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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis  
Linda Pasta, Francesca Pasta
World J Hepatol 7(29):2920-2926. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2920
2
Comprehensive review of post-liver resection surgical complications and a new universal classification and grading system  
Masayuki Ishii, Toru Mizuguchi, Kohei Harada, Shigenori Ota, Makoto Meguro, Tomomi Ueki, Toshihiko Nishidate, Kenji Okita, Koichi Hirata
World J Hepatol 6(10):745-751. Published online Oct 27, 2014. doi: 10.4254/wjh.v6.i10.745
3
Bacterial infections in cirrhosis: A critical review and practical guidance  
Chalermrat Bunchorntavakul, Naichaya Chamroonkul, Disaya Chavalitdhamrong
World J Hepatol 8(6):307-321. Published online Feb 28, 2016. doi: 10.4254/wjh.v8.i6.307
4
Focal liver lesions: Practical magnetic resonance imaging approach  
António P Matos, Fernanda Velloni, Miguel Ramalho, Mamdoh AlObaidy, Aruna Rajapaksha, Richard C Semelka
World J Hepatol 7(16):1987-2008. Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.1987
5
Hepatocellular carcinoma: Review of disease and tumor biomarkers  
Jin Un Kim, Mohamed I F Shariff, Mary M E Crossey, Maria Gomez-Romero, Elaine Holmes, I Jane Cox, Haddy K S Fye, Ramou Njie, Simon D Taylor-Robinson
World J Hepatol 8(10):471-484. Published online Apr 8, 2016. doi: 10.4254/wjh.v8.i10.471
6
New advances in hepatocellular carcinoma  
Sonia Pascual, Iván Herrera, Javier Irurzun
World J Hepatol 8(9):421-438. Published online Mar 28, 2016. doi: 10.4254/wjh.v8.i9.421
7
Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma  
Shilu Mathew, Hany Abdel-Hafiz, Abbas Raza, Kaneez Fatima, Ishtiaq Qadri
World J Hepatol 8(10):485-498. Published online Apr 8, 2016. doi: 10.4254/wjh.v8.i10.485
8
Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion  
Christopher Valerio, Eleni Theocharidou, Andrew Davenport, Banwari Agarwal
World J Hepatol 8(7):345-354. Published online Mar 8, 2016. doi: 10.4254/wjh.v8.i7.345
9
Portal hypertensive gastropathy: A systematic review of the pathophysiology, clinical presentation, natural history and therapy  
Mihajlo Gjeorgjievski, Mitchell S Cappell
World J Hepatol 8(4):231-262. Published online Feb 8, 2016. doi: 10.4254/wjh.v8.i4.231
10
Hepatitis C virus: Virology, diagnosis and treatment  
Hui-Chun Li, Shih-Yen Lo
World J Hepatol 7(10):1377-1389. Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1377
11
Wilson’s disease: A review of what we have learned  
Kryssia Isabel Rodriguez-Castro, Francisco Javier Hevia-Urrutia, Giacomo Carlo Sturniolo
World J Hepatol 7(29):2859-2870. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2859
12
Cirrhosis and autoimmune liver disease: Current understanding  
Rodrigo Liberal, Charlotte R Grant
World J Hepatol 8(28):1157-1168. Published online Oct 8, 2016. doi: 10.4254/wjh.v8.i28.1157
13
Cutaneous manifestations of hepatitis C in the era of new antiviral agents  
Simone Garcovich, Matteo Garcovich, Rodolfo Capizzi, Antonio Gasbarrini, Maria Assunta Zocco
World J Hepatol 7(27):2740-2748. Published online Nov 28, 2015. doi: 10.4254/wjh.v7.i27.2740
14
Hepatitis C virus genetic variability and evolution  
Natalia Echeverría, Gonzalo Moratorio, Juan Cristina, Pilar Moreno
World J Hepatol 7(6):831-845. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.831
15
Alcoholic liver disease  
Radan Bruha, Karel Dvorak, Jaromir Petrtyl
World J Hepatol 4(3):81-90. Published online Mar 27, 2012. doi: 10.4254/wjh.v4.i3.81
16
Targeting the tumor stroma in hepatocellular carcinoma  
Femke Heindryckx, Pär Gerwins
World J Hepatol 7(2):165-176. Published online Feb 27, 2015. doi: 10.4254/wjh.v7.i2.165
17
Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments  
Xavier Adhoute, Guillaume Penaranda, Jean Luc Raoul, Patrice Le Treut, Emilie Bollon, Jean Hardwigsen, Paul Castellani, Hervé Perrier, Marc Bourlière
World J Hepatol 8(17):703-715. Published online Jun 18, 2016. doi: 10.4254/wjh.v8.i17.703
18
