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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Role of cytokines and other factors involved in the Mycobacterium tuberculosis infection  
Tania Beatriz Romero-Adrian, Jorymar Leal-Montiel, Gerardo Fernández, Alejandra Valecillo 
World J Immunol 5(1):16-50. Published online Mar 27, 2015. doi: 10.5411/wji.v5.i1.16
2
Dendritic cells and the extracellular matrix: A challenge for maintaining tolerance/homeostasis  
Sucharita P Shankar, May Griffith, John V Forrester, Lucia Kuffová 
World J Immunol 5(3):113-130. Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.113
3
Present and future of immune checkpoint blockade: Monotherapy to adjuvant approaches  
Mira A Patel, Jennifer E Kim, Jacob Ruzevick, Michael Lim 
World J Immunol 5(1):1-15. Published online Mar 27, 2015. doi: 10.5411/wji.v5.i1.1
4
Crucial roles of macrophages in the pathogenesis of autoimmune disease  
Aya Ushio, Rieko Arakaki, Akiko Yamada, Masako Saito, Takaaki Tsunematsu, Yasusei Kudo, Naozumi Ishimaru 
World J Immunol 7(1):1-8. Published online Mar 27, 2017. doi: 10.5411/wji.v7.i1.1
5
CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells  
Isabel T Vogel, Stefaan W Van Gool, Jan L Ceuppens 
World J Immunol 4(2):63-77. Published online Jul 27, 2014. doi: 10.5411/wji.v4.i2.63
6
Maillard reaction and immunogenicity of protein therapeutics  
Rositsa Tsekovska, Angelina Sredovska-Bozhinov, Toshimitsu Niwa, Ivan Ivanov, Roumyana Mironova 
World J Immunol 6(1):19-38. Published online Mar 27, 2016. doi: 10.5411/wji.v6.i1.19
7
Antimicrobial lipids: Emerging effector molecules of innate host defense  
Edith Porter, Daniel C Ma, Sandy Alvarez, Kym F Faull 
World J Immunol 5(2):51-61. Published online Jul 27, 2015. doi: 10.5411/wji.v5.i2.51
8
Immunopathogenesis of reactive arthritis: Role of the cytokines  
Ricardo Javier Eliçabe, María Silvia Di Genaro 
World J Immunol 4(2):78-87. Published online Jul 27, 2014. doi: 10.5411/wji.v4.i2.78
9
10
Essential vitamins for an effective T cell response  
Ritobrata Goswami, Mark H Kaplan 
World J Immunol 6(1):39-59. Published online Mar 27, 2016. doi: 10.5411/wji.v6.i1.39
11
GRP78 expression beyond cellular stress: A biomarker for tumor manipulation  
Britta Hardy, Annat Raiter 
World J Immunol 5(2):78-85. Published online Jul 27, 2015. doi: 10.5411/wji.v5.i2.78
12
Macrophage populations and self-renewal: Changing the paradigm  
Rym Belhareth, Jean-Louis Mège 
World J Immunol 5(3):131-141. Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.131
13
Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects  
Eleonora Reginato, Peter Wolf, Michael R Hamblin 
World J Immunol 4(1):1-11. Published online Mar 27, 2014. doi: 10.5411/wji.v4.i1.1
14
Intracellular localisation of Mycobacterium marinum in mast cells  
Sadiyo Siad, Simon Byrne, Galina Mukamolova, Cordula Stover 
World J Immunol 6(1):83-95. Published online Mar 27, 2016. doi: 10.5411/wji.v6.i1.83
15
Recent advances of cluster of differentiation 74 in cancer  
Yu-Huei Liu, Jung-Yaw Lin 
World J Immunol 4(3):174-184. Published online Nov 27, 2014. doi: 10.5411/wji.v4.i3.174
16
17
Role of the clinical immunology laboratory in disease monitoring  
John Maher 
World J Immunol 3(2):18-30. Published online Jul 27, 2013. doi: 10.5411/wji.v3.i2.18
18
Regulatory T cells suppress autoreactive CD4+ T cell response to bladder epithelial antigen  
