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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
Tobacco smoking and its drug interactions with comedications involving CYP and UGT enzymes and nicotine  
Naina Mohamed Pakkir Maideen 
World J Pharmacol 8(2):14-25. Published online Jan 30, 2019. doi: 10.5497/wjp.v8.i2.14
Ocular drug delivery systems: An overview  
Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra 
World J Pharmacol 2(2):47-64. Published online Jun 9, 2013. doi: 10.5497/wjp.v2.i2.47
Role of mitogen- and stress-activated kinases in inflammatory arthritis  
Sylvain G Bourgoin, Weili Hui 
World J Pharmacol 4(4):265-273. Published online Dec 9, 2015. doi: 10.5497/wjp.v4.i4.265
Drug delivery in ocular diseases: Barriers and strategies  
Deep Kwatra, Ashim K Mitra 
World J Pharmacol 2(4):78-83. Published online Dec 9, 2013. doi: 10.5497/wjp.v2.i4.78
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?  
Pamela J Weathers, Melissa Towler, Ahmed Hassanali, Pierre Lutgen, Patrick Ogwang Engeu 
World J Pharmacol 3(4):39-55. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.39
Therapeutic targets and delivery challenges for Alzheimer’s disease  
Preshita Desai, Harshad Shete, Rahul Adnaik, John Disouza, Vandana Patravale 
World J Pharmacol 4(3):236-264. Published online Sep 9, 2015. doi: 10.5497/wjp.v4.i3.236
Updates on therapies for chronic prostatitis/chronic pelvic pain syndrome  
Asfandyar Khan, Adam B Murphy 
World J Pharmacol 4(1):1-16. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.1
Novel strategies for the treatment of diabetic macular edema  
Hoang M Trinh, Mary Joseph, Kishore Cholkar, Dhananjay Pal, Ashim K Mitra 
World J Pharmacol 5(1):1-14. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.1
Non-selective beta-blockers in cirrhosis: Current concepts and controversies  
Neil Rajoriya, Dhiraj Tripathi 
World J Pharmacol 5(1):15-31. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.15
Tenofovir induced severe thrombocytopenia  
Mayank Jain, Joy Vargese, Jayanthi Venkatatraman 
World J Pharmacology 6(2):11-13. Published online Jun 9, 2017. doi: 10.5497/wjp.v6.i2.11
Appropriate prescribing in the elderly: Current perspectives  
Amanda Hanora Lavan, John O’Grady, Paul Francis Gallagher 
World J Pharmacol 4(2):193-209. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.193
How and why chemicals from tobacco smoke can induce a rise in blood pressure  
Aurelio Leone 
World J Pharmacol 1(1):10-20. Published online Feb 9, 2012. doi: 10.5497/wjp.v1.i1.10
Adalimumab and pharmacokinetics: Impact on the clinical prescription for inflammatory bowel disease  
Anne-Laure Pelletier, Pascale Nicaise-Roland 
World J Pharmacol 5(1):44-50. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.44
Bacterial biofilms in human gastrointestinal tract: An intricate balance between health and inflammatory bowel diseases  
Niharika Chandra, Ankita Srivastava, Sunil Kumar 
World J Pharmacol 8(3):26-40. Published online Aug 28, 2019. doi: 10.5497/wjp.v8.i3.26
Drug-transporter interaction testing in drug discovery and development  
Peter Krajcsi 
World J Pharmacol 2(1):35-46. Published online Mar 9, 2013. doi: 10.5497/wjp.v2.i1.35
Pharmacology and clinical applications of flupirtine: Current and future options  
Kim Lawson 
World J Pharmacology 8(1):1-13. Published online Jan 15, 2019. doi: 10.5497/wjp.v8.i1.1
Targeted approaches for HER2 breast cancer therapy: News from nanomedicine?  
Serena Mazzucchelli, Marta Truffi, Luisa Fiandra, Luca Sorrentino, Fabio Corsi 
World J Pharmacol 3(4):72-85. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.72
Phosphoprotein phosphatase 1-interacting proteins as therapeutic targets in prostate cancer  
Juliana Felgueiras, Margarida Fardilha 
World J Pharmacol 3(4):120-139. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.120
Carbapenemases: A worldwide threat to antimicrobial therapy  
José Miguel Sahuquillo-Arce, Alicia Hernández-Cabezas, Fernanda Yarad-Auad, Elisa Ibáñez-Martínez, Patricia Falomir-Salcedo, Alba Ruiz-Gaitán 
World J Pharmacol 4(1):75-95. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.75
Innovate combination of sevoflurane dilution in dimethyl sulfoxide: A stability study by gas chromatography and nuclear magnetic resonance  
F Dámaso Fernández-Ginés, Sergio García-Muñoz, Héctor Mateo-Carrasco, Miguel Ángel Rincón-Cervera, Manuel Cortiñas-Sáenz, José Antonio Morales-Molina, Carmen Fernández-Sánchez, Juan Miguel Expósito-López, Ignacio Rodríguez-García 
World J Pharmacology 5(3):59-67. Published online Sep 9, 2016. doi: 10.5497/wjp.v5.i3.59
Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia  
Shaun Hopper, Madhara Udawela, Elizabeth Scarr, Brian Dean 
World J Pharmacol 5(1):32-43. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.32
Chemoprevention of gastrointestinal cancers by natural honey  
Mohamed MM Abdel-Latif 
World J Pharmacol 4(1):160-167. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.160
Asthma in pregnancy  
Hayley K Blackburn, Douglas R Allington, Kendra A Procacci, Michael P Rivey 
World J Pharmacol 3(4):56-71. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.56
Role of opioid receptor heterodimerization in pain modulation and tolerance development  
Annu Mudgal, Santosh Pasha 
World J Pharmacol 4(1):144-159. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.144
Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement  
María L Cuestas, José R Oubiña, Verónica L Mathet 
World J Pharmacol 4(1):96-116. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.96
Pharmacophore approaches in protein kinase inhibitors design  
Sergiy A Starosyla, Galyna P Volynets, Volodymyr G Bdzhola, Andriy G Golub, Sergiy M Yarmoluk 
World J Pharmacol 3(4):162-173. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.162
Association of serum bilirubin and non-alcoholic fatty liver disease: A feasible therapeutic avenue?  
