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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2016; 22(23): 5317-5331
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5317
MicroRNAs: Novel immunotherapeutic targets in colorectal carcinoma
Xiang Li, Jing Nie, Qian Mei, Wei-Dong Han
Xiang Li, Jing Nie, Qian Mei, Wei-Dong Han, Department of Molecular Biology, School of Life Sciences, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Li X searched the literature and contributed largely to the writing of the manuscript; Nie J contributed with her own opinions to this review and offered suggestions on the structure of this paper; Mei Q and Han WD contributed to the writing, reviewed all the versions of the manuscript, gave the final approval of the version to be published and revised this article for important intellectual content; Mei Q and Han WD are co-corresponding authors.
Supported by National Natural Science Foundation of China, No. 81272867 and No. 81572914; Beijing Nova Program, No. Z131107000413103.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Wei-Dong Han, PhD, MD, Professor, Department of Molecular Biology, School of Life Sciences, Chinese PLA General Hospital, Beijing 100853, China.
Telephone: +86-10-66937463 Fax: +86-10-66937516
Received: March 24, 2016
Peer-review started: March 25, 2016
First decision: April 14, 2016
Revised: April 23, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: June 21, 2016
Core Tip

Core tip: Colorectal carcinoma (CRC) is one of the most common tumor types worldwide. Immunotherapy has been used to treat advanced CRC and has the potential to eradicate the disease by activating immune responses. MicroRNAs play critical roles in regulating anti-tumor immune responses. There is a need to summarize the current understanding of the diverse roles of microRNAs in the regulation of immune responses and their clinical applications for CRC immunotherapy.