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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Cancer cachexia, mechanism and treatment  
Tomoyoshi Aoyagi, Krista P Terracina, Ali Raza, Hisahiro Matsubara, Kazuaki Takabe 
World J Gastrointest Oncol 7(4):17-29. Published online Apr 15, 2015. doi: 10.4251/wjgo.v7.i4.17
2
Critical evaluation of contemporary management in a new Pelvic Exenteration Unit: The first 25 consecutive cases  
Min Hoe Chew, Yu-Ting Yeh, Ee-Lin Toh, Stephen Aditya Sumarli, Ghee Kheng Chew, Lui Shiong Lee, Mann Hong Tan, Tiffany Priyanthi Hennedige, Shin Yi Ng, Say Kiat Lee, Tze Tec Chong, Hairil Rizal Abdullah, Terence Lin Hon Goh, Mohamed Zulfikar Rasheed, Kok Chai Tan, Choong Leong Tang 
World J Gastrointest Oncol 9(5):218-227. Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.218
3
Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas  
Víctor M Castellano-Megías, Carolina Ibarrola-de Andrés, Guadalupe López-Alonso, Francisco Colina-Ruizdelgado 
World J Gastrointest Oncol 6(9):311-324. Published online Sep 15, 2014. doi: 10.4251/wjgo.v6.i9.311
4
Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention  
Siddavaram Nagini 
World J Gastrointest Oncol 4(7):156-169. Published online Jul 15, 2012. doi: 10.4251/wjgo.v4.i7.156
5
Epigenetic field defects in progression to cancer  
Carol Bernstein, Valentine Nfonsam, Anil Ramarao Prasad, Harris Bernstein 
World J Gastrointest Oncol 5(3):43-49. Published online Mar 15, 2013. doi: 10.4251/wjgo.v5.i3.43
6
Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities  
Kyle J Napier, Mary Scheerer, Subhasis Misra 
World J Gastrointest Oncol 6(5):112-120. Published online May 15, 2014. doi: 10.4251/wjgo.v6.i5.112
7
Low rectal cancer: Sphincter preserving techniques-selection of patients, techniques and outcomes  
Nikoletta Dimitriou, Othon Michail, Dimitrios Moris, John Griniatsos 
World J Gastrointest Oncol 7(7):55-70. Published online Jul 15, 2015. doi: 10.4251/wjgo.v7.i7.55
8
Anal intraepithelial neoplasia: A review of diagnosis and management  
Joseph R Roberts, Lacey L Siekas, Andrew M Kaz 
World J Gastrointest Oncol 9(2):50-61. Published online Feb 15, 2017. doi: 10.4251/wjgo.v9.i2.50
9
Severe colitis associated with docetaxel use: A report of four cases  
Andres F Carrion, Peter J Hosein, Eugene M Cooper, Gilberto Lopes, Liset Pelaez, Caio M Rocha-Lima 
World J Gastrointest Oncol 2(10):390-394. Published online Oct 15, 2010. doi: 10.4251/wjgo.v2.i10.390
10
Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention  
Huawei Zeng, Darina L Lazarova, Michael Bordonaro 
World J Gastrointest Oncol 6(2):41-51. Published online Feb 15, 2014. doi: 10.4251/wjgo.v6.i2.41
11
Current approach in the treatment of hepatocellular carcinoma  
Luigi Rossi, Federica Zoratto, Anselmo Papa, Francesca Iodice, Marina Minozzi, Luigi Frati, Silverio Tomao 
World J Gastrointest Oncol 2(9):348-359. Published online Sep 15, 2010. doi: 10.4251/wjgo.v2.i9.348
12
Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype  
Jeremy Stuart Williamson, Huw Geraint Jones, Namor Williams, Anthony Paul Griffiths, Gareth Jenkins, John Beynon, Dean Anthony Harris 
World J Gastrointest Oncol 9(5):209-217. Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.209
13
14
Risk factors and classifications of hilar cholangiocarcinoma  
Miguel Angel Suarez-Munoz, Jose Luis Fernandez-Aguilar, Belinda Sanchez-Perez, Jose Antonio Perez-Daga, Beatriz Garcia-Albiach, Ysabel Pulido-Roa, Naiara Marin-Camero, Julio Santoyo-Santoyo 
World J Gastrointest Oncol 5(7):132-138. Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.132
15
Role of Helicobacter pylori in gastric cancer: Updates  
Jahanarah Khatoon, Ravi Prakash Rai, Kashi Nath Prasad 
World J Gastrointest Oncol 8(2):147-158. Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.147
16
Anti program death-1/anti program death-ligand 1 in digestive cancers  
Eléonore de Guillebon, Pauline Roussille, Eric Frouin, David Tougeron 
World J Gastrointest Oncol 7(8):95-101. Published online Aug 15, 2015. doi: 10.4251/wjgo.v7.i8.95
17
Role of Raman spectroscopy and surface enhanced Raman spectroscopy in colorectal cancer  
Cerys A Jenkins, Paul D Lewis, Peter R Dunstan, Dean A Harris 
World J Gastrointest Oncol 8(5):427-438. Published online May 15, 2016. doi: 10.4251/wjgo.v8.i5.427
