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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
Focal liver lesions: Practical magnetic resonance imaging approach  
António P Matos, Fernanda Velloni, Miguel Ramalho, Mamdoh AlObaidy, Aruna Rajapaksha, Richard C Semelka 
World J Hepatol 7(16):1987-2008. Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.1987
Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests  
Rolf Teschke, Christian Frenzel, Johannes Schulze, Alexander Schwarzenboeck, Axel Eickhoff 
World J Hepatol 5(7):353-363. Published online Jul 27, 2013. doi: 10.4254/wjh.v5.i7.353
Current status of imaging in nonalcoholic fatty liver disease  
Qian Li, Manish Dhyani, Joseph R Grajo, Claude Sirlin, Anthony E Samir 
World J Hepatol 10(8):530-542. Published online Aug 27, 2018. doi: 10.4254/wjh.v10.i8.530
Acute liver injury induced by weight-loss herbal supplements  
Gary C Chen, Vivek S Ramanathan, David Law, Pauline Funchain, George C Chen, Samuel French, Boris Shlopov, Viktor Eysselein, David Chung, Sonya Reicher, Binh V Pham 
World J Hepatol 2(11):410-415. Published online Nov 27, 2010. doi: 10.4254/wjh.v2.i11.410
Hepatitis C virus: Morphogenesis, infection and therapy  
Vladimir Alexei Morozov, Sylvie Lagaye 
World J Hepatol 10(2):186-212. Published online Feb 27, 2018. doi: 10.4254/wjh.v10.i2.186
Non-alcoholic fatty liver disease: The diagnosis and management  
Shehab M Abd El-Kader, Eman M Salah El-Den Ashmawy 
World J Hepatol 7(6):846-858. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.846
Vitamin D deficiency in chronic liver disease  
Paula Iruzubieta, Álvaro Terán, Javier Crespo, Emilio Fábrega 
World J Hepatol 6(12):901-915. Published online Dec 27, 2014. doi: 10.4254/wjh.v6.i12.901
Portal hypertensive gastropathy: A systematic review of the pathophysiology, clinical presentation, natural history and therapy  
Mihajlo Gjeorgjievski, Mitchell S Cappell 
World J Hepatol 8(4):231-262. Published online Feb 8, 2016. doi: 10.4254/wjh.v8.i4.231
Abnormal liver enzymes: A review for clinicians  
M Ammar Kalas, Luis Chavez, Monica Leon, Pahnwat Tonya Taweesedt, Salim Surani 
World J Hepatol 13(11):1688-1698. Published online Nov 27, 2021. doi: 10.4254/wjh.v13.i11.1688
Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs  
Cyriac Abby Philips, Rizwan Ahamed, Sasidharan Rajesh, Tom George, Meera Mohanan, Philip Augustine 
World J Hepatol 12(9):574-595. Published online Sep 27, 2020. doi: 10.4254/wjh.v12.i9.574
Liver failure caused by prolonged state of malnutrition following bariatric surgery  
Willem J Lammers, Antonie JP van Tilburg, Jan A Apers, Janneke Wiebolt 
World J Hepatol 10(3):396-399. Published online Mar 27, 2018. doi: 10.4254/wjh.v10.i3.396
Staging of liver fibrosis or cirrhosis: The role of hepatic venous pressure gradient measurement  
Ki Tae Suk, Dong Joon Kim 
World J Hepatol 7(3):607-615. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.607
MR with Gd-EOB-DTPA in assessment of liver nodules in cirrhotic patients  
Riccardo Inchingolo, Riccardo Faletti, Luigi Grazioli, Eleonora Tricarico, Marco Gatti, Anna Pecorelli, Davide Ippolito 
World J Hepatol 10(7):462-473. Published online Jul 27, 2018. doi: 10.4254/wjh.v10.i7.462
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis  
Linda Pasta, Francesca Pasta 
World J Hepatol 7(29):2920-2926. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2920
Bacterial infections in cirrhosis: A critical review and practical guidance  
Chalermrat Bunchorntavakul, Naichaya Chamroonkul, Disaya Chavalitdhamrong 
World J Hepatol 8(6):307-321. Published online Feb 28, 2016. doi: 10.4254/wjh.v8.i6.307
Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases  
