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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Tobacco smoking and its drug interactions with comedications involving CYP and UGT enzymes and nicotine  
Naina Mohamed Pakkir Maideen 
World J Pharmacol 8(2):14-25. Published online Jan 30, 2019. doi: 10.5497/wjp.v8.i2.14
2
Ocular drug delivery systems: An overview  
Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra 
World J Pharmacol 2(2):47-64. Published online Jun 9, 2013. doi: 10.5497/wjp.v2.i2.47
3
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?  
Patrick Ogwang Engeu, Pierre Lutgen, Ahmed Hassanali, Melissa Towler, Pamela J Weathers 
World J Pharmacol 3(4):39-55. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.39
4
Role of mitogen- and stress-activated kinases in inflammatory arthritis  
Weili Hui, Sylvain G Bourgoin 
World J Pharmacol 4(4):265-273. Published online Dec 9, 2015. doi: 10.5497/wjp.v4.i4.265
5
Updates on therapies for chronic prostatitis/chronic pelvic pain syndrome  
Asfandyar Khan, Adam B Murphy 
World J Pharmacol 4(1):1-16. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.1
6
Therapeutic targets and delivery challenges for Alzheimer’s disease  
Preshita Desai, Harshad Shete, Rahul Adnaik, John Disouza, Vandana Patravale 
World J Pharmacol 4(3):236-264. Published online Sep 9, 2015. doi: 10.5497/wjp.v4.i3.236
7
Drug delivery in ocular diseases: Barriers and strategies  
Ashim K Mitra, Deep Kwatra 
World J Pharmacol 2(4):78-83. Published online Dec 9, 2013. doi: 10.5497/wjp.v2.i4.78
8
Controversial usages of kratom (Mitragyna speciosa): For good or for evil  
Murtadha Basheer, Rana Khudhair Jasim, Gam Lay Harn 
World J Pharmacol 11(3):16-26. Published online Nov 28, 2022. doi: 10.5497/wjp.v11.i3.16
9
Novel strategies for the treatment of diabetic macular edema  
Hoang M Trinh, Mary Joseph, Kishore Cholkar, Dhananjay Pal, Ashim K Mitra 
World J Pharmacol 5(1):1-14. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.1
10
Appropriate prescribing in the elderly: Current perspectives  
Amanda Hanora Lavan, John O’Grady, Paul Francis Gallagher 
World J Pharmacol 4(2):193-209. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.193
11
Non-selective beta-blockers in cirrhosis: Current concepts and controversies  
Neil Rajoriya, Dhiraj Tripathi 
World J Pharmacol 5(1):15-31. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.15
12
How and why chemicals from tobacco smoke can induce a rise in blood pressure  
Aurelio Leone 
World J Pharmacol 1(1):10-20. Published online Feb 9, 2012. doi: 10.5497/wjp.v1.i1.10
13
Tenofovir induced severe thrombocytopenia  
Mayank Jain, Joy Vargese, Jayanthi Venkatatraman 
World J Pharmacology 6(2):11-13. Published online Jun 9, 2017. doi: 10.5497/wjp.v6.i2.11
14
Adalimumab and pharmacokinetics: Impact on the clinical prescription for inflammatory bowel disease  
Anne-Laure Pelletier, Pascale Nicaise-Roland 
World J Pharmacol 5(1):44-50. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.44
15
Emerging pharmacological strategies for the treatment of fibromyalgia  
Kim Lawson 
World J Pharmacology 6(1):1-10. Published online Mar 9, 2017. doi: 10.5497/wjp.v6.i1.1
