Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis

Table 1 Quality assessment of bias in included studies

Ref.	Risk of bias						Jadad score
	Adequacy of random sequence generation	Allocation concealment	Blinding of the participants, personnel and outcome assessors	Blind outcome assessment	Incomplete outcome data	Selective outcome reporting	Details of randomization	Blinding procedures	Information regarding withdrawals	Total score
Horiuchi et al[15], 2010	High	High	Unclear	Unclear	Unclear	Low	1	1	0	2
Ichise et al[16], 2011	Unclear	Low	Unclear	Unclear	Unclear	Low	2	1	0	3
Paspatis et al[17], 2011	Low	Unclear	Unclear	Unclear	Unclear	Low	2	0	1	3
Aslan et al[18], 2013	High	High	Unclear	Unclear	High	Unclear	1	1	0	2
Horiuchi et al[21], 2013	Low	Low	Unclear	Unclear	Unclear	Unclear	2	2	0	4
Gomez et al[20], 2014	Low	Low	Unclear	Unclear	Low	Unclear	2	1	1	3

Table 2 Details of included studies

Ref.	Patient, Age, mean ± SD or median (range)	Gender (M/F)	No. of polyps	Tumor size, mean ± SD (mm)	Endoscopic procedure for cold polypectomy	No. of all adverse events	Macroscopic appearances		Histologicalfindings			Complete retrieval rate	Post-polypectomy bleeding	Procedure time, mean ± SD (min)
							0-I	0-II	High grade adenoma	Low grade adenoma	Hyperplastic polyp
Cold polypectomy
Horiuchi et al[15], 2010	NA	NA	94	NA	Snare	1	NA	NA	NA	NA	NA	96	0	18
Ichise et al[16], 2011	65.1 ± 11	25/15	101	5.7 ± 4	Snare	1	89	12	1	94	6	96	0	18 ± 6
Paspatis et al[17], 2011	59.4 ± 13.6	107/101	636	5.3 ± 1.4	Snare	19	NA	NA	NA	NA	NA	96	0	23.3 ± 4.8
Aslan et al[18], 2013	59.5 ± 14.9	32/17	78	7.21 ± 1.4	Snare	1	NA	NA	NA	NA	NA	94.9	1	NA
Horiuchi et al[21], 2013	67.0 ± 13	25/10	78	6.5 ± 1.2	Snare	4	55	23	2	70	6	94	0	16 ± 7
Gomez et al[20], 2014	NA	NA	44	NA	Snare or Forceps	0	NA	NA	NA	NA	NA	90 (cold snare), 89 (cold forceps)	0	NA
Hot polypectomy
Horiuchi et al[15], 2010	NA	NA	92	NA	-	8	NA	NA	NA	NA	NA	97	0	25
Ichise et al[16], 2011	65.5 ± 12	28/12	104	5.5 ± 6	-	8	95	9	1	93	10	96	0	25 ± 7
Paspatis et al[17], 2011	61.3 ± 11	125/81	619	5.67 ± 1.3	-	2	NA	NA	NA	NA	NA	96	0	29.6 ± 7.4
Aslan et al[18], 2013	58.3 ± 13.5	36/12	71	7.56 ± 1.45	-	1	NA	NA	NA	NA	NA	94.4	1	NA
Horiuchi et al[21], 2013	67.3 ± 12	24/11	81	6.8 ± 1.3	-	16	62	19	2	72	7	93	5	26 ± 9
Gomez et al[20], 2014	NA	NA	18	NA	-	0	NA	NA	NA	NA	NA	94	0	NA

NA: Data not available.