Waihong Chung, Kittichai Promrat, Jack Wands 
World J Hepatol 12(9):533-557. Published online Sep 27, 2020. doi: 10.4254/wjh.v12.i9.533
Current status of diagnosis and treatment of hepatic echinococcosis  
Memmet Mihmanli, Ufuk Oguz Idiz, Cemal Kaya, Uygar Demir, Ozgur Bostanci, Sinan Omeroglu, Emre Bozkurt 
World J Hepatol 8(28):1169-1181. Published online Oct 8, 2016. doi: 10.4254/wjh.v8.i28.1169
Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy  
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jonathan David Roth, Jacob Jelsing, Niels Vrang, Michael Feigh 
World J Hepatol 8(16):673-684. Published online Jun 8, 2016. doi: 10.4254/wjh.v8.i16.673
Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease  
Mustafa Koplay, Mesut Sivri, Hasan Erdogan, Alaaddin Nayman 
World J Hepatol 7(5):769-776. Published online Apr 18, 2015. doi: 10.4254/wjh.v7.i5.769
Wilson’s disease: A review of what we have learned  
Kryssia Isabel Rodriguez-Castro, Francisco Javier Hevia-Urrutia, Giacomo Carlo Sturniolo 
World J Hepatol 7(29):2859-2870. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2859
Cystic echinococcosis of the liver: A primer for hepatologists  
Francesca Rinaldi, Enrico Brunetti, Andreas Neumayr, Marcello Maestri, Samuel Goblirsch, Francesca Tamarozzi 
World J Hepatol 6(5):293-305. Published online May 27, 2014. doi: 10.4254/wjh.v6.i5.293
Hepatocellular carcinoma in non-cirrhotic liver: A comprehensive review  
Aakash Desai, Sonia Sandhu, Jin-Ping Lai, Dalbir Singh Sandhu 
World J Hepatol 11(1):1-18. Published online Jan 27, 2019. doi: 10.4254/wjh.v11.i1.1
Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease  
Hye-jin Yoon, Bong Soo Cha 
World J Hepatol 6(11):800-811. Published online Nov 27, 2014. doi: 10.4254/wjh.v6.i11.800
Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside  
Bing Hu, Shuang-Shuang Wang, Qin Du 
World J Hepatol 7(9):1209-1232. Published online May 28, 2015. doi: 10.4254/wjh.v7.i9.1209
Concept of the pathogenesis and treatment of cholelithiasis  
Vasiliy Ivanovich Reshetnyak 
World J Hepatol 4(2):18-34. Published online Feb 27, 2012. doi: 10.4254/wjh.v4.i2.18
Prediction of liver cirrhosis, using diagnostic imaging tools  
Suk Keu Yeom, Chang Hee Lee, Sang Hoon Cha, Cheol Min Park 
World J Hepatol 7(17):2069-2079. Published online Aug 18, 2015. doi: 10.4254/wjh.v7.i17.2069
Alcoholic liver disease  
Radan Bruha, Karel Dvorak, Jaromir Petrtyl 
World J Hepatol 4(3):81-90. Published online Mar 27, 2012. doi: 10.4254/wjh.v4.i3.81
Cirrhotic ascites review: Pathophysiology, diagnosis and management  
Christopher M Moore, David H Van Thiel 
World J Hepatol 5(5):251-263. Published online May 27, 2013. doi: 10.4254/wjh.v5.i5.251
Hepatitis C virus syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin’s lymphoma, and cancer  
Clodoveo Ferri, Marco Sebastiani, Dilia Giuggioli, Michele Colaci, Poupak Fallahi, Alessia Piluso, Alessandro Antonelli, Anna Linda Zignego 
World J Hepatol 7(3):327-343. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.327
Vascular complications following liver transplantation: A literature review of advances in 2015  
Tullio Piardi, Martin Lhuaire, Onorina Bruno, Riccardo Memeo, Patrick Pessaux, Reza Kianmanesh, Daniele Sommacale 
World J Hepatol 8(1):36-57. Published online Jan 8, 2016. doi: 10.4254/wjh.v8.i1.36
Liver injury induced by paracetamol and challenges associated with intentional and unintentional use  
Laura Rotundo, Nikolaos Pyrsopoulos 
World J Hepatol 12(4):125-136. Published online Apr 27, 2020. doi: 10.4254/wjh.v12.i4.125
Hepatitis C virus genetic variability and evolution  
Natalia Echeverría, Gonzalo Moratorio, Juan Cristina, Pilar Moreno 
