Review
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World J Transl Med. Dec 12, 2014; 3(3): 133-140
Published online Dec 12, 2014. doi: 10.5528/wjtm.v3.i3.133
Pathophysiological responses from human gut microbiome
Anindya Roy Chowdhury, Utpal Bakshi
Anindya Roy Chowdhury, Utpal Bakshi, Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India
Author contributions: Roy Chowdhury A designed the study, wrote the manuscript; Bakshi U contributed to the writing of the manuscript.
Supported by University Grants Commission (India) (Bakshi U)
Correspondence to: Dr. Anindya Roy Chowdhury, Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata 700032, India. ani.rc.29@gmail.com
Telephone: +91-33-24995875 Fax: +91-33-24735197
Received: June 16, 2014
Revised: August 21, 2014
Accepted: September 18, 2014
Published online: December 12, 2014
Processing time: 179 Days and 21 Hours
Abstract

The human gastrointestinal tract harbors a vast collection of symbiotic microorganisms-collectively termed as “gut microbiome”. This microbiota has important effect in immune system and other host activities. Recent studies have suggested that alterations of the normal gut microbiota are associated with various human diseases and psychological disorders. The underlying cause, once proven, may provide novel insights into the importance of gut flora in human health. In this review, we give an attempt to describe how the alteration in the microbial community causes the development of certain widespread pathophysiological disorders; focusing on inflammatory bowel disease, colorectal cancer, obesity and autism. Proper knowledge about the host-microbiota interaction and linkage could be essential for the development of future personalized strategies of therapeutics.

Keywords: Human gut microbiome; Inflammatory bowel disease; Colorectal cancer; Obesity; Autism

Core tip: This review is an endeavor to provide an account about the human gut microbiome, their diversity, and disease causing capability. Till date, so many diseases have been associated with the alteration of gut microbiota. In this review we talk about four of the major diseases/disorders, viz., inflammatory bowel disease, colorectal cancer, obesity and autism.