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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Cancer cachexia, mechanism and treatment  
Tomoyoshi Aoyagi, Krista P Terracina, Ali Raza, Hisahiro Matsubara, Kazuaki Takabe 
World J Gastrointest Oncol 7(4):17-29. Published online Apr 15, 2015. doi: 10.4251/wjgo.v7.i4.17
2
Critical evaluation of contemporary management in a new Pelvic Exenteration Unit: The first 25 consecutive cases  
Min Hoe Chew, Yu-Ting Yeh, Ee-Lin Toh, Stephen Aditya Sumarli, Ghee Kheng Chew, Lui Shiong Lee, Mann Hong Tan, Tiffany Priyanthi Hennedige, Shin Yi Ng, Say Kiat Lee, Tze Tec Chong, Hairil Rizal Abdullah, Terence Lin Hon Goh, Mohamed Zulfikar Rasheed, Kok Chai Tan, Choong Leong Tang 
World J Gastrointest Oncol 9(5):218-227. Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.218
3
Epigenetic field defects in progression to cancer  
Carol Bernstein, Valentine Nfonsam, Anil Ramarao Prasad, Harris Bernstein 
World J Gastrointest Oncol 5(3):43-49. Published online Mar 15, 2013. doi: 10.4251/wjgo.v5.i3.43
4
Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities  
Kyle J Napier, Mary Scheerer, Subhasis Misra 
World J Gastrointest Oncol 6(5):112-120. Published online May 15, 2014. doi: 10.4251/wjgo.v6.i5.112
5
Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas  
Víctor M Castellano-Megías, Carolina Ibarrola-de Andrés, Guadalupe López-Alonso, Francisco Colina-Ruizdelgado 
World J Gastrointest Oncol 6(9):311-324. Published online Sep 15, 2014. doi: 10.4251/wjgo.v6.i9.311
6
Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention  
Siddavaram Nagini 
World J Gastrointest Oncol 4(7):156-169. Published online Jul 15, 2012. doi: 10.4251/wjgo.v4.i7.156
7
Anal intraepithelial neoplasia: A review of diagnosis and management  
Joseph R Roberts, Lacey L Siekas, Andrew M Kaz 
World J Gastrointest Oncol 9(2):50-61. Published online Feb 15, 2017. doi: 10.4251/wjgo.v9.i2.50
8
Low rectal cancer: Sphincter preserving techniques-selection of patients, techniques and outcomes  
Nikoletta Dimitriou, Othon Michail, Dimitrios Moris, John Griniatsos 
World J Gastrointest Oncol 7(7):55-70. Published online Jul 15, 2015. doi: 10.4251/wjgo.v7.i7.55
9
10
Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention  
Huawei Zeng, Darina L Lazarova, Michael Bordonaro 
World J Gastrointest Oncol 6(2):41-51. Published online Feb 15, 2014. doi: 10.4251/wjgo.v6.i2.41
11
Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype  
Jeremy Stuart Williamson, Huw Geraint Jones, Namor Williams, Anthony Paul Griffiths, Gareth Jenkins, John Beynon, Dean Anthony Harris 
World J Gastrointest Oncol 9(5):209-217. Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.209
12
Severe colitis associated with docetaxel use: A report of four cases  
Andres F Carrion, Peter J Hosein, Eugene M Cooper, Gilberto Lopes, Liset Pelaez, Caio M Rocha-Lima 
World J Gastrointest Oncol 2(10):390-394. Published online Oct 15, 2010. doi: 10.4251/wjgo.v2.i10.390
13
Risk factors and classifications of hilar cholangiocarcinoma  
Miguel Angel Suarez-Munoz, Jose Luis Fernandez-Aguilar, Belinda Sanchez-Perez, Jose Antonio Perez-Daga, Beatriz Garcia-Albiach, Ysabel Pulido-Roa, Naiara Marin-Camero, Julio Santoyo-Santoyo 
World J Gastrointest Oncol 5(7):132-138. Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.132
14
Precision medicine in gastric cancer  
Patrizia Bonelli, Antonella Borrelli, Franca Maria Tuccillo, Lucrezia Silvestro, Raffaele Palaia, Franco Maria Buonaguro 
World J Gastrointest Oncol 11(10):804-829. Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.804
15
Emerging molecular targets and therapy for cholangiocarcinoma  
Hamzeh Kayhanian, Elizabeth C Smyth, Chiara Braconi 
World J Gastrointest Oncol 9(7):268-280. Published online Jul 15, 2017. doi: 10.4251/wjgo.v9.i7.268
16
Current approach in the treatment of hepatocellular carcinoma  
Luigi Rossi, Federica Zoratto, Anselmo Papa, Francesca Iodice, Marina Minozzi, Luigi Frati, Silverio Tomao 
World J Gastrointest Oncol 2(9):348-359. Published online Sep 15, 2010. doi: 10.4251/wjgo.v2.i9.348
17
Role of Helicobacter pylori in gastric cancer: Updates  
Jahanarah Khatoon, Ravi Prakash Rai, Kashi Nath Prasad 
