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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Cancer cachexia, mechanism and treatment  
Tomoyoshi Aoyagi, Krista P Terracina, Ali Raza, Hisahiro Matsubara, Kazuaki Takabe 
World J Gastrointest Oncol 7(4):17-29. Published online Apr 15, 2015. doi: 10.4251/wjgo.v7.i4.17
2
Precision medicine in gastric cancer  
Patrizia Bonelli, Antonella Borrelli, Franca Maria Tuccillo, Lucrezia Silvestro, Raffaele Palaia, Franco Maria Buonaguro 
World J Gastrointest Oncol 11(10):804-829. Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.804
3
Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities  
Kyle J Napier, Mary Scheerer, Subhasis Misra 
World J Gastrointest Oncol 6(5):112-120. Published online May 15, 2014. doi: 10.4251/wjgo.v6.i5.112
4
5
Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy  
Panagiotis Sarantis, Evangelos Koustas, Adriana Papadimitropoulou, Athanasios G Papavassiliou, Michalis V Karamouzis 
World J Gastrointest Oncol 12(2):173-181. Published online Feb 15, 2020. doi: 10.4251/wjgo.v12.i2.173
6
Critical evaluation of contemporary management in a new Pelvic Exenteration Unit: The first 25 consecutive cases  
Min Hoe Chew, Yu-Ting Yeh, Ee-Lin Toh, Stephen Aditya Sumarli, Ghee Kheng Chew, Lui Shiong Lee, Mann Hong Tan, Tiffany Priyanthi Hennedige, Shin Yi Ng, Say Kiat Lee, Tze Tec Chong, Hairil Rizal Abdullah, Terence Lin Hon Goh, Mohamed Zulfikar Rasheed, Kok Chai Tan, Choong Leong Tang 
World J Gastrointest Oncol 9(5):218-227. Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.218
7
Anal intraepithelial neoplasia: A review of diagnosis and management  
Joseph R Roberts, Lacey L Siekas, Andrew M Kaz 
World J Gastrointest Oncol 9(2):50-61. Published online Feb 15, 2017. doi: 10.4251/wjgo.v9.i2.50
8
Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention  
Siddavaram Nagini 
World J Gastrointest Oncol 4(7):156-169. Published online Jul 15, 2012. doi: 10.4251/wjgo.v4.i7.156
9
Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas  
Víctor M Castellano-Megías, Carolina Ibarrola-de Andrés, Guadalupe López-Alonso, Francisco Colina-Ruizdelgado 
World J Gastrointest Oncol 6(9):311-324. Published online Sep 15, 2014. doi: 10.4251/wjgo.v6.i9.311
10
Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention  
Huawei Zeng, Darina L Lazarova, Michael Bordonaro 
World J Gastrointest Oncol 6(2):41-51. Published online Feb 15, 2014. doi: 10.4251/wjgo.v6.i2.41
11
12
Low rectal cancer: Sphincter preserving techniques-selection of patients, techniques and outcomes  
Nikoletta Dimitriou, Othon Michail, Dimitrios Moris, John Griniatsos 
World J Gastrointest Oncol 7(7):55-70. Published online Jul 15, 2015. doi: 10.4251/wjgo.v7.i7.55
13
Effect of exercise on colorectal cancer prevention and treatment  
Zeynep Oruç, Muhammed Ali Kaplan 
World J Gastrointest Oncol 11(5):348-366. Published online May 15, 2019. doi: 10.4251/wjgo.v11.i5.348
14
Caffeine and its main targets of colorectal cancer  
Wen-Qi Cui, Shi-Tong Wang, Dan Pan, Bing Chang, Li-Xuan Sang 
World J Gastrointest Oncol 12(2):149-172. Published online Feb 15, 2020. doi: 10.4251/wjgo.v12.i2.149
15
Epigenetic field defects in progression to cancer  
Carol Bernstein, Valentine Nfonsam, Anil Ramarao Prasad, Harris Bernstein 
World J Gastrointest Oncol 5(3):43-49. Published online Mar 15, 2013. doi: 10.4251/wjgo.v5.i3.43
16
Precision medicine for gastrointestinal cancer: Recent progress and future perspective  
Tasuku Matsuoka, Masakazu Yashiro 
World J Gastrointest Oncol 12(1):1-20. Published online Jan 15, 2020. doi: 10.4251/wjgo.v12.i1.1
17
Prognostic significance of perioperative tumor marker levels in stage II/III gastric cancer  
Yasuhito Suenaga, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera 
World J Gastrointest Oncol 11(1):17-27. Published online Jan 15, 2019. doi: 10.4251/wjgo.v11.i1.17
18
Role of Helicobacter pylori in gastric cancer: Updates  
Jahanarah Khatoon, Ravi Prakash Rai, Kashi Nath Prasad 
World J Gastrointest Oncol 8(2):147-158. Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.147
19
Biomarkers for detecting colorectal cancer non-invasively: DNA, RNA or proteins?  
