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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Immunol. Nov 27, 2015; 5(3): 131-141
Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.131
Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.131
Macrophage populations and self-renewal: Changing the paradigm
Rym Belhareth, Jean-Louis Mège, URMITE, Faculté de Médecine, 13005 Marseille, France
Rym Belhareth, Laboratoire de Neurophysiologie Fonctionnelle et Pathologies UR/11ES09, FST Campus Universitaire, 2092 El Manar Tunis, Tunisie
Author contributions: Belhareth R and Mège JL contributed to this paper.
Conflict-of-interest statement: Authors declare no conflict of interests for this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jean-Louis Mège, MD, PhD, URMITE, Faculté de Médecine, 27 Bld. Jean Moulin, 13005 Marseille, France. jean-louis.mege@univ-amu.fr
Telephone: +33-491-324970 Fax: +33-491-324306
Received: July 9, 2015
Peer-review started: July 14, 2015
First decision: July 31, 2015
Revised: October 10, 2015
Accepted: October 23, 2015
Article in press: October 27, 2015
Published online: November 27, 2015
Peer-review started: July 14, 2015
First decision: July 31, 2015
Revised: October 10, 2015
Accepted: October 23, 2015
Article in press: October 27, 2015
Published online: November 27, 2015
Core Tip
Core tip: The emergence of revolutionary technologies in myeloid cell research has deeply changed the paradigm of macrophage activation. It was believed that macrophage derive from myeloid precursors via circulating monocytes. Now, we can propose that resident macrophages are of embryonic origin in steady state whereas monocytes are recruited in pathological conditions. The second strong idea was that mature macrophages are unable to proliferate; we have strong evidence that macrophages can proliferate, which is the basis of self-renewal. The consequences of these new concepts will lead us to reappraise the role of macrophages in pathologies.