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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2016; 22(2): 649-658
Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.649
Helicobacter pylori and colorectal neoplasia: Is there a causal link?
Vasilios Papastergiou, Stylianos Karatapanis, Sotirios D Georgopoulos
Vasilios Papastergiou, Stylianos Karatapanis, Department of Internal Medicine, General Hospital of Rhodes, 85100 Rhodes, Greece
Sotirios D Georgopoulos, Department of Gastroenterology, Athens Medical, Paleo Faliron General Hospital, 17562 Athens, Greece
Author contributions: Papastergiou V contributed to conception and design, drafting the article; Georgopoulos SD contributed to drafting the article, revising the article critically for important intellectual content; Karatapanis S contributed to final approval of the version to be published.
Conflict-of-interest statement: The authors have nothing to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Sotirios D Georgopoulos, MD, FEBGH, AGAF, Director, Division of Internal Medicine, Department of Gastroenterology, Athens Medical, Paleo Faliron General Hospital, Areos 36, Paleo Faliron, 17562 Athens, Greece.
Telephone: +30-210-9892100
Received: April 10, 2015
Peer-review started: April 11, 2015
First decision: May 18, 2015
Revised: July 1, 2015
Accepted: September 30, 2015
Article in press: September 30, 2015
Published online: January 14, 2016
Core Tip

Core tip:Helicobacter pylori (H. pylori) is a well-recognized gastric carcinogen; however, a causal relationship with colorectal neoplasia remains uncertain. Data from case-control and cross-sectional studies, as well as several meta-analyses, have indicated a significant, although modest, statistical association between infection with H. pylori/H. pylori-related gastritis and the development of colorectal adenomas or cancer. Potential tumorigenic actions of H. pylori to colorectal mucosa include induction of inflammatory responses, alteration of gut microflora and release of toxins and/or hormonal mediators.