World J Hepatol 7(6):831-845. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.831
Guide for diagnosis and treatment of hepatocellular carcinoma  
Magdy Hamed Attwa, Shahira Aly El-Etreby 
World J Hepatol 7(12):1632-1651. Published online Jun 28, 2015. doi: 10.4254/wjh.v7.i12.1632
Cholesterol metabolism in cholestatic liver disease and liver transplantation: From molecular mechanisms to clinical implications  
Katriina Nemes, Fredrik Åberg, Helena Gylling, Helena Isoniemi 
World J Hepatol 8(22):924-932. Published online Aug 8, 2016. doi: 10.4254/wjh.v8.i22.924
Hepatocellular carcinoma: Review of disease and tumor biomarkers  
Jin Un Kim, Mohamed I F Shariff, Mary M E Crossey, Maria Gomez-Romero, Elaine Holmes, I Jane Cox, Haddy K S Fye, Ramou Njie, Simon D Taylor-Robinson 
World J Hepatol 8(10):471-484. Published online Apr 8, 2016. doi: 10.4254/wjh.v8.i10.471
Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience  
Matthew M Yeh, Raymond S Yeung, Smith Apisarnthanarax, Renuka Bhattacharya, Carlos Cuevas, William P Harris, Tony Lim Kiat Hon, Siddharth A Padia, James O Park, Kevin M Riggle, Sayed S Daoud 
World J Hepatol 7(11):1460-1483. Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1460
Review on immunosuppression in liver transplantation  
Maryam Moini, Michael L Schilsky, Eric M Tichy 
World J Hepatol 7(10):1355-1368. Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1355
Physiopathology of splanchnic vasodilation in portal hypertension  
María Martell, Mar Coll, Nahia Ezkurdia, Imma Raurell, Joan Genescà 
World J Hepatol 2(6):208-220. Published online Jun 27, 2010. doi: 10.4254/wjh.v2.i6.208
Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion  
Christopher Valerio, Eleni Theocharidou, Andrew Davenport, Banwari Agarwal 
World J Hepatol 8(7):345-354. Published online Mar 8, 2016. doi: 10.4254/wjh.v8.i7.345
Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy  
Treta Purohit, Mitchell S Cappell 
World J Hepatol 7(7):926-941. Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.926
Hepatitis B virus and hepatitis C virus infection in healthcare workers  
Nicola Coppola, Stefania De Pascalis, Lorenzo Onorato, Federica Calò, Caterina Sagnelli, Evangelista Sagnelli 
World J Hepatol 8(5):273-281. Published online Feb 18, 2016. doi: 10.4254/wjh.v8.i5.273
Management of hepatitis B reactivation in immunosuppressed patients: An update on current recommendations  
Fernando Bessone, Melisa Dirchwolf 
World J Hepatol 8(8):385-394. Published online Mar 18, 2016. doi: 10.4254/wjh.v8.i8.385
Hepatocellular carcinoma in non-alcoholic steatohepatitis: Current knowledge and implications for management  
George Cholankeril, Ronak Patel, Sandeep Khurana, Sanjaya K Satapathy 
World J Hepatol 9(11):533-543. Published online Apr 18, 2017. doi: 10.4254/wjh.v9.i11.533
Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study  
Dieter Melchart, Stefan Hager, Sabine Albrecht, Jingzhang Dai, Wolfgang Weidenhammer, Rolf Teschke 
World J Hepatol 9(29):1141-1157. Published online Oct 18, 2017. doi: 10.4254/wjh.v9.i29.1141
Chronic hepatitis C: This and the new era of treatment  
Gaetano Bertino, Annalisa Ardiri, Maria Proiti, Giuseppe Rigano, Evelise Frazzetto, Shirin Demma, Maria Irene Ruggeri, Laura Scuderi, Giulia Malaguarnera, Nicoletta Bertino, Venerando Rapisarda, Isidoro Di Carlo, Adriana Toro, Federico Salomone, Mariano Malaguarnera, Emanuele Bertino, Michele Malaguarnera 
World J Hepatol 8(2):92-106. Published online Jan 18, 2016. doi: 10.4254/wjh.v8.i2.92
Immunotherapy for hepatocellular carcinoma: From basic research to clinical use  
Yu-Peng Hong, Zi-Duo Li, Pankaj Prasoon, Qi Zhang 
World J Hepatol 7(7):980-992. Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.980