Current biomarkers for hepatocellular carcinoma: Surveillance, diagnosis and prediction of prognosis  
Kerstin Schütte, Christian Schulz, Alexander Link, Peter Malfertheiner
World J Hepatol 7(2):139-149. Published online Feb 27, 2015. doi: 10.4254/wjh.v7.i2.139
19
Therapeutic and clinical aspects of portal vein thrombosis in patients with cirrhosis  
Massimo Primignani, Giulia Tosetti, Vincenzo La Mura
World J Hepatol 7(29):2906-2912. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2906
20
Cystic echinococcosis of the liver: A primer for hepatologists  
Francesca Rinaldi, Enrico Brunetti, Andreas Neumayr, Marcello Maestri, Samuel Goblirsch, Francesca Tamarozzi
World J Hepatol 6(5):293-305. Published online May 27, 2014. doi: 10.4254/wjh.v6.i5.293
21
Effectiveness of hepatitis B virus vaccination program in Egypt: Multicenter national project  
Iman I Salama, Samia M Sami, Zeinab Nabil Ahmed Said, Manal H El-Sayed, Lobna A El Etreby, Thanaa M Rabah, Dalia M Elmosalami, Amany T Abdel Hamid, Somaia I Salama, Aida M Abdel Mohsen, Hanaa M Emam, Safaa M Elserougy, Amal I Hassanain, Naglaa F Abd Alhalim, Fatma A Shaaban, Samia A Hemeda, Nihad A Ibrahim, Ammal M Metwally
World J Hepatol 7(22):2418-2426. Published online Oct 8, 2015. doi: 10.4254/wjh.v7.i22.2418
22
Staging of liver fibrosis or cirrhosis: The role of hepatic venous pressure gradient measurement  
Ki Tae Suk, Dong Joon Kim
World J Hepatol 7(3):607-615. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.607
23
Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis  
Licia Polimeni, Maria Del Ben, Francesco Baratta, Ludovica Perri, Fabiana Albanese, Daniele Pastori, Francesco Violi, Francesco Angelico
World J Hepatol 7(10):1325-1336. Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1325
24
Immunotherapy for hepatocellular carcinoma: From basic research to clinical use  
Yu-Peng Hong, Zi-Duo Li, Pankaj Prasoon, Qi Zhang
World J Hepatol 7(7):980-992. Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.980
25
Advances in hepatitis C therapy: What is the current state - what come’s next?  
Steffen Zopf, Andreas E Kremer, Markus F Neurath, Juergen Siebler
World J Hepatol 8(3):139-147. Published online Jan 28, 2016. doi: 10.4254/wjh.v8.i3.139
26
Hepatitis B reactivation in the setting of chemotherapy and immunosuppression - prevention is better than cure  
Venessa Pattullo
World J Hepatol 7(7):954-967. Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.954
27
Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy  
Mohamed L Salem, Ahmed El-Badawy
World J Hepatol 7(23):2449-2458. Published online Oct 18, 2015. doi: 10.4254/wjh.v7.i23.2449
28
Vitamin D deficiency in chronic liver disease  
Paula Iruzubieta, Álvaro Terán, Javier Crespo, Emilio Fábrega
World J Hepatol 6(12):901-915. Published online Dec 27, 2014. doi: 10.4254/wjh.v6.i12.901
29
Cirrhotic ascites review: Pathophysiology, diagnosis and management  
Christopher M Moore, David H Van Thiel
World J Hepatol 5(5):251-263. Published online May 27, 2013. doi: 10.4254/wjh.v5.i5.251
30
Blood DNA methylation markers in prospectively identified hepatocellular carcinoma cases and controls from Taiwan  
Hui-Chen Wu, Jing Shen, Hwai-I Yang, Wei-Yann Tsai, Chien-Jen Chen, Regina M Santella
World J Hepatol 8(5):301-306. Published online Feb 18, 2016. doi: 10.4254/wjh.v8.i5.301
31
Non-alcoholic fatty liver disease in 2015  
Monjur Ahmed
World J Hepatol 7(11):1450-1459. Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1450
32
Guide for diagnosis and treatment of hepatocellular carcinoma  
Magdy Hamed Attwa, Shahira Aly El-Etreby
World J Hepatol 7(12):1632-1651. Published online Jun 28, 2015. doi: 10.4254/wjh.v7.i12.1632
33
Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience  
Matthew M Yeh, Raymond S Yeung, Smith Apisarnthanarax, Renuka Bhattacharya, Carlos Cuevas, William P Harris, Tony Lim Kiat Hon, Siddharth A Padia, James O Park, Kevin M Riggle, Sayed S Daoud
World J Hepatol 7(11):1460-1483. Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1460
34
Hepatitis D and hepatocellular carcinoma  
