Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway
Hai Li, Yan Chen, Shi Liu, Xiao-Hua Hou, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Liu S conceived and designed the experiments; Li H and Chen Y performed the experiments; Li H analyzed the data; Liu S and Hou XH contributed reagents/materials/analytical tools; Li H wrote the paper; and Hou XH is the main controller of the laboratory.
Supported by National Natural Science Foundation of China, No. 81270458 and No. 81570488.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
Institutional animal care and use committee statement: All experiments involving animals were reviewed and approved by the Animal Care and Use Committee of Tongji Medical College, Huazhong University of Science and Technology (IACUC No. 488).
Conflict-of-interest statement: We declare that the authors of this article do not have any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shi Liu, MD, Professor, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. email@example.com
Telephone: +86-27-85726381 Fax: +86-27-85726930
Received: March 1, 2016
Peer-review started: March 3, 2016
First decision: April 1, 2016
Revised: April 14, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: June 21, 2016