Published online Jan 30, 2019. doi: 10.5497/wjp.v8.i2.14
Peer-review started: November 14, 2018
First decision: December 18, 2018
Revised: January 20, 2019
Accepted: January 28, 2019
Article in press: January 28, 2019
Published online: January 30, 2019
Core tip: Use of medications among smokers is more common, nowadays. This review is aimed to identify the medications affected by smoking, involving cytochrome P450 (CYP) and uridine diphosphate-glucuronosyltransferases (UGTs) enzymes and Nicotine. The drugs metabolized by CYP1A1, CYP1A2, CYP2E1 and UGT enzymes might be affected by tobacco smoking and the smokers taking medications metabolized by those enzymes, may need higher doses due to decreased plasma concentrations through accelerated metabolism by Polycyclic aromatic hydrocarbons of tobacco smoke. The prescribers and the pharmacists are required to be aware of medications affected by tobacco smoking to prevent the toxicity-associated complications during smoking cessation.