Alexandre Loktionov 
World J Gastrointest Oncol 12(2):124-148. Published online Feb 15, 2020. doi: 10.4251/wjgo.v12.i2.124
20
Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review  
Ashok kumar Pandurangan, Thomas Divya, Kalaivani Kumar, Vadivel Dineshbabu, Bakthavatchalam Velavan, Ganapasam Sudhandiran 
World J Gastrointest Oncol 10(9):244-259. Published online Sep 15, 2018. doi: 10.4251/wjgo.v10.i9.244
21
Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype  
Jeremy Stuart Williamson, Huw Geraint Jones, Namor Williams, Anthony Paul Griffiths, Gareth Jenkins, John Beynon, Dean Anthony Harris 
World J Gastrointest Oncol 9(5):209-217. Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.209
22
Follow-up of intestinal metaplasia in the stomach: When, how and why  
Angelo Zullo, Cesare Hassan, Adriana Romiti, Michela Giusto, Carmine Guerriero, Roberto Lorenzetti, Salvatore MA Campo, Silverio Tomao 
World J Gastrointest Oncol 4(3):30-36. Published online Mar 15, 2012. doi: 10.4251/wjgo.v4.i3.30
23
Autophagy in colorectal cancer: An important switch from physiology to pathology  
Florin Burada, Elena Raluca Nicoli, Marius Eugen Ciurea, Daniel Constantin Uscatu, Mihai Ioana, Dan Ionut Gheonea 
World J Gastrointest Oncol 7(11):271-284. Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.271
24
Clinical diagnosis and management of pancreatic mucinous cystadenoma and cystadenocarcinoma: Single-center experience with 82 patients  
Zhi-Ming Zhao, Nan Jiang, Yuan-Xing Gao, Zhu-Zeng Yin, Guo-Dong Zhao, Xiang-Long Tan, Yong Xu, Rong Liu 
World J Gastrointest Oncol 12(6):642-650. Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.642
25
Ampulla of Vater carcinoma: Molecular landscape and clinical implications  
Antonio Pea, Giulio Riva, Riccardo Bernasconi, Elisabetta Sereni, Rita Teresa Lawlor, Aldo Scarpa, Claudio Luchini 
World J Gastrointest Oncol 10(11):370-380. Published online Nov 15, 2018. doi: 10.4251/wjgo.v10.i11.370
26
Gastric neuroendocrine tumor: A practical literature review  
Gabriel Antonio Roberto, Carolina Magalhães Britto Rodrigues, Renata D’Alpino Peixoto, Riad Naim Younes 
World J Gastrointest Oncol 12(8):850-856. Published online Aug 15, 2020. doi: 10.4251/wjgo.v12.i8.850
27
Sessile serrated adenoma detection rate is correlated with adenoma detection rate  
Daisuke Ohki, Yosuke Tsuji, Tomohiro Shinozaki, Yoshiki Sakaguchi, Chihiro Minatsuki, Hiroto Kinoshita, Keiko Niimi, Satoshi Ono, Yoku Hayakawa, Shuntaro Yoshida, Atsuo Yamada, Shinya Kodashima, Nobutake Yamamichi, Yoshihiro Hirata, Tetsuo Ushiku, Mitsuhiro Fujishiro, Masashi Fukayama, Kazuhiko Koike 
World J Gastrointest Oncol 10(3):82-90. Published online Mar 15, 2018. doi: 10.4251/wjgo.v10.i3.82
28
Role of Raman spectroscopy and surface enhanced Raman spectroscopy in colorectal cancer  
Cerys A Jenkins, Paul D Lewis, Peter R Dunstan, Dean A Harris 
World J Gastrointest Oncol 8(5):427-438. Published online May 15, 2016. doi: 10.4251/wjgo.v8.i5.427
29
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model  
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W LeBaron 
