Published online Dec 27, 2014. doi: 10.4254/wjh.v6.i12.901
Revised: October 14, 2014
Accepted: November 7, 2014
Published online: December 27, 2014
Core tip: (Vitamin D and liver disease) vitamin D deficiency has been frequently reported in many causes of chronic liver disease and has been associated with the development and evolution of non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) virus infection. The role of vitamin D in the pathogenesis of NAFLD and CHC is not completely known, but it seems that the involvement of vitamin D in the activation and regulation of both innate and adaptive immune systems and its antiproliferative effect may explain its importance in these liver diseases.