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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis  
Linda Pasta, Francesca Pasta 
World J Hepatol 7(29):2920-2926. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2920
2
Focal liver lesions: Practical magnetic resonance imaging approach  
António P Matos, Fernanda Velloni, Miguel Ramalho, Mamdoh AlObaidy, Aruna Rajapaksha, Richard C Semelka 
World J Hepatol 7(16):1987-2008. Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.1987
3
Bacterial infections in cirrhosis: A critical review and practical guidance  
Chalermrat Bunchorntavakul, Naichaya Chamroonkul, Disaya Chavalitdhamrong 
World J Hepatol 8(6):307-321. Published online Feb 28, 2016. doi: 10.4254/wjh.v8.i6.307
4
Comprehensive review of post-liver resection surgical complications and a new universal classification and grading system  
Masayuki Ishii, Toru Mizuguchi, Kohei Harada, Shigenori Ota, Makoto Meguro, Tomomi Ueki, Toshihiko Nishidate, Kenji Okita, Koichi Hirata 
World J Hepatol 6(10):745-751. Published online Oct 27, 2014. doi: 10.4254/wjh.v6.i10.745
5
Hepatocellular carcinoma: Review of disease and tumor biomarkers  
Jin Un Kim, Mohamed I F Shariff, Mary M E Crossey, Maria Gomez-Romero, Elaine Holmes, I Jane Cox, Haddy K S Fye, Ramou Njie, Simon D Taylor-Robinson 
World J Hepatol 8(10):471-484. Published online Apr 8, 2016. doi: 10.4254/wjh.v8.i10.471
6
7
Wilson’s disease: A review of what we have learned  
Kryssia Isabel Rodriguez-Castro, Francisco Javier Hevia-Urrutia, Giacomo Carlo Sturniolo 
World J Hepatol 7(29):2859-2870. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2859
8
Portal hypertensive gastropathy: A systematic review of the pathophysiology, clinical presentation, natural history and therapy  
Mihajlo Gjeorgjievski, Mitchell S Cappell 
World J Hepatol 8(4):231-262. Published online Feb 8, 2016. doi: 10.4254/wjh.v8.i4.231
9
10
Alcoholic liver disease  
Radan Bruha, Karel Dvorak, Jaromir Petrtyl 
World J Hepatol 4(3):81-90. Published online Mar 27, 2012. doi: 10.4254/wjh.v4.i3.81
11
Cystic echinococcosis of the liver: A primer for hepatologists  
Francesca Rinaldi, Enrico Brunetti, Andreas Neumayr, Marcello Maestri, Samuel Goblirsch, Francesca Tamarozzi 
World J Hepatol 6(5):293-305. Published online May 27, 2014. doi: 10.4254/wjh.v6.i5.293
12
Concept of the pathogenesis and treatment of cholelithiasis  
Vasiliy Ivanovich Reshetnyak 
World J Hepatol 4(2):18-34. Published online Feb 27, 2012. doi: 10.4254/wjh.v4.i2.18
13
Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion  
Christopher Valerio, Eleni Theocharidou, Andrew Davenport, Banwari Agarwal 
World J Hepatol 8(7):345-354. Published online Mar 8, 2016. doi: 10.4254/wjh.v8.i7.345
14
Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience  
Matthew M Yeh, Raymond S Yeung, Smith Apisarnthanarax, Renuka Bhattacharya, Carlos Cuevas, William P Harris, Tony Lim Kiat Hon, Siddharth A Padia, James O Park, Kevin M Riggle, Sayed S Daoud 
World J Hepatol 7(11):1460-1483. Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1460
15
Non-alcoholic fatty liver disease: The diagnosis and management  
Shehab M Abd El-Kader, Eman M Salah El-Den Ashmawy 
World J Hepatol 7(6):846-858. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.846
16
Vitamin D deficiency in chronic liver disease  
Paula Iruzubieta, Álvaro Terán, Javier Crespo, Emilio Fábrega 
World J Hepatol 6(12):901-915. Published online Dec 27, 2014. doi: 10.4254/wjh.v6.i12.901
