmission of pain through sensory neuron fibers.