Estrogen receptors in gastric cancer: Advances and perspectives

Table 1 Summary of the association between estrogen receptor isoforms and gastric cancer

Estrogen receptors	Isoform	Association with gastric cancer
ERα	ERα66	No significant correlation between ERα66 and gastric cancer is found[27]
		No positive significant difference in both male and female[27,28]
		Incidence higher in poorly differentiated adenocarcinoma[28]
		Association with diffused type gastric cancer is found[31]
		Associated with poor overall survival[31]
	ERα46	No reported result has been up to date
	ERα36	Expressed highly in gastric cancer[34]
		Expression correlated with lymph node metastasis[34]
		Expressed in plasma membrane and cytoplasm of gastric cancer[34]
ERβ	ERβ1	Associated with low tumor grades[32]
	ERβ2	Presence could have protective effect against invasion[32]
	ERβ3	Absence of ERβ a significant independent prognostic factor for poor OS[15]
	ERβ4	ERβ5 is associated with PTNM stage[39]
	ERβ5

ER: Estrogen receptor; OS: Overall survival.