16
Pharmacology and clinical applications of flupirtine: Current and future options  
Kim Lawson 
World J Pharmacology 8(1):1-13. Published online Jan 15, 2019. doi: 10.5497/wjp.v8.i1.1
17
18
Chemoprevention of gastrointestinal cancers by natural honey  
Mohamed MM Abdel-Latif 
World J Pharmacol 4(1):160-167. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.160
19
Bacterial biofilms in human gastrointestinal tract: An intricate balance between health and inflammatory bowel diseases  
Sunil Kumar, Ankita Srivastava, Niharika Chandra 
World J Pharmacol 8(3):26-40. Published online Aug 28, 2019. doi: 10.5497/wjp.v8.i3.26
20
Phosphoprotein phosphatase 1-interacting proteins as therapeutic targets in prostate cancer  
Juliana Felgueiras, Margarida Fardilha 
World J Pharmacol 3(4):120-139. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.120
21
Drug-transporter interaction testing in drug discovery and development  
Peter Krajcsi 
World J Pharmacol 2(1):35-46. Published online Mar 9, 2013. doi: 10.5497/wjp.v2.i1.35
22
Innovate combination of sevoflurane dilution in dimethyl sulfoxide: A stability study by gas chromatography and nuclear magnetic resonance  
F Dámaso Fernández-Ginés, Sergio García-Muñoz, Héctor Mateo-Carrasco, Miguel Ángel Rincón-Cervera, Manuel Cortiñas-Sáenz, José Antonio Morales-Molina, Carmen Fernández-Sánchez, Juan Miguel Expósito-López, Ignacio Rodríguez-García 
World J Pharmacology 5(3):59-67. Published online Sep 9, 2016. doi: 10.5497/wjp.v5.i3.59
23
Targeted approaches for HER2 breast cancer therapy: News from nanomedicine?  
Serena Mazzucchelli, Marta Truffi, Luisa Fiandra, Luca Sorrentino, Fabio Corsi 
World J Pharmacol 3(4):72-85. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.72
24
Carbapenemases: A worldwide threat to antimicrobial therapy  
José Miguel Sahuquillo-Arce, Alicia Hernández-Cabezas, Fernanda Yarad-Auad, Elisa Ibáñez-Martínez, Patricia Falomir-Salcedo, Alba Ruiz-Gaitán 
World J Pharmacol 4(1):75-95. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.75
25
Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia  
Shaun Hopper, Madhara Udawela, Elizabeth Scarr, Brian Dean 
World J Pharmacol 5(1):32-43. Published online Mar 9, 2016. doi: 10.5497/wjp.v5.i1.32
26
Pharmacophore approaches in protein kinase inhibitors design  
Sergiy A Starosyla, Galyna P Volynets, Volodymyr G Bdzhola, Andriy G Golub, Sergiy M Yarmoluk 
World J Pharmacol 3(4):162-173. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.162
27
Asthma in pregnancy  
Hayley K Blackburn, Douglas R Allington, Kendra A Procacci, Michael P Rivey 
World J Pharmacol 3(4):56-71. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.56
28
Role of opioid receptor heterodimerization in pain modulation and tolerance development  
Annu Mudgal, Santosh Pasha 
World J Pharmacol 4(1):144-159. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.144
29
Drug therapy for Parkinson’s disease: An update  
Omar ME Abdel-Salam 
World J Pharmacol 4(1):117-143. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.117
30
Association of serum bilirubin and non-alcoholic fatty liver disease: A feasible therapeutic avenue?  
