Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917

Table 1 Baseline characteristics of the study population

Characteristic	Experimental	Control
	arm (n = 37)	arm (n = 20)
Sex (women)	63%	61%
Sex (male)	37%	39%
Age (yr)	29 ± 3.1	28 ± 2.5
Smoker	34%	36%
Oral contraception (women)	4%	5%

Table 2 Interferon-α, interleukin-8 and IgA in serum before and after treatment

	INF-α, pg/mL		IL-8, pg/mL		IgA, g/L
Arms of the patients	Before	After	Before	After	Before	After
	treatment	treatment	treatment	treatment	treatment	treatment
Experimental	8.07 ± 2.97	3.73 ± 2.88df	30.8 ± 4.42	17.1 ± 0.65df	0.45 ± 0.05b	0.71±0.22df
arm (n = 37)
Control	6.88 ± 1.77	6.12 ± 1.53	27.0 ± 2.72	25.2 ± 1.23b	0.35 ± 0.9	0.54 ±0.05d
arm (n = 20)

^bP < 0.01 and

^dP < 0.001 significant difference before vs after treatment;

^fP < 0.01 vs control arm after treatment. INF: Interferon; IL: Interleukin.

Table 3 Changes of the flora after treatment with E. coli Nissle n (%)

	Experimental		Control
	arm (n = 37)		arm (n = 20)
Microflora	Before	After	Before	After
characteristics	treatment	treatment	treatment	treatment
Bifidobacteria
> 107 CFU/g	5 (14)	29 (79)b	3 (15)	3 (15)
Normal
< 107 CFU/g	26 (70)	7 (19)b	15 (75)	14 (70)
Below normal
absent	6 (16)	1 (2)b	2 (10)	3 (15)
Lactobacteria
> 107 CFU/g	3 (8)	23 (63)b	3 (15)	2 (10)
Normal
< 107 CFU/g	27 (73)	13 (35)b	15 (75)	15 (75)
Below normal
absent	7 (19)	1 ( 2)b	2 (10)	3 (15)
Pathogenic
microflora	27 (73)	5 (14)b	16 (80)	14 (70)

^bP < 0.01 significant difference before vs after treatment.