Published online Sep 15, 2018. doi: 10.4251/wjgo.v10.i9.244
Peer-review started: April 16, 2018
First decision: April 27, 2018
Revised: June 5, 2018
Accepted: June 28, 2018
Article in press: June 28, 2018
Published online: September 15, 2018
Core tip: Colorectal carcinogenesis (CRC) imposes a major health burden. This review addresses the cell death mechanisms and major signal transduction pathways involved in CRC. Regulated cell death is important for maintaining normal homeostasis, and the dysregulation of cell death processes leads to a spectrum of diseases including cancer. It is interesting to note that cell death pathways collaborate with each other, so understanding the various cell death mechanisms are therefore essential. CRC is orchestrated by various signal transduction pathways, which are used as drug targets. This review highlights the key concepts concerning cell death mechanisms and signal transduction in CRC.