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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Role of mitogen- and stress-activated kinases in inflammatory arthritis  
Sylvain G Bourgoin, Weili Hui 
World J Pharmacol 4(4):265-273. Published online Dec 9, 2015. doi: 10.5497/wjp.v4.i4.265
2
Ocular drug delivery systems: An overview  
Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra 
World J Pharmacol 2(2):47-64. Published online Jun 9, 2013. doi: 10.5497/wjp.v2.i2.47
3
Therapeutic targets and delivery challenges for Alzheimer’s disease  
Preshita Desai, Harshad Shete, Rahul Adnaik, John Disouza, Vandana Patravale 
World J Pharmacol 4(3):236-264. Published online Sep 9, 2015. doi: 10.5497/wjp.v4.i3.236
4
Non-selective beta-blockers in cirrhosis: Current concepts and controversies  
Neil Rajoriya, Dhiraj Tripathi 
World J Pharmacol 5(1):15-31. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.15
5
Drug delivery in ocular diseases: Barriers and strategies  
Deep Kwatra, Ashim K Mitra 
World J Pharmacol 2(4):78-83. Published online Dec 9, 2013. doi: 10.5497/wjp.v2.i4.78
6
Updates on therapies for chronic prostatitis/chronic pelvic pain syndrome  
Asfandyar Khan, Adam B Murphy 
World J Pharmacol 4(1):1-16. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.1
7
Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement  
María L Cuestas, José R Oubiña, Verónica L Mathet 
World J Pharmacol 4(1):96-116. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.96
8
Role of opioid receptor heterodimerization in pain modulation and tolerance development  
Annu Mudgal, Santosh Pasha 
World J Pharmacol 4(1):144-159. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.144
9
Targeted approaches for HER2 breast cancer therapy: News from nanomedicine?  
Serena Mazzucchelli, Marta Truffi, Luisa Fiandra, Luca Sorrentino, Fabio Corsi 
World J Pharmacol 3(4):72-85. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.72
10
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?  
Pamela J Weathers, Melissa Towler, Ahmed Hassanali, Pierre Lutgen, Patrick Ogwang Engeu 
World J Pharmacol 3(4):39-55. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.39
11
Drug-transporter interaction testing in drug discovery and development  
Peter Krajcsi 
World J Pharmacol 2(1):35-46. Published online Mar 9, 2013. doi: 10.5497/wjp.v2.i1.35
12
Carbapenemases: A worldwide threat to antimicrobial therapy  
José Miguel Sahuquillo-Arce, Alicia Hernández-Cabezas, Fernanda Yarad-Auad, Elisa Ibáñez-Martínez, Patricia Falomir-Salcedo, Alba Ruiz-Gaitán 
World J Pharmacol 4(1):75-95. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.75
13
Novel strategies for the treatment of diabetic macular edema  
Hoang M Trinh, Mary Joseph, Kishore Cholkar, Dhananjay Pal, Ashim K Mitra 
World J Pharmacol 5(1):1-14. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.1
14
Phosphoprotein phosphatase 1-interacting proteins as therapeutic targets in prostate cancer  
Juliana Felgueiras, Margarida Fardilha 
World J Pharmacol 3(4):120-139. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.120
15
Asthma in pregnancy  
Hayley K Blackburn, Douglas R Allington, Kendra A Procacci, Michael P Rivey 
World J Pharmacol 3(4):56-71. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.56
16
Appropriate prescribing in the elderly: Current perspectives  
Amanda Hanora Lavan, John O’Grady, Paul Francis Gallagher 
World J Pharmacol 4(2):193-209. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.193
17
Implantable (Bio)sensors as new tools for wireless monitoring of brain neurochemistry in real time  
