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Open-Access Journal
Editorial
Crohn's disease presenting as acute gastrointestinal hemorrhage 
Amareshwar Podugu, Kanwarpreet Tandon, Fernando J Castro 
World J Gastroenterol 22(16):4073-4078. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4073
Topic Highlight
Nonalcoholic fatty liver disease as a multi-systemic disease 
Hakan Fotbolcu, Elçin Zorlu 
World J Gastroenterol 22(16):4079-4090. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4079
Basic Study
Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease 
Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, Gyongyi Szabo 
World J Gastroenterol 22(16):4091-4108. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4091
Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines 
Gursimran Chandhok, Judit Horvath, Annu Aggarwal, Mohit Bhatt, Andree Zibert, Hartmut HJ Schmidt 
World J Gastroenterol 22(16):4109-4119. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4109
Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy 
Jian-Feng Sang, Xiao-Lei Shi, Bing Han, Xu Huang, Tao Huang, Hao-Zhen Ren, Yi-Tao Ding 
World J Gastroenterol 22(16):4120-4135. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4120
Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats 
Dan-Dan Gao, Jia Fu, Bo Qin, Wen-Xiang Huang, Chun Yang, Bei Jia 
World J Gastroenterol 22(16):4136-4148. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4136
Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro 
Wen-Qian Zhu, Jun Wang, Xu-Feng Guo, Zhou Liu, Wei-Guo Dong 
World J Gastroenterol 22(16):4149-4159. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4149
Case Control Study
Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis 
Mohamad Mokadem, Lama Noureddine, Thomas Howard, Lee McHenry, Stuart Sherman, Evan L Fogel, James L Watkins, Glen A Lehman 
World J Gastroenterol 22(16):4160-4167. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4160
Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model 
Abdel-Rahman Nabawy Zekri, Amira Salah El-Din Youssef, Yasser Mabrouk Bakr, Reham Mohamed Gabr, Ola Sayed Ahmed, Mostafa Hamed Elberry, Ahmed Mahmoud Mayla, Mohamed Abouelhoda, Abeer A Bahnassy 
World J Gastroenterol 22(16):4168-4182. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4168
Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort 
Jun-Hu Chen, Yan-Yan Wang, Wei-Biao Lv, Yu Gan, Wei Chang, Na-Na Tian, Xiao-Hui Huang, Li Liu, Xin-Fa Yu, Si-Dong Chen 
World J Gastroenterol 22(16):4183-4190. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4183
Retrospective Study
Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study 
I Jane Cox, Abil E Aliev, Mary ME Crossey, Mahvish Dawood, Mamun Al-Mahtab, Sheikh M Akbar, Salimur Rahman, Antonio Riva, Roger Williams, Simon D Taylor-Robinson 
World J Gastroenterol 22(16):4191-4200. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4191
Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor 
Mireen Friedrich-Rust, Beate Wanger, Florian Heupel, Natalie Filmann, Reinhard Brodt, Volkhard AJ Kempf, Johanna Kessel, Thomas A Wichelhaus, Eva Herrmann, Stefan Zeuzem, Joerg Bojunga 
World J Gastroenterol 22(16):4201-4210. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4201
Lymphocyte-to-monocyte ratio predicts survival after radiofrequency ablation for colorectal liver metastases 
Antonio Facciorusso, Valentina Del Prete, Nicola Crucinio, Gaetano Serviddio, Gianluigi Vendemiale, Nicola Muscatiello 
World J Gastroenterol 22(16):4211-4218. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4211
Predictors of poor outcome in gastrointestinal bleeding in emergency department 
Ender Kaya, Mehmet Ali Karaca, Deniz Aldemir, M Mahir Ozmen 
World J Gastroenterol 22(16):4219-4225. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4219
Eukaryotic elongation factor-1α 2 knockdown inhibits hepatocarcinogenesis by suppressing PI3K/Akt/NF-κB signaling 
Fu-Nan Qiu, Yi Huang, Dun-Yan Chen, Feng Li, Yan-An Wu, Wen-Bing Wu, Xiao-Li Huang 
World J Gastroenterol 22(16):4226-4237. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4226
Observational Study
Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter? 
Behairy El-Sayed Behairy, Mostafa Mohamed Sira, Khaled Refat Zalata, El-Sayed Ebrahem Salama, Mohamed Ahmed Abd-Allah 
World J Gastroenterol 22(16):4238-4249. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4238
Prospective Study
Predictive effects of bilirubin on response of colorectal cancer to irinotecan-based chemotherapy 
Qian-Qian Yu, Hong Qiu, Ming-Sheng Zhang, Guang-Yuan Hu, Bo Liu, Liu Huang, Xin Liao, Qian-Xia Li, Zhi-Huan Li, Xiang-Lin Yuan 
World J Gastroenterol 22(16):4250-4258. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4250
Case Report
Pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion from an aortic intramural hematoma 
Akihiko Sakatani, Yoshinori Doi, Toshiaki Kitayama, Takaaki Matsuda, Yasutaka Sasai, Naohiro Nishida, Megumi Sakamoto, Naoto Uenoyama, Kazuo Kinoshita 
World J Gastroenterol 22(16):4259-4263. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4259
Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis 
Kosuke Minaga, Masayuki Kitano, Hajime Imai, Kentaro Yamao, Ken Kamata, Takeshi Miyata, Shunsuke Omoto, Kumpei Kadosaka, Tomoe Yoshikawa, Masatoshi Kudo 
World J Gastroenterol 22(16):4264-4269. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4264
Occult gastric cancer with distant metastasis proven by random gastric biopsy 
Sang Hyuk Lee, Kyu-Hyoung Lim, Seo-Young Song, Hui-Young Lee, Sung Chul Park, Chang Don Kang, Sung Joon Lee, Dong Wook Choi, Sung Bae Park, Young-Joon Ryu 
World J Gastroenterol 22(16):4270-4274. Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4270