Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.160
Peer-review started: April 21, 2015
First decision: May 13, 2015
Revised: July 18, 2015
Accepted: September 10, 2015
Article in press: September 16, 2015
Published online: November 27, 2015
In this review, we have focused on the effects of exercise on infection or antibody production. In the past, exercise immunologists largely focused on exercise and its effects on infection. Research on the effects of exercise on antibody response began in the 1970s with a primary focus on whether regular exercise helps to minimize the risk of infection. Positive results from these early studies indicated that exercise affects higher survival rate. Based on the results of these studies, researchers then investigated the exercise-induced elevation of plasma antibody levels. It has been suggested that exercise of moderate intensity could be a helpful and effective adjuvant for human health. Other studies have examined the effects of exercise on antibody-producing cells, and the levels of protection conferred by the produced antibodies. We have attempted to summarize the current understanding of exercise-induced elevations in plasma antibody levels. We also propose some future directions for investigating the relationship between exercise and antibody response.
Core tip: Exercise-induced plasma antibody elevation is now recognized as a key recall response to vaccine antigens. In exercised mice, antigen-specific antibody producing cells harvested more and their elongated half-life of the produced antibodies, resulted in their evoked secondary IgG responses. Here, we review the effects of exercise on antibody response.