Zaigham Abbas, Minaam Abbas, Sarim Abbas, Lubna Shazi
World J Hepatol 7(5):777-786. Published online Apr 18, 2015. doi: 10.4254/wjh.v7.i5.777
35
Management of hepatitis B reactivation in immunosuppressed patients: An update on current recommendations  
Fernando Bessone, Melisa Dirchwolf
World J Hepatol 8(8):385-394. Published online Mar 18, 2016. doi: 10.4254/wjh.v8.i8.385
36
Management of patients with hepatitis C infection and renal disease  
Chalermrat Bunchorntavakul, Monthira Maneerattanaporn, Disaya Chavalitdhamrong
World J Hepatol 7(2):213-225. Published online Feb 27, 2015. doi: 10.4254/wjh.v7.i2.213
37
Advances in hepatocellular carcinoma: Nonalcoholic steatohepatitis-related hepatocellular carcinoma  
Fauzia Z Khan, Ryan B Perumpail, Robert J Wong, Aijaz Ahmed
World J Hepatol 7(18):2155-2161. Published online Aug 28, 2015. doi: 10.4254/wjh.v7.i18.2155
38
Controversies in the management of primary sclerosing cholangitis  
Jeremy S Nayagam, Stephen P Pereira, John Devlin, Phillip M Harrison, Deepak Joshi
World J Hepatol 8(5):265-272. Published online Feb 18, 2016. doi: 10.4254/wjh.v8.i5.265
39
Progress and prospects of engineered sequence-specific DNA modulating technologies for the management of liver diseases  
Samantha A Nicholson, Buhle Moyo, Patrick B Arbuthnot
World J Hepatol 7(6):859-873. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.859
40
Search for a cure for chronic hepatitis B infection: How close are we?  
Wah Wah Phyo, Alex Yu Sen Soh, Seng Gee Lim, Guan Huei Lee
World J Hepatol 7(9):1272-1281. Published online May 28, 2015. doi: 10.4254/wjh.v7.i9.1272
41
Management before hepatectomy for hepatocellular carcinoma with cirrhosis  
Hisashi Nakayama, Tadatoshi Takayama
World J Hepatol 7(20):2292-2302. Published online Sep 18, 2015. doi: 10.4254/wjh.v7.i20.2292
42
Recommendations for the use of chemoembolization in patients with hepatocellular carcinoma: Usefulness of scoring system?  
Xavier Adhoute, Guillaume Penaranda, Paul Castellani, Herve Perrier, Marc Bourliere
World J Hepatol 7(3):521-531. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.521
43
Clinical applications of squamous cell carcinoma antigen-immunoglobulins M to monitor chronic hepatitis C  
Andrea Martini, Andrea Gallotta, Patrizia Pontisso, Giorgio Fassina
World J Hepatol 7(29):2913-2919. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2913
44
Detection of hepatitis B virus infection: A systematic review  
Mallika Ghosh, Srijita Nandi, Shrinwanti Dutta, Malay Kumar Saha
World J Hepatol 7(23):2482-2491. Published online Oct 18, 2015. doi: 10.4254/wjh.v7.i23.2482
45
Management of non-alcoholic fatty liver disease in 2015  
Neel Malhotra, Melanie D Beaton
World J Hepatol 7(30):2962-2967. Published online Dec 28, 2015. doi: 10.4254/wjh.v7.i30.2962
46
Advances in cirrhosis: Optimizing the management of hepatic encephalopathy  
Andy Liu, Ryan B Perumpail, Radhika Kumari, Zobair M Younossi, Robert J Wong, Aijaz Ahmed
World J Hepatol 7(29):2871-2879. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2871
47
Hepatitis C genotype 4: The past, present, and future  
Tawhida Y Abdel-Ghaffar, Mostafa M Sira, Suzan El Naghi
World J Hepatol 7(28):2792-2810. Published online Dec 8, 2015. doi: 10.4254/wjh.v7.i28.2792
48
Bile acid receptors and nonalcoholic fatty liver disease  
Liyun Yuan, Kiran Bambha
World J Hepatol 7(28):2811-2818. Published online Dec 8, 2015. doi: 10.4254/wjh.v7.i28.2811
49
Concept of the pathogenesis and treatment of cholelithiasis  
Vasiliy Ivanovich Reshetnyak
World J Hepatol 4(2):18-34. Published online Feb 27, 2012. doi: 10.4254/wjh.v4.i2.18
50
Chronic hepatitis C: This and the new era of treatment  
Gaetano Bertino, Annalisa Ardiri, Maria Proiti, Giuseppe Rigano, Evelise Frazzetto, Shirin Demma, Maria Irene Ruggeri, Laura Scuderi, Giulia Malaguarnera, Nicoletta Bertino, Venerando Rapisarda, Isidoro Di Carlo, Adriana Toro, Federico Salomone, Mariano Malaguarnera, Emanuele Bertino, Michele Malaguarnera
World J Hepatol 8(2):92-106. Published online Jan 18, 2016. doi: 10.4254/wjh.v8.i2.92