Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease

Figure 1 Patient flow.

Figure 2 Frequency of heartburn evaluated using patient’ questionnaires. Data are shown as a boxplot. In both groups, the frequency of heartburn was reduced after initial treatment, ^bP < 0.01.

Figure 3 Change in heartburn frequency after initial treatment. Data are shown as a boxplot. There were no significant difference between the lafutidine group and the lansoprazole group (P = 0.26).

Figure 4 Severity of heartburn evaluated using visual analog scale scores. Data are expressed as means ± SE. VAS scores in the lafutidine group were significantly worse than in the lansoprazole group (P = 0.016, ANOVA for repeated measures). VAS: Visual analog scale.

Figure 5 Sum score of question 2 and question 3 in the GSRS score. Data are expressed as means ± SE. VAS scores in the lafutidine group were significantly worse than in the lansoprazole group (P = 0.0068, ANOVA for repeated measures). VAS: Visual analog scale.

Figure 6 Satisfaction score evaluated using visual analog scale scores. Data are expressed as means ± SE. VAS scores in the lafutidine group were significantly worse than the lansoprazole group (P = 0.0048, ANOVA for repeated measures). VAS: Visual analog scale.