World J Gastrointest Oncol 8(2):147-158. Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.147
18
Epigenetic reduction of DNA repair in progression to gastrointestinal cancer  
Carol Bernstein, Harris Bernstein 
World J Gastrointest Oncol 7(5):30-46. Published online May 15, 2015. doi: 10.4251/wjgo.v7.i5.30
19
Role of Raman spectroscopy and surface enhanced Raman spectroscopy in colorectal cancer  
Cerys A Jenkins, Paul D Lewis, Peter R Dunstan, Dean A Harris 
World J Gastrointest Oncol 8(5):427-438. Published online May 15, 2016. doi: 10.4251/wjgo.v8.i5.427
20
Anti program death-1/anti program death-ligand 1 in digestive cancers  
Eléonore de Guillebon, Pauline Roussille, Eric Frouin, David Tougeron 
World J Gastrointest Oncol 7(8):95-101. Published online Aug 15, 2015. doi: 10.4251/wjgo.v7.i8.95
21
Novel diet-related mouse model of colon cancer parallels human colon cancer  
Anil R Prasad, Shilpa Prasad, Huy Nguyen, Alexander Facista, Cristy Lewis, Beryl Zaitlin, Harris Bernstein, Carol Bernstein 
World J Gastrointest Oncol 6(7):225-243. Published online Jul 15, 2014. doi: 10.4251/wjgo.v6.i7.225
22
Follow-up of intestinal metaplasia in the stomach: When, how and why  
Angelo Zullo, Cesare Hassan, Adriana Romiti, Michela Giusto, Carmine Guerriero, Roberto Lorenzetti, Salvatore MA Campo, Silverio Tomao 
World J Gastrointest Oncol 4(3):30-36. Published online Mar 15, 2012. doi: 10.4251/wjgo.v4.i3.30
23
Radiological diagnosis and staging of hilar cholangiocarcinoma  
Carlos Valls, Sandra Ruiz, Laura Martinez, David Leiva 
World J Gastrointest Oncol 5(7):115-126. Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.115
24
Autophagy in colorectal cancer: An important switch from physiology to pathology  
Florin Burada, Elena Raluca Nicoli, Marius Eugen Ciurea, Daniel Constantin Uscatu, Mihai Ioana, Dan Ionut Gheonea 
World J Gastrointest Oncol 7(11):271-284. Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.271
25
Outcome of curative resection for perihilar cholangiocarcinoma in Northeast Thailand  
Attapol Titapun, Ake Pugkhem, Vor Luvira, Tharatip Srisuk, Ongart Somintara, O-tur Saeseow, Anan Sripanuskul, Anongporn Nimboriboonporn, Bandit Thinkhamrop, Narong Khuntikeo 
World J Gastrointest Oncol 7(12):503-512. Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.503
26
Esophageal cancer management controversies: Radiation oncology point of view  
Patricia Tai, Edward Yu 
World J Gastrointest Oncol 6(8):263-274. Published online Aug 15, 2014. doi: 10.4251/wjgo.v6.i8.263
27
Role of retinoids in the prevention and treatment of colorectal cancer  
Catherine C Applegate, Michelle A Lane 
World J Gastrointest Oncol 7(10):184-203. Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.184
28
A gist of gastrointestinal stromal tumors: A review  
Ashwin Rammohan, Jeswanth Sathyanesan, Kamalakannan Rajendran, Anbalagan Pitchaimuthu, Senthil-Kumar Perumal, UP Srinivasan, Ravi Ramasamy, Ravichandran Palaniappan, Manoharan Govindan 
World J Gastrointest Oncol 5(6):102-112. Published online Jun 15, 2013. doi: 10.4251/wjgo.v5.i6.102
29
Pathological aspects of so called "hilar cholangiocarcinoma"  
Víctor M Castellano-Megías, Carolina Ibarrola-de Andrés, Francisco Colina-Ruizdelgado 
World J Gastrointest Oncol 5(7):159-170. Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.159
30
Regulation of CTNNB1 signaling in gastric cancer and stem cells  
Shihori Tanabe, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki 
World J Gastrointest Oncol 8(8):592-598. Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.592
31
Selection of patients and staging of peritoneal surface malignancies  
Eddy Cotte, Guillaume Passot, François-Noël Gilly, Olivier Glehen 
World J Gastrointest Oncol 2(1):31-35. Published online Jan 15, 2010. doi: 10.4251/wjgo.v2.i1.31
32
Role of targeted therapy in metastatic colorectal cancer  
Yoshihito Ohhara, Naoki Fukuda, Satoshi Takeuchi, Rio Honma, Yasushi Shimizu, Ichiro Kinoshita, Hirotoshi Dosaka-Akita 
World J Gastrointest Oncol 8(9):642-655. Published online Sep 15, 2016. doi: 10.4251/wjgo.v8.i9.642
33
Introduction of laparoscopic gastrectomy for gastric cancer in a Western tertiary referral centre: A prospective cost analysis during the learning curve  
