Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.86
Revised: October 1, 2014
Accepted: October 28, 2014
Published online: December 9, 2014
Core tip: One of the hallmark of cancer is the replicative immortality of tumor cells guaranteed by telomerase activity that counteracts progressive telomere shortening during cellular replication: this makes telomerase a tumor marker and a target for anticancer drugs. In this review we summarize and update the most recent innovative studies and results on the different strategies that consider telomerase as a target for cancer therapy. In particular, we try to point out the advantages and the potentialities of some innovative approaches, compared to other, equally promising, but that need further investigations.