Published online Sep 9, 2015. doi: 10.5497/wjp.v4.i3.236
Peer-review started: November 23, 2014
First decision: December 12, 2014
Revised: May 29, 2015
Accepted: August 10, 2015
Article in press: August 11, 2015
Published online: September 9, 2015
Core tip: Dementia, including Alzheimer’s disease, the 21st Century epidemic, is one of the most significant social and health crises which has currently afflicted nearly 44 million patients worldwide and is on rampant rise. This portrays the unmet need towards better understanding of Alzheimer’s disease pathomechanisms and related research towards more effective treatment strategies. The review thus focuses on thorough understanding of Alzheimer’s disease pathophysiology, pharmacotherapy in terms of explored therapeutic targets and drug delivery systems towards better delivery of anti-Alzheirmer actives and a possible way ahead.