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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Focal liver lesions: Practical magnetic resonance imaging approach  
António P Matos, Fernanda Velloni, Miguel Ramalho, Mamdoh AlObaidy, Aruna Rajapaksha, Richard C Semelka 
World J Hepatol 7(16):1987-2008. Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.1987
2
Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests  
Rolf Teschke, Christian Frenzel, Johannes Schulze, Alexander Schwarzenboeck, Axel Eickhoff 
World J Hepatol 5(7):353-363. Published online Jul 27, 2013. doi: 10.4254/wjh.v5.i7.353
3
Current status of imaging in nonalcoholic fatty liver disease  
Qian Li, Manish Dhyani, Joseph R Grajo, Claude Sirlin, Anthony E Samir 
World J Hepatol 10(8):530-542. Published online Aug 27, 2018. doi: 10.4254/wjh.v10.i8.530
4
Acute liver injury induced by weight-loss herbal supplements  
Gary C Chen, Vivek S Ramanathan, David Law, Pauline Funchain, George C Chen, Samuel French, Boris Shlopov, Viktor Eysselein, David Chung, Sonya Reicher, Binh V Pham 
World J Hepatol 2(11):410-415. Published online Nov 27, 2010. doi: 10.4254/wjh.v2.i11.410
5
Hepatitis C virus: Morphogenesis, infection and therapy  
Vladimir Alexei Morozov, Sylvie Lagaye 
World J Hepatol 10(2):186-212. Published online Feb 27, 2018. doi: 10.4254/wjh.v10.i2.186
6
Vitamin D deficiency in chronic liver disease  
Paula Iruzubieta, Álvaro Terán, Javier Crespo, Emilio Fábrega 
World J Hepatol 6(12):901-915. Published online Dec 27, 2014. doi: 10.4254/wjh.v6.i12.901
7
Non-alcoholic fatty liver disease: The diagnosis and management  
Shehab M Abd El-Kader, Eman M Salah El-Den Ashmawy 
World J Hepatol 7(6):846-858. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.846
8
9
Abnormal liver enzymes: A review for clinicians  
M Ammar Kalas, Luis Chavez, Monica Leon, Pahnwat Tonya Taweesedt, Salim Surani 
World J Hepatol 13(11):1688-1698. Published online Nov 27, 2021. doi: 10.4254/wjh.v13.i11.1688
10
11
Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs  
Cyriac Abby Philips, Rizwan Ahamed, Sasidharan Rajesh, Tom George, Meera Mohanan, Philip Augustine 
World J Hepatol 12(9):574-595. Published online Sep 27, 2020. doi: 10.4254/wjh.v12.i9.574
12
Portal hypertensive gastropathy: A systematic review of the pathophysiology, clinical presentation, natural history and therapy  
Mihajlo Gjeorgjievski, Mitchell S Cappell 
World J Hepatol 8(4):231-262. Published online Feb 8, 2016. doi: 10.4254/wjh.v8.i4.231
13
14
Staging of liver fibrosis or cirrhosis: The role of hepatic venous pressure gradient measurement  
Ki Tae Suk, Dong Joon Kim 
World J Hepatol 7(3):607-615. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.607
15
Liver failure caused by prolonged state of malnutrition following bariatric surgery  
Willem J Lammers, Antonie JP van Tilburg, Jan A Apers, Janneke Wiebolt 
World J Hepatol 10(3):396-399. Published online Mar 27, 2018. doi: 10.4254/wjh.v10.i3.396
16
MR with Gd-EOB-DTPA in assessment of liver nodules in cirrhotic patients  
Riccardo Inchingolo, Riccardo Faletti, Luigi Grazioli, Eleonora Tricarico, Marco Gatti, Anna Pecorelli, Davide Ippolito 
World J Hepatol 10(7):462-473. Published online Jul 27, 2018. doi: 10.4254/wjh.v10.i7.462
17
Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases  
Waihong Chung, Kittichai Promrat, Jack Wands 
World J Hepatol 12(9):533-557. Published online Sep 27, 2020. doi: 10.4254/wjh.v12.i9.533
18
Current status of diagnosis and treatment of hepatic echinococcosis  
Memmet Mihmanli, Ufuk Oguz Idiz, Cemal Kaya, Uygar Demir, Ozgur Bostanci, Sinan Omeroglu, Emre Bozkurt 
World J Hepatol 8(28):1169-1181. Published online Oct 8, 2016. doi: 10.4254/wjh.v8.i28.1169
19
