Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5332
Peer-review started: March 22, 2016
First decision: April 14, 2016
Revised: May 2, 2016
Accepted: May 21, 2016
Article in press: May 23, 2016
Published online: June 21, 2016
Core tip: The advent of epidermal growth factor receptor monoclonal antibodies (EGFR mAbs), especially cetuximab, has provided a meaningful transformation in the available treatment options for advanced colorectal cancer (CRC). Nevertheless, their efficacy is accompanied by some undesired complications. Additionally, combination treatments comprising EGFR mAbs and traditional cytotoxic agents have resulted in a more complex management of CRC treatment-related side effects. Therefore, it is imperative to understand and appropriately address the treatment dilemmas of cetuximab combined with chemotherapy for the management of metastatic CRC.