Published online Mar 9, 2014. doi: 10.5497/wjp.v3.i1.1
Revised: March 3, 2014
Accepted: March 6, 2014
Published online: March 9, 2014
Core tip: Electrochemical microsensors and amperometric biosensors arouse enormous scientific interest because of their low-cost technology and because they guarantee real-time monitoring of changes of the most important brain compounds. In conjunction with miniaturized telemetric devices, the electrochemical sensors, allow the neurochemical monitoring of extracellular space of discrete brain regions in awake, untethered animals for days or weeks. This new scientific approach opens new frontiers for studying the physiological and physiopathological pathways in wild-type animals and in genetic models of the most widespread neurodegenerative diseases.