Bacterial infections in cirrhosis: A critical review and practical guidance  
Chalermrat Bunchorntavakul, Naichaya Chamroonkul, Disaya Chavalitdhamrong 
World J Hepatol 8(6):307-321. Published online Feb 28, 2016. doi: 10.4254/wjh.v8.i6.307
20
Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease  
Mustafa Koplay, Mesut Sivri, Hasan Erdogan, Alaaddin Nayman 
World J Hepatol 7(5):769-776. Published online Apr 18, 2015. doi: 10.4254/wjh.v7.i5.769
21
Hepatocellular carcinoma in non-cirrhotic liver: A comprehensive review  
Aakash Desai, Sonia Sandhu, Jin-Ping Lai, Dalbir Singh Sandhu 
World J Hepatol 11(1):1-18. Published online Jan 27, 2019. doi: 10.4254/wjh.v11.i1.1
22
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis  
Linda Pasta, Francesca Pasta 
World J Hepatol 7(29):2920-2926. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2920
23
Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy  
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jonathan David Roth, Jacob Jelsing, Niels Vrang, Michael Feigh 
World J Hepatol 8(16):673-684. Published online Jun 8, 2016. doi: 10.4254/wjh.v8.i16.673
24
Wilson’s disease: A review of what we have learned  
Kryssia Isabel Rodriguez-Castro, Francisco Javier Hevia-Urrutia, Giacomo Carlo Sturniolo 
World J Hepatol 7(29):2859-2870. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2859
25
Prediction of liver cirrhosis, using diagnostic imaging tools  
Suk Keu Yeom, Chang Hee Lee, Sang Hoon Cha, Cheol Min Park 
World J Hepatol 7(17):2069-2079. Published online Aug 18, 2015. doi: 10.4254/wjh.v7.i17.2069
26
Cystic echinococcosis of the liver: A primer for hepatologists  
Francesca Rinaldi, Enrico Brunetti, Andreas Neumayr, Marcello Maestri, Samuel Goblirsch, Francesca Tamarozzi 
World J Hepatol 6(5):293-305. Published online May 27, 2014. doi: 10.4254/wjh.v6.i5.293
27
Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside  
Bing Hu, Shuang-Shuang Wang, Qin Du 
World J Hepatol 7(9):1209-1232. Published online May 28, 2015. doi: 10.4254/wjh.v7.i9.1209
28
Concept of the pathogenesis and treatment of cholelithiasis  
Vasiliy Ivanovich Reshetnyak 
World J Hepatol 4(2):18-34. Published online Feb 27, 2012. doi: 10.4254/wjh.v4.i2.18
29
Liver injury induced by paracetamol and challenges associated with intentional and unintentional use  
Laura Rotundo, Nikolaos Pyrsopoulos 
World J Hepatol 12(4):125-136. Published online Apr 27, 2020. doi: 10.4254/wjh.v12.i4.125
30
Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease  
Hye-jin Yoon, Bong Soo Cha 
World J Hepatol 6(11):800-811. Published online Nov 27, 2014. doi: 10.4254/wjh.v6.i11.800
31
Vascular complications following liver transplantation: A literature review of advances in 2015  
Tullio Piardi, Martin Lhuaire, Onorina Bruno, Riccardo Memeo, Patrick Pessaux, Reza Kianmanesh, Daniele Sommacale 
World J Hepatol 8(1):36-57. Published online Jan 8, 2016. doi: 10.4254/wjh.v8.i1.36
32
Cirrhotic ascites review: Pathophysiology, diagnosis and management  
Christopher M Moore, David H Van Thiel 
World J Hepatol 5(5):251-263. Published online May 27, 2013. doi: 10.4254/wjh.v5.i5.251
33
Alcoholic liver disease  
Radan Bruha, Karel Dvorak, Jaromir Petrtyl 
World J Hepatol 4(3):81-90. Published online Mar 27, 2012. doi: 10.4254/wjh.v4.i3.81
34
Hepatitis C virus syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin’s lymphoma, and cancer  
Clodoveo Ferri, Marco Sebastiani, Dilia Giuggioli, Michele Colaci, Poupak Fallahi, Alessia Piluso, Alessandro Antonelli, Anna Linda Zignego 
World J Hepatol 7(3):327-343. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.327
35
Hepatitis C virus genetic variability and evolution  
Natalia Echeverría, Gonzalo Moratorio, Juan Cristina, Pilar Moreno 
