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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2016; 22(8): 2475-2482
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2475
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2475
Estrogen receptors in gastric cancer: Advances and perspectives
Muhammad Saif Ur Rahman, Jiang Cao, Clinical Research Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Rahman MS and Cao J wrote the paper.
Supported by The National Natural Science Foundation of China, No. 30271450, No. 30471955, No. 30672365 and No. 81172516.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jiang Cao, PhD, Clinical Research Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. caoj@zju.edu.cn
Telephone: +86-571-87315202 Fax: +86-571-87315201
Received: September 30, 2015
Peer-review started: October 1, 2015
First decision: November 5, 2015
Revised: November 23, 2015
Accepted: December 12, 2015
Article in press: December 14, 2015
Published online: February 28, 2016
Peer-review started: October 1, 2015
First decision: November 5, 2015
Revised: November 23, 2015
Accepted: December 12, 2015
Article in press: December 14, 2015
Published online: February 28, 2016
Core Tip
Core tip: Gastric cancer is one of the common malignancies worldwide with high mortality. Estrogen receptors (ERs) are steroid hormone receptors that regulate cellular activities in many physiological and pathological processes of different tissues. Dysregulation of ERs is associated with many diseases, including gastric cancer. Studies have been conducted to investigate the roles that ERs play in gastric cancer and the clinical relevance of deregulated ERs in gastric cancer patients. This review focuses on the current understanding of ERs in gastric cancer and proposes directions for future investigations.