18
Novel diet-related mouse model of colon cancer parallels human colon cancer  
Anil R Prasad, Shilpa Prasad, Huy Nguyen, Alexander Facista, Cristy Lewis, Beryl Zaitlin, Harris Bernstein, Carol Bernstein 
World J Gastrointest Oncol 6(7):225-243. Published online Jul 15, 2014. doi: 10.4251/wjgo.v6.i7.225
19
Esophageal cancer management controversies: Radiation oncology point of view  
Patricia Tai, Edward Yu 
World J Gastrointest Oncol 6(8):263-274. Published online Aug 15, 2014. doi: 10.4251/wjgo.v6.i8.263
20
Epigenetic reduction of DNA repair in progression to gastrointestinal cancer  
Carol Bernstein, Harris Bernstein 
World J Gastrointest Oncol 7(5):30-46. Published online May 15, 2015. doi: 10.4251/wjgo.v7.i5.30
21
Regulation of CTNNB1 signaling in gastric cancer and stem cells  
Shihori Tanabe, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki 
World J Gastrointest Oncol 8(8):592-598. Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.592
22
Role of targeted therapy in metastatic colorectal cancer  
Yoshihito Ohhara, Naoki Fukuda, Satoshi Takeuchi, Rio Honma, Yasushi Shimizu, Ichiro Kinoshita, Hirotoshi Dosaka-Akita 
World J Gastrointest Oncol 8(9):642-655. Published online Sep 15, 2016. doi: 10.4251/wjgo.v8.i9.642
23
24
Introduction of laparoscopic gastrectomy for gastric cancer in a Western tertiary referral centre: A prospective cost analysis during the learning curve  
Juul J Tegels, Charlotte E Silvius, Frederique E Spauwen, Karel W Hulsewé, Anton G Hoofwijk, Jan H Stoot 
World J Gastrointest Oncol 9(5):228-234. Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.228
25
Intestinal lymphangiectasia in adults  
Hugh James Freeman, Michael Nimmo 
World J Gastrointest Oncol 3(2):19-23. Published online Feb 15, 2011. doi: 10.4251/wjgo.v3.i2.19
26
27
On the road to standardization of D2 lymph node dissection in a European population of patients with gastric cancer  
Roman Yarema, Giovanni de Manzoni, Taras Fetsych, Myron Ohorchak, Mykhailo Pliatsko, Maria Bencivenga 
World J Gastrointest Oncol 8(6):489-497. Published online Jun 15, 2016. doi: 10.4251/wjgo.v8.i6.489
28
Outcome of curative resection for perihilar cholangiocarcinoma in Northeast Thailand  
Attapol Titapun, Ake Pugkhem, Vor Luvira, Tharatip Srisuk, Ongart Somintara, O-tur Saeseow, Anan Sripanuskul, Anongporn Nimboriboonporn, Bandit Thinkhamrop, Narong Khuntikeo 
World J Gastrointest Oncol 7(12):503-512. Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.503
29
Role of retinoids in the prevention and treatment of colorectal cancer  
Catherine C Applegate, Michelle A Lane 
World J Gastrointest Oncol 7(10):184-203. Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.184
30
Selection of patients and staging of peritoneal surface malignancies  
Eddy Cotte, Guillaume Passot, François-Noël Gilly, Olivier Glehen 
World J Gastrointest Oncol 2(1):31-35. Published online Jan 15, 2010. doi: 10.4251/wjgo.v2.i1.31
31
A gist of gastrointestinal stromal tumors: A review  
Ashwin Rammohan, Jeswanth Sathyanesan, Kamalakannan Rajendran, Anbalagan Pitchaimuthu, Senthil-Kumar Perumal, UP Srinivasan, Ravi Ramasamy, Ravichandran Palaniappan, Manoharan Govindan 
World J Gastrointest Oncol 5(6):102-112. Published online Jun 15, 2013. doi: 10.4251/wjgo.v5.i6.102
32
Pathological aspects of so called "hilar cholangiocarcinoma"  
Víctor M Castellano-Megías, Carolina Ibarrola-de Andrés, Francisco Colina-Ruizdelgado 
World J Gastrointest Oncol 5(7):159-170. Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.159
33
Molecular mechanisms of chemoresistance in gastric cancer  
Wen-Jia Shi, Jin-Bo Gao 
World J Gastrointest Oncol 8(9):673-681. Published online Sep 15, 2016. doi: 10.4251/wjgo.v8.i9.673
34
Locoregional therapy and systemic cetuximab to treat colorectal liver metastases  
Giammaria Fiorentini, Camillo Aliberti, Donatella Sarti, Paolo Coschiera, Massimo Tilli, Luca Mulazzani, Paolo Giordani, Francesco Graziano, Alfonso Marqués Gonzalez, Raul García Marcos, Fernando Gómez Mugnoz, Maurizio Cantore, Stefano Ricci, Vincenzo Catalano, Andrea Mambrini 
World J Gastrointest Oncol 7(6):47-54. Published online Jun 15, 2015. doi: 10.4251/wjgo.v7.i6.47
35
Autophagy in colorectal cancer: An important switch from physiology to pathology  