Juul J Tegels, Charlotte E Silvius, Frederique E Spauwen, Karel W Hulsewé, Anton G Hoofwijk, Jan H Stoot 
World J Gastrointest Oncol 9(5):228-234. Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.228
34
Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer  
Ganepola AP Ganepola, Joel Nizin, John R Rutledge, David H Chang 
World J Gastrointest Oncol 6(4):83-97. Published online Apr 15, 2014. doi: 10.4251/wjgo.v6.i4.83
35
Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes  
Hironori Yamaguchi, Joji Kitayama, Hironori Ishigami, Shinsuke Kazama, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Junichiro Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Soichiro Ishihara, Eiji Sunami, Toshiaki Watanabe 
World J Gastrointest Oncol 7(11):285-291. Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.285
36
On the road to standardization of D2 lymph node dissection in a European population of patients with gastric cancer  
Roman Yarema, Giovanni de Manzoni, Taras Fetsych, Myron Ohorchak, Mykhailo Pliatsko, Maria Bencivenga 
World J Gastrointest Oncol 8(6):489-497. Published online Jun 15, 2016. doi: 10.4251/wjgo.v8.i6.489
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40
Tricks and tips in pancreatoduodenectomy  
Anna Pallisera, Rafael Morales, Jose Manuel Ramia 
World J Gastrointest Oncol 6(9):344-350. Published online Sep 15, 2014. doi: 10.4251/wjgo.v6.i9.344
41
Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer  
Ganepola AP Ganepola, John R Rutledge, Paritosh Suman, Anusak Yiengpruksawan, David H Chang 
World J Gastrointest Oncol 6(1):22-33. Published online Jan 15, 2014. doi: 10.4251/wjgo.v6.i1.22
42
Intestinal lymphangiectasia in adults  
Hugh James Freeman, Michael Nimmo 
World J Gastrointest Oncol 3(2):19-23. Published online Feb 15, 2011. doi: 10.4251/wjgo.v3.i2.19
43
Gastric peritoneal carcinomatosis - a retrospective review  
Hwee Leong Tan, Claramae Shulyn Chia, Grace Hwei Ching Tan, Su Pin Choo, David Wai-Meng Tai, Clarinda Wei Ling Chua, Matthew Chau Hsien Ng, Khee Chee Soo, Melissa Ching Ching Teo 
World J Gastrointest Oncol 9(3):121-128. Published online Mar 15, 2017. doi: 10.4251/wjgo.v9.i3.121
44
Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives  
Roberta Gaziano, Gabriella Moroni, Cristina Buè, Martino Tony Miele, Paola Sinibaldi-Vallebona, Francesca Pica 
World J Gastrointest Oncol 8(1):30-39. Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.30
45
Locoregional therapy and systemic cetuximab to treat colorectal liver metastases  
Giammaria Fiorentini, Camillo Aliberti, Donatella Sarti, Paolo Coschiera, Massimo Tilli, Luca Mulazzani, Paolo Giordani, Francesco Graziano, Alfonso Marqués Gonzalez, Raul García Marcos, Fernando Gómez Mugnoz, Maurizio Cantore, Stefano Ricci, Vincenzo Catalano, Andrea Mambrini 
World J Gastrointest Oncol 7(6):47-54. Published online Jun 15, 2015. doi: 10.4251/wjgo.v7.i6.47
46
Can molecular biomarkers replace a clinical risk score for resectable colorectal liver metastasis?  
Torhild Veen, Kjetil Søreide 
World J Gastrointest Oncol 9(3):98-104. Published online Mar 15, 2017. doi: 10.4251/wjgo.v9.i3.98
47
Ampullary cancer of intestinal origin and duodenal cancer - A logical clinical and therapeutic subgroup in periampullary cancer  
Manju D Chandrasegaram, Anthony J Gill, Jas Samra, Tim Price, John Chen, Jonathan Fawcett, Neil D Merrett 
World J Gastrointest Oncol 9(10):407-415. Published online Oct 15, 2017. doi: 10.4251/wjgo.v9.i10.407
48
MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions  
Yasmin G Hernandez, Aimee L Lucas 
World J Gastrointest Oncol 8(1):18-29. Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.18
49
Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy  
Eckhard Klieser, Stefan Swierczynski, Christian Mayr, Johanna Schmidt, Daniel Neureiter, Tobias Kiesslich, Romana Illig 
World J Gastrointest Oncol 7(12):473-483. Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.473
50
Pseudomyxoma peritonei  
Katharine E Bevan, Faheez Mohamed, Brendan J Moran 
World J Gastrointest Oncol 2(1):44-50. Published online Jan 15, 2010. doi: 10.4251/wjgo.v2.i1.44