Gjeorgjievski M, Amin MB, Cappell MS. Characteristic clinical features of Aspergillus appendicitis: Case report and literature review. World J Gastroenterol 2015; 21(44): 12713-12721 [PMID: 26640349 DOI: 10.3748/wjg.v21.i44.12713]
Corresponding Author of This Article
Mitchell S Cappell, MD, PhD, Chief, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB #602, 3535 West Thirteen Mile Road, Royal Oak, MI 48073, United States. mscappell@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 28, 2015; 21(44): 12713-12721 Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12713
Characteristic clinical features of Aspergillus appendicitis: Case report and literature review
Mihajlo Gjeorgjievski, Mitual B Amin, Mitchell S Cappell
Mihajlo Gjeorgjievski, Mitchell S Cappell, Division of Gastroenterology and Hepatology, William Beaumont Hospital, Royal Oak, MI 48073, United States
Mitual B Amin, Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, United States
Mitual B Amin, Mitchell S Cappell, Oakland University William Beaumont School of Medicine, Royal Oak, MI 48073, United States
Author contributions: Gjeorgjievski M and Cappell MS contributed equally to the paper; Gjeorgjievski M and Cappell MS are responsible for all the clinical aspects of the paper; Amin MB contributed solely to the pathologic aspects of this paper and is responsible for this section of the paper.
Institutional review board statement: Case report exempted/approved by William Beaumont Hospital IRB on 12/01/2014.
Conflict-of-interest statement: None for all authors. This paper does not discuss any confidential pharmaceutical industry data reviewed by Dr. Cappell as a consultant for the United States Food and Drug Administration Advisory Committee on Gastrointestinal Drugs. Dr. Cappell is a member of the speaker’s bureau for AstraZeneca. This paper does not discuss any drug manufactured or marketed by AstraZeneca.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mitchell S Cappell, MD, PhD, Chief, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB #602, 3535 West Thirteen Mile Road, Royal Oak, MI 48073, United States. mscappell@yahoo.com
Telephone: +1-248-5511227 Fax: +1-248-5517581
Received: June 1, 2015 Peer-review started: June 2, 2015 First decision: June 19, 2015 Revised: July 13, 2015 Accepted: August 30, 2015 Article in press: August 31, 2015 Published online: November 28, 2015
Core Tip
Core tip: This work reports the fourth reported case of isolated Aspergillus appendicitis, further characterizes this syndrome, and identifies a clinical pentad associated with this syndrome: clinically-suspected appendicitis, neutropenia, recent chemotherapy, acute leukemia, and poor clinical course if treated solely with antibacterial or anti-Candidial antibiotics. These risk factors are biologically reasonable. Immunosuppression from neutropenia and acute leukemia may promote Aspergillus appendicitis. Local gastrointestinal ulcers from recent chemotherapy provides a nidus for fungal colonization. In patients presenting with this proposed pentad, Aspergillus appendicitis should be considered in the differential diagnosis, special silver stains should be performed to evaluate for this infection, and empiric anti-Aspergillus therapy may be considered pending tissue diagnosis.