Florin Burada, Elena Raluca Nicoli, Marius Eugen Ciurea, Daniel Constantin Uscatu, Mihai Ioana, Dan Ionut Gheonea 
World J Gastrointest Oncol 7(11):271-284. Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.271
36
Radiological diagnosis and staging of hilar cholangiocarcinoma  
Carlos Valls, Sandra Ruiz, Laura Martinez, David Leiva 
World J Gastrointest Oncol 5(7):115-126. Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.115
37
Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes  
Hironori Yamaguchi, Joji Kitayama, Hironori Ishigami, Shinsuke Kazama, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Junichiro Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Soichiro Ishihara, Eiji Sunami, Toshiaki Watanabe 
World J Gastrointest Oncol 7(11):285-291. Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.285
38
Follow-up of intestinal metaplasia in the stomach: When, how and why  
Angelo Zullo, Cesare Hassan, Adriana Romiti, Michela Giusto, Carmine Guerriero, Roberto Lorenzetti, Salvatore MA Campo, Silverio Tomao 
World J Gastrointest Oncol 4(3):30-36. Published online Mar 15, 2012. doi: 10.4251/wjgo.v4.i3.30
39
Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy  
Eckhard Klieser, Stefan Swierczynski, Christian Mayr, Johanna Schmidt, Daniel Neureiter, Tobias Kiesslich, Romana Illig 
World J Gastrointest Oncol 7(12):473-483. Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.473
40
Pseudomyxoma peritonei  
Katharine E Bevan, Faheez Mohamed, Brendan J Moran 
World J Gastrointest Oncol 2(1):44-50. Published online Jan 15, 2010. doi: 10.4251/wjgo.v2.i1.44
41
Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer  
Ganepola AP Ganepola, John R Rutledge, Paritosh Suman, Anusak Yiengpruksawan, David H Chang 
World J Gastrointest Oncol 6(1):22-33. Published online Jan 15, 2014. doi: 10.4251/wjgo.v6.i1.22
42
Hyperthermic intraperitoneal chemotherapy: Rationale and technique  
Santiago González-Moreno, Luis A González-Bayón, Gloria Ortega-Pérez 
World J Gastrointest Oncol 2(2):68-75. Published online Feb 15, 2010. doi: 10.4251/wjgo.v2.i2.68
43
Gastric peritoneal carcinomatosis - a retrospective review  
Hwee Leong Tan, Claramae Shulyn Chia, Grace Hwei Ching Tan, Su Pin Choo, David Wai-Meng Tai, Clarinda Wei Ling Chua, Matthew Chau Hsien Ng, Khee Chee Soo, Melissa Ching Ching Teo 
World J Gastrointest Oncol 9(3):121-128. Published online Mar 15, 2017. doi: 10.4251/wjgo.v9.i3.121
44
Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives  
Roberta Gaziano, Gabriella Moroni, Cristina Buè, Martino Tony Miele, Paola Sinibaldi-Vallebona, Francesca Pica 
World J Gastrointest Oncol 8(1):30-39. Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.30
45
MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions  
Yasmin G Hernandez, Aimee L Lucas 
World J Gastrointest Oncol 8(1):18-29. Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.18
46
Can molecular biomarkers replace a clinical risk score for resectable colorectal liver metastasis?  
Torhild Veen, Kjetil Søreide 
World J Gastrointest Oncol 9(3):98-104. Published online Mar 15, 2017. doi: 10.4251/wjgo.v9.i3.98
47
Tricks and tips in pancreatoduodenectomy  
Anna Pallisera, Rafael Morales, Jose Manuel Ramia 
World J Gastrointest Oncol 6(9):344-350. Published online Sep 15, 2014. doi: 10.4251/wjgo.v6.i9.344
48
Usefulness of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of hepatic, gallbladder and biliary tract Lesions  
Ghassan M Hammoud, Ashraf Almashhrawi, Jamal A Ibdah 
World J Gastrointest Oncol 6(11):420-429. Published online Nov 15, 2014. doi: 10.4251/wjgo.v6.i11.420
49
Academic hospital staff compliance with a fecal immunochemical test-based colorectal cancer screening program  
Georgia Vlachonikolou, Paraskevas Gkolfakis, Athanasios D Sioulas, Ioannis S Papanikolaou, Anastasia Melissaratou, Giannis-Aimant Moustafa, Eleni Xanthopoulou, Gerasimos Tsilimidos, Ioanna Tsironi, Paraskevas Filippidis, Chrysoula Malli, George D Dimitriadis, Konstantinos Triantafyllou 
World J Gastrointest Oncol 8(8):629-634. Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.629
50
Targeting inflammation in pancreatic cancer: Clinical translation  
Colin William Steele, Nina Angharad Kaur Gill, Nigel Balfour Jamieson, Christopher Ross Carter 
World J Gastrointest Oncol 8(4):380-388. Published online Apr 15, 2016. doi: 10.4251/wjgo.v8.i4.380