Mohamed S Anwar, John F Dillon, Michael H Miller 
World J Pharmacol 3(4):209-216. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.209
Implantable (Bio)sensors as new tools for wireless monitoring of brain neurochemistry in real time  
Donatella Farina, Maria D Alvau, Giulia Puggioni, Giammario Calia, Gianfranco Bazzu, Rossana Migheli, Ottavio Sechi, Gaia Rocchitta, Maria S Desole, Pier Andrea Serra 
World J Pharmacol 3(1):1-17. Published online Mar 9, 2014. doi: 10.5497/wjp.v3.i1.1
Drug therapy for Parkinson’s disease: An update  
Omar ME Abdel-Salam 
World J Pharmacol 4(1):117-143. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.117
Long-term potentiation in autonomic ganglia: Potential role in cardiovascular disorders  
Karim A Alkadhi 
World J Pharmacol 5(2):51-58. Published online Jun 9, 2016. doi: 10.5497/wjp.v5.i2.51
Pharmacological management of neuropathic pain in patients with vestibular schwannomas: Experience of the Atlantic Lateral Skull Base Clinic  
Andrea LO Hebb, Jana Sawynok, Manohar Bance, Simon Walling, Ken Chisholm, David P Morris 
World J Pharmacol 3(2):24-32. Published online Jun 9, 2014. doi: 10.5497/wjp.v3.i2.24
Antimicrobial resistance in clinically important biofilms  
Fatemeh Rafii, Mark E Hart 
World J Pharmacol 4(1):31-46. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.31
Overview on metabolomics in traditional Chinese medicine  
Shi Qiu, Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Xi-Jun Wang 
World J Pharmacol 3(3):33-38. Published online Sep 9, 2014. doi: 10.5497/wjp.v3.i3.33
Importance of microenvironment in preclinical models of breast and prostate cancer  
Maija Valta, Katja Fagerlund, Mari Suominen, Jussi Halleen, Johanna Tuomela 
World J Pharmacol 4(1):47-57. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.47
Potential ability of xanthophylls to prevent obesity-associated cancer  
Masaru Terasaki, Michihiro Mutoh, Gen Fujii, Mami Takahashi, Rikako Ishigamori, Sonoko Masuda 
World J Pharmacol 3(4):140-152. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.140
Telomerase activity: An attractive target for cancer therapeutics  
Lucia Picariello, Cecilia Grappone, Simone Polvani, Andrea Galli 
World J Pharmacol 3(4):86-96. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.86
Aryl hydrocarbon receptor as a new therapeutic target for cancer and immune disorders  
Libia Vega, Guillermo Elizondo 
World J Pharmacol 2(4):107-114. Published online Dec 9, 2013. doi: 10.5497/wjp.v2.i4.107
Progress in pancreatic cancer therapeutics: The potential to exploit molecular targets  
Kiruthikah Thillai, Debashis Sarker, Paul Ross 
World J Pharmacol 4(2):180-192. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.180
Levomilnacipran and vortioxetine: Review of new pharmacotherapies for major depressive disorder  
Mei T Liu, Megan E Maroney, Evelyn R Hermes-DeSantis 
World J Pharmacol 4(1):17-30. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.17
Utility of transporter/receptor(s) in drug delivery to the eye  
Sai HS Boddu, Jerry Nesamony 
World J Pharmacol 2(1):1-17. Published online Mar 9, 2013. doi: 10.5497/wjp.v2.i1.1
Improving cancer therapy by targeting cancer stem cells: Directions, challenges, and clinical results  
Pier Adelchi Ruffini, Valentina Vaja, Marcello Allegretti 
World J Pharmacol 4(1):58-74. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.58
Challenges and opportunities in the treatment of ulcerative colitis  
Sunil Ashokrao Nirmal, Sunil Shivaji Gangurde, Pratiksha Shankar Dumbre, Subodh Chandra Pal, Subhash Chandra Mandal 
World J Pharmacol 4(2):219-226. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.219
Arsenic exposure decreases rhythmic contractions of vascular tone through sodium transporters and K+ channels  
Javier Palacios, Chukwuemeka R Nwokocha, Fredi Cifuentes 
World J Pharmacol 3(2):18-23. Published online Jun 9, 2014. doi: 10.5497/wjp.v3.i2.18
Pharmacological role of efflux transporters: Clinical implications for medication use during breastfeeding  
Hilai Ahmadzai, Lisa BG Tee, Andrew Crowe 
World J Pharmacol 3(4):153-161. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.153
Protective effect of fu-qi granule on carbon tetrachloride-induced liver fibrosis in rats  
Lin Zhong, Yan-Ling Sun, Wen-Li Shi, Xiao Ma, Zhe Chen, Jia-Bo Wang, Rui-Sheng Li, Xue-Ai Song, Hong-Hong Liu, Yan-Ling Zhao, Xiao-He Xiao 
World J Pharmacol 4(2):227-235. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.227