Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Pharmacol. Mar 9, 2015; 4(1): 58-74
Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.58
Improving cancer therapy by targeting cancer stem cells: Directions, challenges, and clinical results
Pier Adelchi Ruffini, Valentina Vaja, Marcello Allegretti
Pier Adelchi Ruffini, Valentina Vaja, Marcello Allegretti, Research and Development Department, Dompé Farmaceutici S.p.A., 20122 Milano, Italy
Author contributions: Ruffini PA, Vaja V and Allegretti M contributed to this paper.
Conflict-of-interest: Pier Adelchi Ruffini, Valentina Vaja and Marcello Allegretti are employees of Dompé Farmaceutici S.p.A.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Pier Adelchi Ruffini, MD, PhD, Research and Development Department, Dompé Farmaceutici S.p.A., via S. Lucia 6, 20122 Milano, Italy.
Telephone: +39-02-58383500 Fax: +39-02-58383324
Received: September 30, 2014
Peer-review started: October 1, 2014
First decision: October 28, 2014
Revised: November 26, 2014
Accepted: February 9, 2015
Article in press: February 11, 2015
Published online: March 9, 2015
Core Tip

Core tip: Cancer stem cells are a rare cell population with two embedded fundamental properties: self-renewal and differentiation into the heterogeneous lineages of cancer cells that comprise the tumor. While the identification and role of such cells has been clearly established in vitro and in animal models, uncertainty remains as to the role they play in human tumors and their relevance as therapeutic targets. The article summarizes and discusses the latest findings and challenges on cancer stem cell research, the significance of these cells beyond experimental models and suggests avenues for development of cancer stem cell targeting agents.