Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Immunol. Nov 27, 2015; 5(3): 160-166
Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.160
Effects of exercise on antibody production
Kotaro Suzuki
Kotaro Suzuki, Faculty of Health and Sports Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574, Japan
Author contributions: Suzuki K collected all documents, reviewed the published articles, and wrote the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Kotaro Suzuki, PhD, Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tenoudai, Tsukuba, Ibaraki 305-8574, Japan.
Telephone: +81-29-8532734 Fax: +81-29-8536507
Received: April 17, 2015
Peer-review started: April 21, 2015
First decision: May 13, 2015
Revised: July 18, 2015
Accepted: September 10, 2015
Article in press: September 16, 2015
Published online: November 27, 2015

In this review, we have focused on the effects of exercise on infection or antibody production. In the past, exercise immunologists largely focused on exercise and its effects on infection. Research on the effects of exercise on antibody response began in the 1970s with a primary focus on whether regular exercise helps to minimize the risk of infection. Positive results from these early studies indicated that exercise affects higher survival rate. Based on the results of these studies, researchers then investigated the exercise-induced elevation of plasma antibody levels. It has been suggested that exercise of moderate intensity could be a helpful and effective adjuvant for human health. Other studies have examined the effects of exercise on antibody-producing cells, and the levels of protection conferred by the produced antibodies. We have attempted to summarize the current understanding of exercise-induced elevations in plasma antibody levels. We also propose some future directions for investigating the relationship between exercise and antibody response.

Keywords: Antibody, Exercise, Circulating IgG, Liver, β2-microglobulin

Core tip: Exercise-induced plasma antibody elevation is now recognized as a key recall response to vaccine antigens. In exercised mice, antigen-specific antibody producing cells harvested more and their elongated half-life of the produced antibodies, resulted in their evoked secondary IgG responses. Here, we review the effects of exercise on antibody response.