World J Gastrointest Oncol 14(1):242-252. Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.242
30
Epigenetic reduction of DNA repair in progression to gastrointestinal cancer  
Carol Bernstein, Harris Bernstein 
World J Gastrointest Oncol 7(5):30-46. Published online May 15, 2015. doi: 10.4251/wjgo.v7.i5.30
31
Emerging molecular targets and therapy for cholangiocarcinoma  
Hamzeh Kayhanian, Elizabeth C Smyth, Chiara Braconi 
World J Gastrointest Oncol 9(7):268-280. Published online Jul 15, 2017. doi: 10.4251/wjgo.v9.i7.268
32
Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from non-neoplasia for colorectal diminutive polyps (≤ 5 mm)  
Takahiro Utsumi, Yasushi Sano, Mineo Iwatate, Hironori Sunakawa, Akira Teramoto, Daizen Hirata, Santa Hattori, Wataru Sano, Noriaki Hasuike, Kazuhito Ichikawa, Takahiro Fujimori 
World J Gastrointest Oncol 10(4):96-102. Published online Apr 15, 2018. doi: 10.4251/wjgo.v10.i4.96
33
FOLFIRINOX vs gemcitabine/nab-paclitaxel for treatment of metastatic pancreatic cancer: Single-center cohort study  
In Rae Cho, Huapyong Kang, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Chansik An, Mi-Suk Park, Seungmin Bang 
World J Gastrointest Oncol 12(2):182-194. Published online Feb 15, 2020. doi: 10.4251/wjgo.v12.i2.182
34
Novel diet-related mouse model of colon cancer parallels human colon cancer  
Anil R Prasad, Shilpa Prasad, Huy Nguyen, Alexander Facista, Cristy Lewis, Beryl Zaitlin, Harris Bernstein, Carol Bernstein 
World J Gastrointest Oncol 6(7):225-243. Published online Jul 15, 2014. doi: 10.4251/wjgo.v6.i7.225
35
Radiological diagnosis and staging of hilar cholangiocarcinoma  
Carlos Valls, Sandra Ruiz, Laura Martinez, David Leiva 
World J Gastrointest Oncol 5(7):115-126. Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.115
36
Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice  
Alexander JP Fulton, Angela Lamarca, Christina Nuttall, Lynne McCallum, Rille Pihlak, Derek O’Reilly, Fiona Lalloo, Mairéad G McNamara, Richard A Hubner, Tara Clancy, Juan W Valle 
World J Gastrointest Oncol 11(2):102-116. Published online Feb 15, 2019. doi: 10.4251/wjgo.v11.i2.102
37
Severe colitis associated with docetaxel use: A report of four cases  
Andres F Carrion, Peter J Hosein, Eugene M Cooper, Gilberto Lopes, Liset Pelaez, Caio M Rocha-Lima 
World J Gastrointest Oncol 2(10):390-394. Published online Oct 15, 2010. doi: 10.4251/wjgo.v2.i10.390
38
Significance of HER2 protein expression and HER2 gene amplification in colorectal adenocarcinomas  
Xin-Yu Wang, Zhi-Xue Zheng, Yu Sun, Yan-Hua Bai, Yun-Fei Shi, Li-Xin Zhou, Yun-Feng Yao, Ai-Wen Wu, Deng-Feng Cao 
World J Gastrointest Oncol 11(4):335-347. Published online Apr 15, 2019. doi: 10.4251/wjgo.v11.i4.335
39
Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis  
Cheng-Yu Hung, Ta-Sen Yeh, Cheng-Kun Tsai, Ren-Chin Wu, Ying-Chieh Lai, Meng-Han Chiang, Kuan-Ying Lu, Chia-Ni Lin, Mei-Ling Cheng, Gigin Lin 
World J Gastrointest Oncol 11(3):181-194. Published online Mar 15, 2019. doi: 10.4251/wjgo.v11.i3.181
40
Laparoscopic and endoscopic cooperative surgery for gastric tumors: Perspective for actual practice and oncological benefits  