World J Hepatol 7(6):831-845. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.831
36
Guide for diagnosis and treatment of hepatocellular carcinoma  
Magdy Hamed Attwa, Shahira Aly El-Etreby 
World J Hepatol 7(12):1632-1651. Published online Jun 28, 2015. doi: 10.4254/wjh.v7.i12.1632
37
Cholesterol metabolism in cholestatic liver disease and liver transplantation: From molecular mechanisms to clinical implications  
Katriina Nemes, Fredrik Åberg, Helena Gylling, Helena Isoniemi 
World J Hepatol 8(22):924-932. Published online Aug 8, 2016. doi: 10.4254/wjh.v8.i22.924
38
Review on immunosuppression in liver transplantation  
Maryam Moini, Michael L Schilsky, Eric M Tichy 
World J Hepatol 7(10):1355-1368. Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1355
39
40
Hepatoprotective effect of silymarin  
Nancy Vargas-Mendoza, Eduardo Madrigal-Santillán, Ángel Morales-González, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Manuel García-Luna y González-Rubio, Juan A Gayosso-de-Lucio, José A Morales-González 
World J Hepatol 6(3):144-149. Published online Mar 27, 2014. doi: 10.4254/wjh.v6.i3.144
41
Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy  
Treta Purohit, Mitchell S Cappell 
World J Hepatol 7(7):926-941. Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.926
42
Hepatocellular carcinoma: Review of disease and tumor biomarkers  
Jin Un Kim, Mohamed I F Shariff, Mary M E Crossey, Maria Gomez-Romero, Elaine Holmes, I Jane Cox, Haddy K S Fye, Ramou Njie, Simon D Taylor-Robinson 
World J Hepatol 8(10):471-484. Published online Apr 8, 2016. doi: 10.4254/wjh.v8.i10.471
43
Hepatitis B virus and hepatitis C virus infection in healthcare workers  
Nicola Coppola, Stefania De Pascalis, Lorenzo Onorato, Federica Calò, Caterina Sagnelli, Evangelista Sagnelli 
World J Hepatol 8(5):273-281. Published online Feb 18, 2016. doi: 10.4254/wjh.v8.i5.273
44
Physiopathology of splanchnic vasodilation in portal hypertension  
María Martell, Mar Coll, Nahia Ezkurdia, Imma Raurell, Joan Genescà 
World J Hepatol 2(6):208-220. Published online Jun 27, 2010. doi: 10.4254/wjh.v2.i6.208
45
Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion  
Christopher Valerio, Eleni Theocharidou, Andrew Davenport, Banwari Agarwal 
World J Hepatol 8(7):345-354. Published online Mar 8, 2016. doi: 10.4254/wjh.v8.i7.345
46
Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience  
Matthew M Yeh, Raymond S Yeung, Smith Apisarnthanarax, Renuka Bhattacharya, Carlos Cuevas, William P Harris, Tony Lim Kiat Hon, Siddharth A Padia, James O Park, Kevin M Riggle, Sayed S Daoud 
World J Hepatol 7(11):1460-1483. Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1460
47
Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice  
Kandy T Velázquez, Reilly T Enos, Jackie E Bader, Alexander T Sougiannis, Meredith S Carson, Ioulia Chatzistamou, James A Carson, Prakash S Nagarkatti, Mitzi Nagarkatti, E Angela Murphy 
World J Hepatol 11(8):619-637. Published online Aug 27, 2019. doi: 10.4254/wjh.v11.i8.619
48
Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study  
Dieter Melchart, Stefan Hager, Sabine Albrecht, Jingzhang Dai, Wolfgang Weidenhammer, Rolf Teschke 
World J Hepatol 9(29):1141-1157. Published online Oct 18, 2017. doi: 10.4254/wjh.v9.i29.1141
49
Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis  
Daniela Campion, Ilaria Giovo, Paola Ponzo, Giorgio M Saracco, Federico Balzola, Carlo Alessandria 
World J Hepatol 11(6):489-512. Published online Jun 27, 2019. doi: 10.4254/wjh.v11.i6.489
50
Management of hepatitis B reactivation in immunosuppressed patients: An update on current recommendations  
Fernando Bessone, Melisa Dirchwolf 
World J Hepatol 8(8):385-394. Published online Mar 18, 2016. doi: 10.4254/wjh.v8.i8.385