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World J Pharmacol. Jun 9, 2014; 3(2): 18-23
Published online Jun 9, 2014. doi: 10.5497/wjp.v3.i2.18
Arsenic exposure decreases rhythmic contractions of vascular tone through sodium transporters and K+ channels
Javier Palacios, Chukwuemeka R Nwokocha, Fredi Cifuentes
Javier Palacios, Departamento de Ciencias Químicas y Farmacéuticas, Universidad Arturo Prat, Iquique 1110939, Chile
Chukwuemeka R Nwokocha, Department of Basic Medical Science, Physiology Section, University of The West Indies, Mona Kingston JMAKN, Jamaica
Fredi Cifuentes, Experimental Physiology Laboratory, Instituto Antofagasta, Universidad de Antofagasta, Antofagasta 02800, Chile
Author contributions: Palacios J wrote the paper; Nwokocha CR and Cifuentes F revised the paper.
Correspondence to: Javier Palacios, PhD, Departamento de Ciencias Químicas y Farmacéuticas, Universidad Arturo Prat, Av. Arturo Prat Chacón, 2120, Iquique 1110939, Chile.
Telephone: +56-57-2526910 Fax: +56-57-2526210
Received: April 5, 2014
Revised: June 4, 2014
Accepted: June 5, 2014
Published online: June 9, 2014
Core Tip

Core tip: Vascular tone is regulated in part by cytosolic calcium oscillations. Arsenic can induce an increase in vascular tone and resistance. We suggest a model explaining the participation of the sodium pump and Na+-K+-2Cl- co-transporter in low dose arsenic exposure effects on vasomotion and vascular dysfunction.