Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.209
Revised: October 15, 2014
Accepted: October 23, 2014
Published online: December 9, 2014
Core tip: This systematic review summarises and highlights the deficiencies in the current studies on the association of serum bilirubin with non-alcoholic fatty liver disease (NAFLD). It explores the potential underpinning of the mechanistic association of NAFLD with bilirubin. Potential novel therapeutic avenues of bilirubin are explored in NAFLD, a common condition with oxidative damage as a core pathogenetic factor. Although this area of study is still in its infancy, this review is a timely summary of current key studies in this subject area and provides an up to date thought perspective with focus on future direction and potential therapeutic application.