Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.607
Peer-review started: August 28, 2014
First decision: November 3, 2014
Revised: December 11, 2014
Accepted: December 29, 2014
Article in press: December 29, 2014
Published online: March 27, 2015
Liver fibrosis is a common histological change of chronic liver injury and it is closely related with portal hypertension which is hemodynamic complication of chronic liver disease. Currently, liver fibrosis has been known as a reversible dynamic process in previous literatures. Although liver biopsy is a gold standard for assessing the stage of liver fibrosis, it may not completely represent the stage of liver fibrosis because of sampling error or semi-quantative measurement. Recent evidences suggested that histologic, clinical, hemodynamic, and biologic features are closely associated in patients with chronic liver disease. Hepatic venous pressure gradient (HVPG) measurement has been known as a modality to evaluate the portal pressure. The HVPG measurement has been used clinically for fibrosis diagnosis, risk stratification, preoperative screening for liver resection, monitoring the efficacy of medical treatments, and assessing the prognosis of liver fibrosis. Therefore, the HVPG measurement can be used to monitor areas the chronic liver disease but also other important areas of chronic liver disease.
Core tip: Hepatic venous pressure gradient (HVPG) measurement has been used in the clinical fields such as diagnosis of fibrosis, risk stratification, preoperative screening for liver resection, monitoring of the efficacy of medical treatment, and assessing the prognosis of liver fibrosis. HVPG measurement, along with monitoring stage the liver fibrosis, will play important roles in the field of chronic liver disease.