Yuki Aisu, Daiki Yasukawa, Yusuke Kimura, Tomohide Hori 
World J Gastrointest Oncol 10(11):381-397. Published online Nov 15, 2018. doi: 10.4251/wjgo.v10.i11.381
41
Outcome of curative resection for perihilar cholangiocarcinoma in Northeast Thailand  
Attapol Titapun, Ake Pugkhem, Vor Luvira, Tharatip Srisuk, Ongart Somintara, O-tur Saeseow, Anan Sripanuskul, Anongporn Nimboriboonporn, Bandit Thinkhamrop, Narong Khuntikeo 
World J Gastrointest Oncol 7(12):503-512. Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.503
42
Hepatic Hemangioendothelioma: An update  
Mayur Virarkar, Mohammed Saleh, Radwan Diab, Melissa Taggart, Peeyush Bhargava, Priya Bhosale 
World J Gastrointest Oncol 12(3):248-266. Published online Mar 15, 2020. doi: 10.4251/wjgo.v12.i3.248
43
Radiology of pancreatic neoplasms: An update  
Luis Gijón de la Santa, José Antonio Pérez Retortillo, Ainhoa Camarero Miguel, Lea Marie Klein 
World J Gastrointest Oncol 6(9):330-343. Published online Sep 15, 2014. doi: 10.4251/wjgo.v6.i9.330
44
Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes  
Hironori Yamaguchi, Joji Kitayama, Hironori Ishigami, Shinsuke Kazama, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Junichiro Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Soichiro Ishihara, Eiji Sunami, Toshiaki Watanabe 
World J Gastrointest Oncol 7(11):285-291. Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.285
45
Risk factors and classifications of hilar cholangiocarcinoma  
Miguel Angel Suarez-Munoz, Jose Luis Fernandez-Aguilar, Belinda Sanchez-Perez, Jose Antonio Perez-Daga, Beatriz Garcia-Albiach, Ysabel Pulido-Roa, Naiara Marin-Camero, Julio Santoyo-Santoyo 
World J Gastrointest Oncol 5(7):132-138. Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.132
46
Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives  
Roberta Gaziano, Gabriella Moroni, Cristina Buè, Martino Tony Miele, Paola Sinibaldi-Vallebona, Francesca Pica 
World J Gastrointest Oncol 8(1):30-39. Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.30
47
Role of targeted therapy in metastatic colorectal cancer  
Yoshihito Ohhara, Naoki Fukuda, Satoshi Takeuchi, Rio Honma, Yasushi Shimizu, Ichiro Kinoshita, Hirotoshi Dosaka-Akita 
World J Gastrointest Oncol 8(9):642-655. Published online Sep 15, 2016. doi: 10.4251/wjgo.v8.i9.642
48
Ampullary cancer of intestinal origin and duodenal cancer - A logical clinical and therapeutic subgroup in periampullary cancer  
Manju D Chandrasegaram, Anthony J Gill, Jas Samra, Tim Price, John Chen, Jonathan Fawcett, Neil D Merrett 
World J Gastrointest Oncol 9(10):407-415. Published online Oct 15, 2017. doi: 10.4251/wjgo.v9.i10.407
49
Utilizing gastric cancer organoids to assess tumor biology and personalize medicine  
Miranda Lin, Mei Gao, Michael J Cavnar, Joseph Kim 
World J Gastrointest Oncol 11(7):509-517. Published online Jul 15, 2019. doi: 10.4251/wjgo.v11.i7.509
50
Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer  
Ganepola AP Ganepola, John R Rutledge, Paritosh Suman, Anusak Yiengpruksawan, David H Chang 
World J Gastrointest Oncol 6(1):22-33. Published online Jan 15, 2014. doi: 10.4251/wjgo.v6.i1.22