Wu-Jiang Liu, Yi Luo 
World J Immunol 6(2):105-118. Published online Jul 27, 2016. doi: 10.5411/wji.v6.i2.105
19
Immunological aspects of drug-induced liver injury  
Kazuto Tajiri, Yukihiro Shimizu 
World J Immunol 4(3):149-157. Published online Nov 27, 2014. doi: 10.5411/wji.v4.i3.149
20
Apoptotic signaling through reactive oxygen species in cancer cells  
Daejin Kim, Ga Bin Park, Dae Young Hur 
World J Immunol 4(3):158-173. Published online Nov 27, 2014. doi: 10.5411/wji.v4.i3.158
21
Noncanonical intercellular communication in immune response  
Malgorzata Kloc, Jacek Z Kubiak, Xian C Li, Rafik M Ghobrial 
World J Immunol 6(1):67-74. Published online Mar 27, 2016. doi: 10.5411/wji.v6.i1.67
22
RNA polymerases in plasma cells trav-ELL2 the beat of a different drum  
Sage M Smith, Nolan T Carew, Christine Milcarek 
World J Immunol 5(3):99-112. Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.99
23
24
Gut immune response in the presence of hepatitis C virus infection  
Helal F Hetta, Minesh J Mehta, Mohamed Tarek M Shata 
World J Immunol 4(2):52-62. Published online Jul 27, 2014. doi: 10.5411/wji.v4.i2.52
25
Role of tumor associated macrophages in regulating pancreatic cancer progression  
Raul Caso, George Miller 
World J Immunol 6(1):9-18. Published online Mar 27, 2016. doi: 10.5411/wji.v6.i1.9
26
Lessons from Sjögren’s syndrome etiopathogenesis: Novel cellular and molecular targets  
José C Crispín, Florencia Rosetti, Gabriela Hernández-Molina 
World J Immunol 5(3):152-159. Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.152
27
28
Update on pythiosis immunobiology and immunotherapy  
Érico S Loreto, Juliana SM Tondolo, Régis A Zanette, Sydney H Alves, Janio M Santurio 
World J Immunol 4(2):88-97. Published online Jul 27, 2014. doi: 10.5411/wji.v4.i2.88
29
30
Role of interleukin-1-family cytokines on effector CD4 T cell differentiation  
Thaiz Rivera Vargas, François Martin, Lionel Apetoh 
World J Immunol 7(2):24-31. Published online Jul 27, 2017. doi: 10.5411/wji.v7.i2.24
31
Probiotics in inflammatory bowel disease: Pathophysiological background and clinical applications  
Cristiano Pagnini, Gianfranco Delle Fave, Giorgos Bamias 
World J Immunol 3(3):31-43. Published online Nov 27, 2013. doi: 10.5411/wji.v3.i3.31
32
Holistic paradigm in carcinogenesis: Genetics, epigenetics, immunity, inflammation and oral infections  
Sok-Ja Janket, Marium Qureshi, Antonio Bascones-Martinez, Jerian González-Febles, Jukka H Meurman 
World J Immunol 7(2):11-23. Published online Jul 27, 2017. doi: 10.5411/wji.v7.i2.11
33
Modulation of monocyte subsets in infectious diseases  
Mignane B Ka, Daniel Olive, Jean-Louis Mege 
World J Immunol 4(3):185-193. Published online Nov 27, 2014. doi: 10.5411/wji.v4.i3.185
34
Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis  
Cong Yan, Hong Du 
World J Immunol 4(2):42-51. Published online Jul 27, 2014. doi: 10.5411/wji.v4.i2.42
35
Chimeric antigen receptors: On the road to realising their full potential  
May CI van Schalkwyk, John Maher 
World J Immunol 5(3):86-94. Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.86
36
Dynamic interplay of T helpercell subsets in experimental autoimmune encephalomyelitis  
Crystal C Walline, Saravanan Kanakasabai, John J Bright 
World J Immunol 2(1):1-13. Published online Feb 27, 2012. doi: 10.5411/wji.v2.i1.1
37
Penicillamine and auto-immunity: Relationship or coincidence?  
