Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jonathan David Roth, Jacob Jelsing, Niels Vrang, Michael Feigh
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jacob Jelsing, Niels Vrang, Michael Feigh, Gubra Aps, 2970 Hørsholm, Denmark
Jonathan David Roth, Intercept Pharmaceuticals, Inc., San Diego, CA 9212, United States
Author contributions: Kristiansen MNB, Veidal SS, Rigbolt KTG, Tølbøl KS and Feigh M performed the experiments and analyzed the data; Rigbolt KTG performed the molecular investigations; Kristiansen MNB and Veidal SS performed the histological analysis; Veidal SS, Rigbolt KTG, Roth JD, Jelsing J, Vrang N and Feigh M designed and coordinated the research; Kristiansen MNB, Veidal SS, Rigbolt KTG, Tølbøl KS, Roth JD, Jelsing J, Vrang N and Feigh M wrote the paper.
Institutional review board statement: This study includes no data or material from patients. We confirm that all of the required permissions for this study were obtained from our local authorities as mentioned in the Institutional animal care and use committee statement.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Danish Committee for animal research and covered by a personal license for Jacob Jelsing (2013-15-2934-00784). All of the institutional and national guidelines for the care and use of laboratory animals were followed.
Conflict-of-interest statement: There are no patents, products in development or marked products to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Michael Feigh, PhD, Gubra Aps, Hørsholm Kongevej 11B, 2970 Hørsholm, Denmark. mfe@gubra.dk
Telephone: +45-31522651
Received: February 11, 2016
Peer-review started: February 12, 2016
First decision: March 9, 2016
Revised: April 1, 2016
Accepted: April 20, 2016
Article in press: April 22, 2016
Published online: June 8, 2016