Donatella Farina, Maria D Alvau, Giulia Puggioni, Giammario Calia, Gianfranco Bazzu, Rossana Migheli, Ottavio Sechi, Gaia Rocchitta, Maria S Desole, Pier Andrea Serra 
World J Pharmacol 3(1):1-17. Published online Mar 9, 2014. doi: 10.5497/wjp.v3.i1.1
18
Pharmacophore approaches in protein kinase inhibitors design  
Sergiy A Starosyla, Galyna P Volynets, Volodymyr G Bdzhola, Andriy G Golub, Sergiy M Yarmoluk 
World J Pharmacol 3(4):162-173. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.162
19
Drug therapy for Parkinson’s disease: An update  
Omar ME Abdel-Salam 
World J Pharmacol 4(1):117-143. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.117
20
Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia  
Shaun Hopper, Madhara Udawela, Elizabeth Scarr, Brian Dean 
World J Pharmacol 5(1):32-43. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.32
21
Overview on metabolomics in traditional Chinese medicine  
Shi Qiu, Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Xi-Jun Wang 
World J Pharmacol 3(3):33-38. Published online Sep 9, 2014. doi: 10.5497/wjp.v3.i3.33
22
23
Pharmacological management of neuropathic pain in patients with vestibular schwannomas: Experience of the Atlantic Lateral Skull Base Clinic  
Andrea LO Hebb, Jana Sawynok, Manohar Bance, Simon Walling, Ken Chisholm, David P Morris 
World J Pharmacol 3(2):24-32. Published online Jun 9, 2014. doi: 10.5497/wjp.v3.i2.24
24
Chemoprevention of gastrointestinal cancers by natural honey  
Mohamed MM Abdel-Latif 
World J Pharmacol 4(1):160-167. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.160
25
Tenofovir induced severe thrombocytopenia  
Mayank Jain, Joy Vargese, Jayanthi Venkatatraman 
World J Pharmacology 6(2):11-13. Published online Jun 9, 2017. doi: 10.5497/wjp.v6.i2.11
26
Adalimumab and pharmacokinetics: Impact on the clinical prescription for inflammatory bowel disease  
Anne-Laure Pelletier, Pascale Nicaise-Roland 
World J Pharmacol 5(1):44-50. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.44
27
Improving cancer therapy by targeting cancer stem cells: Directions, challenges, and clinical results  
Pier Adelchi Ruffini, Valentina Vaja, Marcello Allegretti 
World J Pharmacol 4(1):58-74. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.58
28
Innovate combination of sevoflurane dilution in dimethyl sulfoxide: A stability study by gas chromatography and nuclear magnetic resonance  
F Dámaso Fernández-Ginés, Sergio García-Muñoz, Héctor Mateo-Carrasco, Miguel Ángel Rincón-Cervera, Manuel Cortiñas-Sáenz, José Antonio Morales-Molina, Carmen Fernández-Sánchez, Juan Miguel Expósito-López, Ignacio Rodríguez-García 
World J Pharmacology 5(3):59-67. Published online Sep 9, 2016. doi: 10.5497/wjp.v5.i3.59
29
Aryl hydrocarbon receptor as a new therapeutic target for cancer and immune disorders  
Libia Vega, Guillermo Elizondo 
World J Pharmacol 2(4):107-114. Published online Dec 9, 2013. doi: 10.5497/wjp.v2.i4.107
30
Antimicrobial resistance in clinically important biofilms  
Fatemeh Rafii, Mark E Hart 
World J Pharmacol 4(1):31-46. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.31
31
Progress in pancreatic cancer therapeutics: The potential to exploit molecular targets  
Kiruthikah Thillai, Debashis Sarker, Paul Ross 
World J Pharmacol 4(2):180-192. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.180
32
Potential ability of xanthophylls to prevent obesity-associated cancer  
Masaru Terasaki, Michihiro Mutoh, Gen Fujii, Mami Takahashi, Rikako Ishigamori, Sonoko Masuda 
World J Pharmacol 3(4):140-152. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.140
33
Importance of microenvironment in preclinical models of breast and prostate cancer  