Sofia Santos, Raquel Faria 
World J Immunol 7(1):9-10. Published online Mar 27, 2017. doi: 10.5411/wji.v7.i1.9
38
Cigarette smoking and innate immune responses to influenza infection  
Wenxin Wu, Jordan P Metcalf 
World J Immunol 4(1):20-25. Published online Mar 27, 2014. doi: 10.5411/wji.v4.i1.20
39
Decoy receptor 3: Its role as biomarker for chronic inflammatory diseases  
Spyros I Siakavellas, Giorgos Bamias 
World J Immunol 3(3):44-53. Published online Nov 27, 2013. doi: 10.5411/wji.v3.i3.44
40
Review of immunological responses to porcine coronaviruses and implications on population based control strategies in epidemic and endemic infections  
Elsa Kanner-Acerbo, James Lowe 
World J Immunol 6(1):60-66. Published online Mar 27, 2016. doi: 10.5411/wji.v6.i1.60
41
Epigenomic revolution in autoimmune diseases  
Christelle Le Dantec, Wesley H Brooks, Yves Renaudineau 
World J Immunol 5(2):62-67. Published online Jul 27, 2015. doi: 10.5411/wji.v5.i2.62
42
Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis  
Rubén Varela-Calviño, Oscar J Cordero 
World J Immunol 5(2):68-77. Published online Jul 27, 2015. doi: 10.5411/wji.v5.i2.68
43
New insights on chitinases immunologic activities  
Michelino Di Rosa, Violetta Maria Brundo, Lucia Malaguarnera 
World J Immunol 6(2):96-104. Published online Jul 27, 2016. doi: 10.5411/wji.v6.i2.96
44
Immune thrombocytopenia in adults  
Erdal Kurtoğlu, Volkan Karakuş 
World J Immunol 4(1):34-41. Published online Mar 27, 2014. doi: 10.5411/wji.v4.i1.34
45
Role of host immune responses in sequence variability of HIV-1 Vpu  
Zafrul Hasan, Doreen Kamori, Takamasa Ueno 
World J Immunol 4(2):107-115. Published online Jul 27, 2014. doi: 10.5411/wji.v4.i2.107
46
Circulating immune cell activation and diet: A review on human trials  
Gemma Chiva-Blanch, Ramon Estruch 
World J Immunol 4(1):12-19. Published online Mar 27, 2014. doi: 10.5411/wji.v4.i1.12
47
Targeting TLR4/MAPKs signaling pathway: A better option for therapeutic inhibition of atherosclerosis  
Janeesh Plakkal Ayyappan, Annie Abraham 
World J Immunol 4(2):116-121. Published online Jul 27, 2014. doi: 10.5411/wji.v4.i2.116
48
Myeloid derived suppressor cells in breast cancer: A novel therapeutic target?  
Rebekah M Weston, Cordula M Stover 
World J Immunol 6(3):119-125. Published online Nov 27, 2016. doi: 10.5411/wji.v6.i3.119
49
Impact of cell death manipulation on the efficacy of photodynamic therapy-generated cancer vaccines  
Mladen Korbelik 
World J Immunol 5(3):95-98. Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.95
50
Transgenic plants for allergen-specific immunotherapy  
Tomoe Nishimura, Mayumi Saeki, Osamu Kaminuma, Fumio Takaiwa, Takachika Hiroi 
World J Immunol 4(3):141-148. Published online Nov 27, 2014. doi: 10.5411/wji.v4.i3.141