17
Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy  
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jonathan David Roth, Jacob Jelsing, Niels Vrang, Michael Feigh 
World J Hepatol 8(16):673-684. Published online Jun 8, 2016. doi: 10.4254/wjh.v8.i16.673
18
Hepatitis C virus genetic variability and evolution  
Natalia Echeverría, Gonzalo Moratorio, Juan Cristina, Pilar Moreno 
World J Hepatol 7(6):831-845. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.831
19
Cutaneous manifestations of hepatitis C in the era of new antiviral agents  
Simone Garcovich, Matteo Garcovich, Rodolfo Capizzi, Antonio Gasbarrini, Maria Assunta Zocco 
World J Hepatol 7(27):2740-2748. Published online Nov 28, 2015. doi: 10.4254/wjh.v7.i27.2740
20
Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside  
Bing Hu, Shuang-Shuang Wang, Qin Du 
World J Hepatol 7(9):1209-1232. Published online May 28, 2015. doi: 10.4254/wjh.v7.i9.1209
21
Immunotherapy for hepatocellular carcinoma: From basic research to clinical use  
Yu-Peng Hong, Zi-Duo Li, Pankaj Prasoon, Qi Zhang 
World J Hepatol 7(7):980-992. Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.980
22
Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments  
Xavier Adhoute, Guillaume Penaranda, Jean Luc Raoul, Patrice Le Treut, Emilie Bollon, Jean Hardwigsen, Paul Castellani, Hervé Perrier, Marc Bourlière 
World J Hepatol 8(17):703-715. Published online Jun 18, 2016. doi: 10.4254/wjh.v8.i17.703
23
Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease  
Mustafa Koplay, Mesut Sivri, Hasan Erdogan, Alaaddin Nayman 
World J Hepatol 7(5):769-776. Published online Apr 18, 2015. doi: 10.4254/wjh.v7.i5.769
24
25
Hepatitis C virus syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin’s lymphoma, and cancer  
Clodoveo Ferri, Marco Sebastiani, Dilia Giuggioli, Michele Colaci, Poupak Fallahi, Alessia Piluso, Alessandro Antonelli, Anna Linda Zignego 
World J Hepatol 7(3):327-343. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.327
26
Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma  
Shilu Mathew, Hany Abdel-Hafiz, Abbas Raza, Kaneez Fatima, Ishtiaq Qadri 
World J Hepatol 8(10):485-498. Published online Apr 8, 2016. doi: 10.4254/wjh.v8.i10.485
27
Chronic hepatitis C: This and the new era of treatment  
Gaetano Bertino, Annalisa Ardiri, Maria Proiti, Giuseppe Rigano, Evelise Frazzetto, Shirin Demma, Maria Irene Ruggeri, Laura Scuderi, Giulia Malaguarnera, Nicoletta Bertino, Venerando Rapisarda, Isidoro Di Carlo, Adriana Toro, Federico Salomone, Mariano Malaguarnera, Emanuele Bertino, Michele Malaguarnera 
World J Hepatol 8(2):92-106. Published online Jan 18, 2016. doi: 10.4254/wjh.v8.i2.92
28
Physiopathology of splanchnic vasodilation in portal hypertension  
María Martell, Mar Coll, Nahia Ezkurdia, Imma Raurell, Joan Genescà 
World J Hepatol 2(6):208-220. Published online Jun 27, 2010. doi: 10.4254/wjh.v2.i6.208
29
Guide for diagnosis and treatment of hepatocellular carcinoma  
Magdy Hamed Attwa, Shahira Aly El-Etreby 
World J Hepatol 7(12):1632-1651. Published online Jun 28, 2015. doi: 10.4254/wjh.v7.i12.1632
30
From portal to splanchnic venous thrombosis: What surgeons should bear in mind  
Quirino Lai, Gabriele Spoletini, Rafael S Pinheiro, Fabio Melandro, Nicola Guglielmo, Jan Lerut 
World J Hepatol 6(8):549-558. Published online Aug 27, 2014. doi: 10.4254/wjh.v6.i8.549
31
Advances in cirrhosis: Optimizing the management of hepatic encephalopathy  