Maija Valta, Katja Fagerlund, Mari Suominen, Jussi Halleen, Johanna Tuomela 
World J Pharmacol 4(1):47-57. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.47
34
Utility of transporter/receptor(s) in drug delivery to the eye  
Sai HS Boddu, Jerry Nesamony 
World J Pharmacol 2(1):1-17. Published online Mar 9, 2013. doi: 10.5497/wjp.v2.i1.1
35
36
Long-term potentiation in autonomic ganglia: Potential role in cardiovascular disorders  
Karim A Alkadhi 
World J Pharmacol 5(2):51-58. Published online Jun 9, 2016. doi: 10.5497/wjp.v5.i2.51
37
Arsenic exposure decreases rhythmic contractions of vascular tone through sodium transporters and K+ channels  
Javier Palacios, Chukwuemeka R Nwokocha, Fredi Cifuentes 
World J Pharmacol 3(2):18-23. Published online Jun 9, 2014. doi: 10.5497/wjp.v3.i2.18
38
Levomilnacipran and vortioxetine: Review of new pharmacotherapies for major depressive disorder  
Mei T Liu, Megan E Maroney, Evelyn R Hermes-DeSantis 
World J Pharmacol 4(1):17-30. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.17
39
Association of serum bilirubin and non-alcoholic fatty liver disease: A feasible therapeutic avenue?  
Mohamed S Anwar, John F Dillon, Michael H Miller 
World J Pharmacol 3(4):209-216. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.209
40
How and why chemicals from tobacco smoke can induce a rise in blood pressure  
Aurelio Leone 
World J Pharmacol 1(1):10-20. Published online Feb 9, 2012. doi: 10.5497/wjp.v1.i1.10
41
Pharmacological role of efflux transporters: Clinical implications for medication use during breastfeeding  
Hilai Ahmadzai, Lisa BG Tee, Andrew Crowe 
World J Pharmacol 3(4):153-161. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.153
42
Telomerase activity: An attractive target for cancer therapeutics  
Lucia Picariello, Cecilia Grappone, Simone Polvani, Andrea Galli 
World J Pharmacol 3(4):86-96. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.86
43
Challenges and opportunities in the treatment of ulcerative colitis  
Sunil Ashokrao Nirmal, Sunil Shivaji Gangurde, Pratiksha Shankar Dumbre, Subodh Chandra Pal, Subhash Chandra Mandal 
World J Pharmacol 4(2):219-226. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.219
44
Protective effect of fu-qi granule on carbon tetrachloride-induced liver fibrosis in rats  
Lin Zhong, Yan-Ling Sun, Wen-Li Shi, Xiao Ma, Zhe Chen, Jia-Bo Wang, Rui-Sheng Li, Xue-Ai Song, Hong-Hong Liu, Yan-Ling Zhao, Xiao-He Xiao 
World J Pharmacol 4(2):227-235. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.227
45
Perspective of antiviral therapeutics for hepatitis C after liver transplantation  
Cheng-Maw Ho, Rey-Heng Hu, Po-Huang Lee 
World J Pharmacol 3(4):193-198. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.193
46
Therapeutic options and vaccine development in the treatment of leishmaniasis  
Jill E Weatherhead, Laila Woc-Colburn 
World J Pharmacol 4(2):210-218. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.210
47
Patents on antivirulence therapies  
María López, Beathriz Barbosa, Eva Gato, Germán Bou, María Tomás 
World J Pharmacol 3(4):97-109. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.97
48
49
Neurotrophic and metabotrophic potential of nerve growth factor and brain-derived neurotrophic factor: Linking cardiometabolic and neuropsychiatric diseases  
Stanislav Yanev, Luigi Aloe, Marco Fiore, George N Chaldakov 
World J Pharmacol 2(4):92-99. Published online Dec 9, 2013. doi: 10.5497/wjp.v2.i4.92
50
Nicotinic acid: Do we know how it works after 55 years of clinical experience  
Anastazia Kei, Moses S Elisaf 
World J Pharmacol 1(3):50-54. Published online Jun 9, 2012. doi: 10.5497/wjp.v1.i3.50