Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Impact of cell death manipulation on the efficacy of photodynamic therapy-generated cancer vaccines
Mladen Korbelik, Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada
Author contributions: Korbelik M designed the described research, analyzed the data and wrote the paper.
Supported by The Canadian Cancer Society, No. # 701132.
Conflict-of-interest statement: The author has no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Mladen Korbelik, Department of Integrative Oncology, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver BC, V5Z 1L3, Canada. mkorbelik@bccrc.ca
Telephone: +1-604-6758084 Fax: +1-604-6758099
Received: May 10, 2015
Peer-review started: May 10, 2015
First decision: June 18, 2015
Revised: July 9, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: November 27, 2015
Peer-review started: May 10, 2015
First decision: June 18, 2015
Revised: July 9, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: November 27, 2015
Core Tip
Core tip: It is discussed how the mode of cell death can be important to the efficacy of cancer vaccine, using the example of photodynamic therapy-generated whole-cell vaccines. With the example of several agents modulating apoptosis, necrosis or autophagy, it is argued that the strategy of using such agents for the enhancement of the efficacy of cancer vaccines deserves serious consideration.