Andy Liu, Ryan B Perumpail, Radhika Kumari, Zobair M Younossi, Robert J Wong, Aijaz Ahmed 
World J Hepatol 7(29):2871-2879. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2871
32
Management of hepatitis B reactivation in immunosuppressed patients: An update on current recommendations  
Fernando Bessone, Melisa Dirchwolf 
World J Hepatol 8(8):385-394. Published online Mar 18, 2016. doi: 10.4254/wjh.v8.i8.385
33
Staging of liver fibrosis or cirrhosis: The role of hepatic venous pressure gradient measurement  
Ki Tae Suk, Dong Joon Kim 
World J Hepatol 7(3):607-615. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.607
34
35
Management before hepatectomy for hepatocellular carcinoma with cirrhosis  
Hisashi Nakayama, Tadatoshi Takayama 
World J Hepatol 7(20):2292-2302. Published online Sep 18, 2015. doi: 10.4254/wjh.v7.i20.2292
36
Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis  
Licia Polimeni, Maria Del Ben, Francesco Baratta, Ludovica Perri, Fabiana Albanese, Daniele Pastori, Francesco Violi, Francesco Angelico 
World J Hepatol 7(10):1325-1336. Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1325
37
Recommendations for the use of chemoembolization in patients with hepatocellular carcinoma: Usefulness of scoring system?  
Xavier Adhoute, Guillaume Penaranda, Paul Castellani, Herve Perrier, Marc Bourliere 
World J Hepatol 7(3):521-531. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.521
38
Hepatitis C genotype 4: The past, present, and future  
Tawhida Y Abdel-Ghaffar, Mostafa M Sira, Suzan El Naghi 
World J Hepatol 7(28):2792-2810. Published online Dec 8, 2015. doi: 10.4254/wjh.v7.i28.2792
39
Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease  
Vanessa Souza-Mello 
World J Hepatol 7(8):1012-1019. Published online May 18, 2015. doi: 10.4254/wjh.v7.i8.1012
40
Search for a cure for chronic hepatitis B infection: How close are we?  
Wah Wah Phyo, Alex Yu Sen Soh, Seng Gee Lim, Guan Huei Lee 
World J Hepatol 7(9):1272-1281. Published online May 28, 2015. doi: 10.4254/wjh.v7.i9.1272
41
Cirrhotic ascites review: Pathophysiology, diagnosis and management  
Christopher M Moore, David H Van Thiel 
World J Hepatol 5(5):251-263. Published online May 27, 2013. doi: 10.4254/wjh.v5.i5.251
42
Current biomarkers for hepatocellular carcinoma: Surveillance, diagnosis and prediction of prognosis  
Kerstin Schütte, Christian Schulz, Alexander Link, Peter Malfertheiner 
World J Hepatol 7(2):139-149. Published online Feb 27, 2015. doi: 10.4254/wjh.v7.i2.139
43
Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?  
Andrea De Gasperi, Ernestina Mazza, Manlio Prosperi 
World J Hepatol 8(7):355-367. Published online Mar 8, 2016. doi: 10.4254/wjh.v8.i7.355
44
Cirrhosis and autoimmune liver disease: Current understanding  
Rodrigo Liberal, Charlotte R Grant 
World J Hepatol 8(28):1157-1168. Published online Oct 8, 2016. doi: 10.4254/wjh.v8.i28.1157
45
Review on immunosuppression in liver transplantation  
Maryam Moini, Michael L Schilsky, Eric M Tichy 
World J Hepatol 7(10):1355-1368. Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1355
46
47
Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy  
Mohamed L Salem, Ahmed El-Badawy 
World J Hepatol 7(23):2449-2458. Published online Oct 18, 2015. doi: 10.4254/wjh.v7.i23.2449
48
49
Human immunodeficiency virus infection and the liver  
Megan Crane, David Iser, Sharon R Lewin 
World J Hepatol 4(3):91-98. Published online Mar 27, 2012. doi: 10.4254/wjh.v4.i3.91
50