Published online Mar 27, 2014. doi: 10.4254/wjh.v6.i3.144
Revised: January 27, 2014
Accepted: February 20, 2014
Published online: March 27, 2014
Core tip: One of the mechanisms of liver damage caused by alcohol is the generation of free radicals formed by the metabolism of this xenobiotic. Silymarin is an antioxidant that protects the liver from the free radical damage produced by alcohol metabolism. Silymarin is the most used natural compound for the treatment of hepatic diseases worldwide due to its antioxidant, anti-inflammatory, and anti-fibrotic activities. Silymarin functions by stabilizing biological membranes and increasing protein synthesis.