Di Rosa M, Brundo VM, Malaguarnera L. New insights on chitinases immunologic activities. World J Immunol 2016; 6(2): 96-104 [DOI: 10.5411/wji.v6.i2.96]
Corresponding Author of This Article
Lucia Malaguarnera, MD, PhD, Professor, Department of Biomedical and Biotechnology Sciences, University of Catania, 95124 Catania, Italy. lucmal@unict.it
Research Domain of This Article
Immunology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Immunol. Jul 27, 2016; 6(2): 96-104 Published online Jul 27, 2016. doi: 10.5411/wji.v6.i2.96
New insights on chitinases immunologic activities
Michelino Di Rosa, Violetta Maria Brundo, Lucia Malaguarnera
Michelino Di Rosa, Lucia Malaguarnera, Department of Biomedical and Biotechnology Sciences, University of Catania, 95124 Catania, Italy
Violetta Maria Brundo, Department of Biological, Geological and Environmental Sciences, University of Catania, 95124 Catania, Italy
Author contributions: Di Rosa M analyzed and interpreted the data; Brundo VM collected the data; Malaguarnera L wrote the paper.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lucia Malaguarnera, MD, PhD, Professor, Department of Biomedical and Biotechnology Sciences, University of Catania, 95124 Catania, Italy. lucmal@unict.it
Telephone: +39-095-313429 Fax: +39-095-320267
Received: June 28, 2015 Peer-review started: July 5, 2015 First decision: September 17, 2015 Revised: March 15, 2016 Accepted: April 7, 2016 Article in press: April 11, 2016 Published online: July 27, 2016
Core Tip
Core tip: The chitinases and chitinase-like proteins are expressed in response to different pro-inflammatory signals by activated macrophages and in different monocyte-derived cell lines. The mechanism and molecular interaction of chitinases in the immune regulation embrace bacterial infection, inflammation, dismetabolic and degenerative disease. The concept of the chitinases involvement in human diseases discussed herein may stimulate the development of new studies leading to a deeper understanding on the biochemical mechanisms inducing chitinases regulation and on the consequences that the increases in chitinases levels impact with immunity and autoimmunity in different conditions. The future understanding on chitinase functions will lead to the opportunity to develop selective and specific chitinase inhibitors.
