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Topic Highlight
Fibroblasts, an inconspicuous but essential player in colon cancer development and progression 
Naofumi Mukaida, Soichiro Sasaki 
World J Gastroenterol 22(23):5301-5316. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5301
MicroRNAs: Novel immunotherapeutic targets in colorectal carcinoma 
Xiang Li, Jing Nie, Qian Mei, Wei-Dong Han 
World J Gastroenterol 22(23):5317-5331. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5317
Treatment dilemmas of cetuximab combined with chemotherapy for metastatic colorectal cancer 
Feng Wen, Qiu Li 
World J Gastroenterol 22(23):5332-5341. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5332
Basic Study
Tumor-specific expression of shVEGF and suicide gene as a novel strategy for esophageal cancer therapy 
Ting Liu, Hai-Jun Wu, Yu Liang, Xu-Jun Liang, Hui-Chao Huang, Yan-Zhong Zhao, Qing-Chuan Liao, Ya-Qi Chen, Ai-Min Leng, Wei-Jian Yuan, Gui-Ying Zhang, Jie Peng, Yong-Heng Chen 
World J Gastroenterol 22(23):5342-5352. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5342
Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway 
Hai Li, Yan Chen, Shi Liu, Xiao-Hua Hou 
World J Gastroenterol 22(23):5353-5363. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5353
MicroRNA-548a-5p promotes proliferation and inhibits apoptosis in hepatocellular carcinoma cells by targeting Tg737 
Ge Zhao, Ting Wang, Qi-Ke Huang, Meng Pu, Wei Sun, Zhuo-Chao Zhang, Rui Ling, Kai-Shan Tao 
World J Gastroenterol 22(23):5364-5373. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5364
Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice 
Hai-Mei Zhao, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Ai-Ping Lu, Duan-Yong Liu 
World J Gastroenterol 22(23):5374-5383. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5374
Case Control Study
Adjuvant sorafenib after heptectomy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma patients 
Feng Xia, Li-Li Wu, Wan-Yee Lau, Hong-Bo Huan, Xu-Dong Wen, Kuan-Sheng Ma, Xiao-Wu Li, Ping Bie 
World J Gastroenterol 22(23):5384-5392. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5384
Retrospective Cohort Study
Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma 
Danbi Lee, Heather Lyu, Young-Hwa Chung, Jeong A Kim, Priya Mathews, Elizabeth Jaffee, Lei Zheng, Eunsil Yu, Young Joo Lee, Soo Hyung Ryu 
World J Gastroenterol 22(23):5393-5399. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5393
Retrospective Study
Last line therapy with sorafenib in colorectal cancer: A retrospective analysis 
Ksenia Martchenko, Irene Schmidtmann, Thomas Thomaidis, Verena Thole, Peter R Galle, Marc Becker, Markus Möhler, Thomas C Wehler, Carl C Schimanski 
World J Gastroenterol 22(23):5400-5405. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5400
Association of HER2 status with prognosis in gastric cancer patients undergoing R0 resection: A large-scale multicenter study in China 
Guo-Shuang Shen, Jiu-Da Zhao, Jun-Hui Zhao, Xin-Fu Ma, Feng Du, Jie Kan, Fa-Xiang Ji, Fei Ma, Fang-Chao Zheng, Zi-Yi Wang, Bing-He Xu 
World J Gastroenterol 22(23):5406-5414. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5406
Clinical Trials Study
Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917 
Elina Manzhalii, Daniel Hornuss, Wolfgang Stremmel 
World J Gastroenterol 22(23):5415-5421. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5415
Observational Study
Endocan-expressing microvessel density as a prognostic factor for survival in human gastric cancer 
Yuan Chang, Wei Niu, Pei-Long Lian, Xian-Qiang Wang, Zhi-Xin Meng, Yi Liu, Rui Zhao 
World J Gastroenterol 22(23):5422-5429. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5422
Randomized Clinical Trial
Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease 
Ryuta Takenaka, Hiroyuki Okada, Seiji Kawano, Yoshinori Komazawa, Fumiya Yoshinaga, Shinji Nagata, Masafumi Inoue, Hirohisa Komatsu, Seiji Onogawa, Yoshinori Kushiyama, Shinichi Mukai, Hiroko Todo, Hideharu Okanobu, Noriaki Manabe, Shinji Tanaka, Ken Haruma, Yoshikazu Kinoshita 
World J Gastroenterol 22(23):5430-5435. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5430
Meta-Analysis
Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis 
Mikihiro Fujiya, Hiroki Sato, Nobuhiro Ueno, Aki Sakatani, Kazuyuki Tanaka, Tatsuya Dokoshi, Shugo Fujibayashi, Yoshiki Nomura, Shin Kashima, Takuma Gotoh, Junpei Sasajima, Kentaro Moriichi, Jiro Watari, Yutaka Kohgo 
World J Gastroenterol 22(23):5436-5444. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5436
Nonbismuth concomitant quadruple therapy for Helicobacter pylori eradication in Chinese regions: A meta-analysis of randomized controlled trials 
Lien-Chieh Lin, Tzu-Herng Hsu, Kuang-Wei Huang, Ka-Wai Tam 
World J Gastroenterol 22(23):5445-5453. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5445
Case Report
Endoscopic en bloc resection of an exophytic gastrointestinal stromal tumor with suction excavation technique 
Hyuk Soon Choi, Hoon Jai Chun, Kyoung-Oh Kim, Eun Sun Kim, Bora Keum, Yoon-Tae Jeen, Hong Sik Lee, Chang Duck Kim 
World J Gastroenterol 22(23):5454-5458. Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5454