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Topic Highlight
Advanced gastric cancer: Current treatment landscape and future perspectives 
Antonia Digklia, Anna Dorothea Wagner 
World J Gastroenterol 22(8):2403-2414. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2403
Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer 
Masakazu Yashiro, Tasuku Matsuoka 
World J Gastroenterol 22(8):2415-2423. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2415
Current status in remnant gastric cancer after distal gastrectomy 
Masaichi Ohira, Takahiro Toyokawa, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Naoyoshi Onoda, Kosei Hirakawa 
World J Gastroenterol 22(8):2424-2433. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2424
Emerging molecular basis of hematogenous metastasis in gastric cancer 
Jing Zhong, Yan Chen, Liang-Jing Wang 
World J Gastroenterol 22(8):2434-2440. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2434
Review
Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer 
Simone Polvani, Mirko Tarocchi, Sara Tempesti, Lapo Bencini, Andrea Galli 
World J Gastroenterol 22(8):2441-2459. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2441
Molecular alterations in gastric cancer with special reference to the early-onset subtype 
Małgorzata Skierucha, Anya NA Milne, G Johan A Offerhaus, Wojciech P Polkowski, Ryszard Maciejewski, Robert Sitarz 
World J Gastroenterol 22(8):2460-2474. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2460
Estrogen receptors in gastric cancer: Advances and perspectives 
Muhammad Saif Ur Rahman, Jiang Cao 
World J Gastroenterol 22(8):2475-2482. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2475
Glycosyltransferases and non-alcoholic fatty liver disease 
Yu-Tao Zhan, Hai-Ying Su, Wei An 
World J Gastroenterol 22(8):2483-2493. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2483
Minireviews
Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state of play 
Bérénice Charrez, Liang Qiao, Lionel Hebbard 
World J Gastroenterol 22(8):2494-2502. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2494
Basic Study
Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer 
Dai Shida, Satoru Inoue, Yuki Yoshida, Atsushi Kodaka, Tsutomu Tsuji, Makoto Tsuiji 
World J Gastroenterol 22(8):2503-2511. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2503
Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice 
Takaya Yamamoto, Yukiomi Nakade, Taeko Yamauchi, Yuji Kobayashi, Norimitsu Ishii, Tomohiko Ohashi, Kiyoaki Ito, Ken Sato, Yoshitaka Fukuzawa, Masashi Yoneda 
World J Gastroenterol 22(8):2512-2523. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2512
Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer 
He-Jin Jia, Peng-Jun Zhang, Yu-Lan Liu, Chao-Guang Jiang, Xu Zhu, Ya-Ping Tian 
World J Gastroenterol 22(8):2524-2532. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2524
Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation 
Yong-Heng Sui, Wen-Jing Luo, Qin-Yu Xu, Jing Hua 
World J Gastroenterol 22(8):2533-2544. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2533
Role of CD56-expressing immature biliary epithelial cells in biliary atresia 
Rui-Zhong Zhang, Jia-Kang Yu, Jiao Peng, Feng-Hua Wang, Hai-Ying Liu, Vincent CH Lui, John M Nicholls, Paul KH Tam, Jonathan R Lamb, Yan Chen, Hui-Min Xia 
World J Gastroenterol 22(8):2545-2557. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2545
Improved prescription of taohechengqi-tang alleviates D-galactosamine acute liver failure in rats 
Yang Zhang, Jian-Xing Luo, Xiao-Yu Hu, Fang Yang, Sen Zhong, Wu Lin 
World J Gastroenterol 22(8):2558-2565. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2558
Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats 
Tie-Ming Ma, Na Xu, Xian-De Ma, Zeng-Hua Bai, Xing Tao, Hong-Chi Yan 
World J Gastroenterol 22(8):2566-2575. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2566
Case Control Study
Significance and prognostic value of increased serum direct bilirubin level for lymph node metastasis in Chinese rectal cancer patients 
Chun Gao, Long Fang, Jing-Tao Li, Hong-Chuan Zhao 
World J Gastroenterol 22(8):2576-2584. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2576
Retrospective Cohort Study
Risk factors for tuberculosis after gastrectomy in gastric cancer 
Won Jai Jung, Young Mok Park, Joo Han Song, Kyung Soo Chung, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Sung Hoon Noh, Ji Yeong An, Young Ae Kang 
World J Gastroenterol 22(8):2585-2591. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2585
Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease 
Myong Ki Baeg, Seung Kew Yoon, Sun-Hye Ko, Yong-Sun Noh, In-Seok Lee, Myung-Gyu Choi 
World J Gastroenterol 22(8):2592-2600. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2592
Prognostic factors and long-term outcomes of hilar cholangiocarcinoma: A single-institution experience in China 
Hai-Jie Hu, Hui Mao, Anuj Shrestha, Yong-Qiong Tan, Wen-Jie Ma, Qin Yang, Jun-Ke Wang, Nan-Sheng Cheng, Fu-Yu Li 
World J Gastroenterol 22(8):2601-2610. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2601
Retrospective Study
Outcomes and patients’ perspectives of transition from paediatric to adult care in inflammatory bowel disease 
Alice L Bennett, David Moore, Peter A Bampton, Robert V Bryant, Jane M Andrews 
World J Gastroenterol 22(8):2611-2620. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2611
Feasibility of full-spectrum endoscopy: Korea’s first full-spectrum endoscopy colonoscopic trial 
Jeong-Yeop Song, Youn Hee Cho, Mi A Kim, Jeong-Ae Kim, Chun Tek Lee, Moon Sung Lee 
World J Gastroenterol 22(8):2621-2629. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2621
Case Report
Ombitasvir, paritaprevir, ritonavir, dasabuvir and ribavirin in cirrhosis after complete destruction of hepatocellular carcinoma 
Zahariy Krastev, Deian Jelev, Krasimir Antonov, Tanya Petkova, Evelina Atanasova, Nadezhda Zheleva, Bojidar Tomov, Yana Boyanova, Lyudmila Mateva 
World J Gastroenterol 22(8):2630-2635. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2630
Condyloma acuminatum of the anal canal, treated with endoscopic submucosal dissection 
Akiko Sasaki, Takeshi Nakajima, Hideto Egashira, Kotaro Takeda, Shinnosuke Tokoro, Chikamasa Ichita, Sakue Masuda, Haruki Uojima, Kazuya Koizumi, Takeshi Kinbara, Taku Sakamoto, Yutaka Saito, Makoto Kako 
World J Gastroenterol 22(8):2636-2641. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2636
Terminal ileum gangrene secondary to a type IV paraesophageal hernia 
Ching Tsai Hsu, Po Jen Hsiao, Chih Chien Chiu, Jenq Shyong Chan, Yee Fung Lin, Yuan Hung Lo, Chia Jen Hsiao 
World J Gastroenterol 22(8):2642-2646. Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2642