Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model
Abdel-Rahman Nabawy Zekri, Amira Salah El-Din Youssef, Yasser Mabrouk Bakr, Reham Mohamed Gabr, Ola Sayed Ahmed, Mostafa Hamed Elberry, Ahmed Mahmoud Mayla, Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11976, Egypt
Mohamed Abouelhoda, Systems and Biomedical Engineering Department, Faculty of Engineering, Cairo University, Giza 16453, Egypt
Mohamed Abouelhoda, Center for Informatics Sciences, Nile University, Sheikh Zayed City, Giza 16453, Egypt
Abeer A Bahnassy, Pathology Department, National Cancer Institute, Cairo University, Cairo 11976, Egypt
Author contributions: Zekri AR designed the study, edited the manuscript and helped in creating the model; Youssef AS participated in sample collection and manuscript writing and editing; Bakr YM assisted with the practical work and statistical analysis; Gabr RM and Ahmed OS assisted with the practical work; Elberry MH, Mayla AM and Bahnassy AA assisted with editing the manuscript; Abouelhoda M assited with creating the model.
Supported by National Cancer Institute, Cairo University, Cairo, Egypt.
Institutional review board statement: The study was approved by the Ethics Committee of National Cancer Institute, Cairo University, Cairo, Egypt (IRB No. 00004025, IORG. 0003381).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Data sharing statement: The technical appendix, statistical code, and dataset are available from the corresponding author at email@example.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Abdel-Rahman Nabawy Zekri, PhD, Head, Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Kasr Al-Aini street, Fom El-Khaleeg, Cairo 11976, Egypt. firstname.lastname@example.org
Telephone: +20-2-22742607 Fax: +20-2-23644720
Received: November 30, 2015
Peer-review started: December 2, 2015
First decision: January 13, 2016
Revised: February 16, 2016
Accepted: March 1, 2016
Article in press: March 2, 2016
Published online: April 28, 2016