Mohamed S Anwar, John F Dillon, Michael H Miller 
World J Pharmacol 3(4):209-216. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.209
31
Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement  
María L Cuestas, José R Oubiña, Verónica L Mathet 
World J Pharmacol 4(1):96-116. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.96
32
Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole  
Syed Mujtaba Hussain Naqvi, Monil Yogesh Neena Gala, Snehal Muchhala, Anand Arumugam, Dhananjay Panigrahi, Dipak Patil, Rahul Rathod, Amey Mane 
World J Pharmacol 12(1):1-11. Published online Feb 17, 2023. doi: 10.5497/wjp.v12.i1.1
33
Long-term potentiation in autonomic ganglia: Potential role in cardiovascular disorders  
Karim A Alkadhi 
World J Pharmacol 5(2):51-58. Published online Jun 9, 2016. doi: 10.5497/wjp.v5.i2.51
34
Overview on metabolomics in traditional Chinese medicine  
Shi Qiu, Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Xi-Jun Wang 
World J Pharmacol 3(3):33-38. Published online Sep 9, 2014. doi: 10.5497/wjp.v3.i3.33
35
Implantable (Bio)sensors as new tools for wireless monitoring of brain neurochemistry in real time  
Donatella Farina, Maria D Alvau, Giulia Puggioni, Giammario Calia, Gianfranco Bazzu, Rossana Migheli, Ottavio Sechi, Gaia Rocchitta, Maria S Desole, Pier Andrea Serra 
World J Pharmacol 3(1):1-17. Published online Mar 9, 2014. doi: 10.5497/wjp.v3.i1.1
36
Pharmacological management of neuropathic pain in patients with vestibular schwannomas: Experience of the Atlantic Lateral Skull Base Clinic  
Andrea LO Hebb, Jana Sawynok, Manohar Bance, Simon Walling, Ken Chisholm, David P Morris 
World J Pharmacol 3(2):24-32. Published online Jun 9, 2014. doi: 10.5497/wjp.v3.i2.24
37
Use of eltrombopag in thrombocytopenia of liver disease  
Vishal Sharma 
World J Pharmacol 3(4):186-192. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.186
38
Potential ability of xanthophylls to prevent obesity-associated cancer  
Masaru Terasaki, Michihiro Mutoh, Gen Fujii, Mami Takahashi, Rikako Ishigamori, Sonoko Masuda 
World J Pharmacol 3(4):140-152. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.140
39
Antimicrobial resistance in clinically important biofilms  
Fatemeh Rafii, Mark E Hart 
World J Pharmacol 4(1):31-46. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.31
40
Progress in pancreatic cancer therapeutics: The potential to exploit molecular targets  
Kiruthikah Thillai, Debashis Sarker, Paul Ross 
World J Pharmacol 4(2):180-192. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.180
41
Recurrent ciprofloxacin induced hypoglycemia in a non-diabetic patient: A case report  
Shereen A Dasuqi, Linah M Alshaer, Rasha A Omran, Mohammed A Hamad 
World J Pharmacol 12(2):12-17. Published online Mar 22, 2023. doi: 10.5497/wjp.v12.i2.12
42
Antibiotic residues in milk and milk products: A momentous challenge for the pharmaceutical industry and medicine  
Rima Omairi, Maha Krayem, Sanaa Khaled, Mohamed Salla, Sami El Khatib 
World J Pharmacol 11(4):48-55. Published online Dec 27, 2022. doi: 10.5497/wjp.v11.i4.48
43
Telomerase activity: An attractive target for cancer therapeutics  
Lucia Picariello, Cecilia Grappone, Simone Polvani, Andrea Galli 
World J Pharmacol 3(4):86-96. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.86
44
Vitamin D and bone fracture healing  
Marks Ray 
World J Pharmacol 3(4):199-208. Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.199
45
46
Importance of microenvironment in preclinical models of breast and prostate cancer  
Maija Valta, Katja Fagerlund, Mari Suominen, Jussi Halleen, Johanna Tuomela 
World J Pharmacol 4(1):47-57. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.47
47
Aryl hydrocarbon receptor as a new therapeutic target for cancer and immune disorders  
Libia Vega, Guillermo Elizondo 
World J Pharmacol 2(4):107-114. Published online Dec 9, 2013. doi: 10.5497/wjp.v2.i4.107
48
Challenges and opportunities in the treatment of ulcerative colitis  
Sunil Ashokrao Nirmal, Sunil Shivaji Gangurde, Pratiksha Shankar Dumbre, Subodh Chandra Pal, Subhash Chandra Mandal 
World J Pharmacol 4(2):219-226. Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.219
49
Levomilnacipran and vortioxetine: Review of new pharmacotherapies for major depressive disorder  
Mei T Liu, Megan E Maroney, Evelyn R Hermes-DeSantis 
World J Pharmacol 4(1):17-30. Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.17
50
Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice: Highlighting effects on behaviour, oxidative stress, and neuroinflammation  
Olakunle James Onaolapo, Anthony Tope Olofinnade, Hameed Sulaiman, Adejoke Yetunde Onaolapo 
World J Pharmacol 11(3):27-47. Published online Nov 28, 2022. doi: 10.5497/wjp.v11.i3.27
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