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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2016; 22(16): 4201-4210
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4201
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4201
Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor
Mireen Friedrich-Rust, Beate Wanger, Florian Heupel, Stefan Zeuzem, Joerg Bojunga, Department of Internal Medicine I (Gastroenterology, Pulmonology, Endocrinology), J.W. Goethe-University Hospital, 60590 Frankfurt, Germany
Natalie Filmann, Eva Herrmann, Institute of Biostatistics and Mathematical Modeling, Faculty of Medicine, J.W. Goethe-University, 60590 Frankfurt, Germany
Reinhard Brodt, Johanna Kessel, Department of Internal Medicine II (Infectious Disease, Oncology, Hematology), J.W. Goethe-University Hospital, 60590 Frankfurt, Germany
Volkhard AJ Kempf, Thomas A Wichelhaus, Institute of Medical Microbiology and Infection Control, J.W. Goethe-University Hospital, 60590 Frankfurt, Germany
Author contributions: Friedrich-Rust M, Herrmann E, Bojunga J participated in the design of the study; all authors participated in the clinical study, data acquisition and extraction; Friedrich-Rust M, Wanger B, Heupel F, Filmann N and Herrmann E performed the statistical analysis; Friedrich-Rust M, Wanger B, Heupel F, Filmann N, Bojunga J participated in the drafting of the manuscript; all authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the University Clinic Frankfurt.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained retrospectively.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Mireen Friedrich-Rust, Professor, Department of Internal Medicine I (Gastroenterology, Pulmonology, Endocrinology), J.W. Goethe-University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. mireen.friedrich-rust@kgu.de
Telephone: +49-69-63015297 Fax: +49-69-63016247
Received: January 13, 2016
Peer-review started: January 16, 2016
First decision: January 28, 2016
Revised: February 9, 2016
Accepted: March 13, 2016
Article in press: March 14, 2016
Published online: April 28, 2016
Peer-review started: January 16, 2016
First decision: January 28, 2016
Revised: February 9, 2016
Accepted: March 13, 2016
Article in press: March 14, 2016
Published online: April 28, 2016
Core Tip
Core tip: This is a retrospective study evaluating the association of appropriate and inappropriate antimicrobial therapy on intensive care unit-mortality with special focus on patients with liver cirrhosis. Charts of 1979 patients were available for analysis. Patients with infection had significantly increased in-hospital mortality. Only 9% of patients with infection received inappropriate initial antimicrobial therapy. Multiresistant bacteria were detected in 23% of patients with infection and were associated with increased mortality. Infection increased mortality 2.24-fold in patients with cirrhosis. Patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.